Results 101 to 110 of about 272,016 (336)

Avances de la AER General Pico 2023-2024

open access: yes
Esta publicación cuenta con trabajos desarrollados por los profesionales y personal de apoyo técnico de la Agencia de Extensión Rural de General Pico del INTA durante el período 2023 / 2024.
Ghironi, Eugenia Margarita (compiladora)   +1 more
core   +1 more source

A Novel Biostimulant for Enhancing Biomass and Therapeutic Compounds in Cannabis sativa

open access: yesInternational Journal of Plant Biology
Biostimulants represent a sustainable strategy to enhance the therapeutic potential of medicinal plants, which often exhibit low and variable levels of bioactive compounds.
Carlos Armas-Díaz   +11 more
doaj   +1 more source

Molecular Dynamics‐Guided Sterol Engineering of mRNA‐Lipid Nanoparticles Reprograms Biodistribution and Enhances Spleen‐Selective Immunity

open access: yesAdvanced Science, EarlyView.
Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon   +27 more
wiley   +1 more source

The promotion of primary education in the Provinces of Socorro and Pamplona, 1819-1825: Contributions to the founding process of the Republic [PDF]

open access: yes, 2015
Este artículo tiene por objeto analizar los adelantos y escollos afrontados en el proyecto de implementación de escuelas primarias de carácter público en las provincias de Socorro y Pamplona en los primeros años de vida republicana.
Pita Pico, Roger
core   +1 more source

High‐Density E. Coli Cultivation Arrays for Combinatorial Drug Testing With Subsequent Lipid Profiling by MALDI‐MS

open access: yesAdvanced Science, EarlyView.
High‐throughput antibiotic cross‐gradient assays on microdroplet arrays. A multichannel printhead together with five pressure regulators forms droplet arrays of up to 20 832 droplets within 25 minutes. Each droplet contains unique concentrations of antibiotics, allowing to moniture a vast spectrum of bacterial repsonses over night. The bacterial growth
M. Breitfeld   +5 more
wiley   +1 more source

Velocity Independent Constraints on Spin-Dependent DM-Nucleon Interactions from IceCube and PICO

open access: yes, 2020
Adopting the Standard Halo Model (SHM) of an isotropic Maxwellian velocity distribution for dark matter (DM) particles in the Galaxy, the most stringent current constraints on their spin-dependent scattering cross-section with nucleons come from the ...
IceCube Collaboration   +1 more
core   +1 more source

Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance

open access: yesAdvanced Science, EarlyView.
Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer   +9 more
wiley   +1 more source

La dimensión racial del capitalismo: Entrevista a Daniel Montañez Pico

open access: yes, 2021
Daniel Montañez Pico (Madrid, 1986) es profesor de la Universidad Nacional Autónoma de México y colabora habitualmente como articulista en Ojarasca, suplemento sobre asuntos indígenas de La Jornada.
López Arnal, Salvador   +1 more
core   +1 more source

Intratumoral Hypoxia Triggers Mitochondrial BHLHE40 ROS Sensing Pathway to Promote Radioresistance in Triple‐Negative Breast Cancer

open access: yesAdvanced Science, EarlyView.
Hypoxia triggers a dual mechanism for BHLHE40 upregulation: reactive oxygen species (ROS)‐dependent post‐translational modification and hypoxia‐inducible factor (HIF)‐dependent transcriptional activation. Under hypoxic conditions, mitochondrial BHLHE40 accumulates and senses ROS via cysteine thiol oxidation and disulfide‐linked homodimer formation ...
Jia Liu   +13 more
wiley   +1 more source

PICO to PICOS: Weak Supervision to Extend Datasets with New Labels

open access: yes
Hand-labelling clinical corpora can be costly and inflexible, requiring re-annotation every time new classes need to be extracted. PICO (Participant, Intervention, Comparator, Outcome) information extraction can expedite conducting systematic reviews to answer clinical questions. However, PICO frequently extends to other entities such as Study type and
Anjani Dhrangadhariya   +2 more
openaire   +2 more sources

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