Results 81 to 90 of about 207,364 (249)

The promotion of primary education in the Provinces of Socorro and Pamplona, 1819-1825: Contributions to the founding process of the Republic [PDF]

open access: yes, 2015
Este artículo tiene por objeto analizar los adelantos y escollos afrontados en el proyecto de implementación de escuelas primarias de carácter público en las provincias de Socorro y Pamplona en los primeros años de vida republicana.
Pita Pico, Roger
core   +1 more source

Membrane‐Active Peptide Protects Against Inflammation by Targeting NLRP3 Activation at the Trans‐Golgi Network

open access: yesAdvanced Science, EarlyView.
The membrane‐active peptide Pep19‐2.5 reduces harmful inflammation by blocking activation of the NLRP3 inflammasome at trans‐Golgi network membranes. By targeting key membrane interactions, Pep19‐2.5 suppresses inflammatory IL‐1β production and alleviates allergic airway inflammation in mice, leading to reduced immune cell infiltration and improved ...
Jonas Engelhardt   +16 more
wiley   +1 more source

Velocity Independent Constraints on Spin-Dependent DM-Nucleon Interactions from IceCube and PICO

open access: yes, 2020
Adopting the Standard Halo Model (SHM) of an isotropic Maxwellian velocity distribution for dark matter (DM) particles in the Galaxy, the most stringent current constraints on their spin-dependent scattering cross-section with nucleons come from the ...
IceCube Collaboration   +1 more
core   +1 more source

PolyG Fibrils Coalesce Into Nuclear Ribbons That Engage Proteostasis Machinery in Neuronal Intranuclear Inclusion Disease

open access: yesAdvanced Science, EarlyView.
In NIID, expanded NOTCH2NLC repeats give rise to nuclear polyG inclusions. Tracer‐guided in situ cryo‐electron tomography enables cross‐scale structural analysis from mouse brain to native neuronal nuclei, revealing dense‐core/peripheral‐halo inclusions built from compact polyG ribbons.
Hui Dong   +13 more
wiley   +1 more source

La dimensión racial del capitalismo: Entrevista a Daniel Montañez Pico

open access: yes, 2021
Daniel Montañez Pico (Madrid, 1986) es profesor de la Universidad Nacional Autónoma de México y colabora habitualmente como articulista en Ojarasca, suplemento sobre asuntos indígenas de La Jornada.
López Arnal, Salvador   +1 more
core   +1 more source

Molecular Dynamics‐Guided Sterol Engineering of mRNA‐Lipid Nanoparticles Reprograms Biodistribution and Enhances Spleen‐Selective Immunity

open access: yesAdvanced Science, EarlyView.
Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon   +27 more
wiley   +1 more source

High‐Density E. Coli Cultivation Arrays for Combinatorial Drug Testing With Subsequent Lipid Profiling by MALDI‐MS

open access: yesAdvanced Science, EarlyView.
High‐throughput antibiotic cross‐gradient assays on microdroplet arrays. A multichannel printhead together with five pressure regulators forms droplet arrays of up to 20 832 droplets within 25 minutes. Each droplet contains unique concentrations of antibiotics, allowing to moniture a vast spectrum of bacterial repsonses over night. The bacterial growth
M. Breitfeld   +5 more
wiley   +1 more source

Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance

open access: yesAdvanced Science, EarlyView.
Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer   +9 more
wiley   +1 more source

OV3DSeg-VGGT: Open-Vocabulary 3D Segmentation with Visual Geometry-Grounded Transformers

open access: yesVisual Informatics
Open-vocabulary 3D scene segmentation serves as a fundamental capability of human perception in computer vision, as it enables systems to recognize and segment arbitrary objects in complex environments.
Jingke Zhou   +7 more
doaj   +1 more source

Le medaglie dei Pico

open access: yes, 1994
Vengono descritte e inquadrate storicamente e criticamente nell'ambito della produzione medaglistica tra '400 e '600 le principali medaglie realizzate per i più illusti rappresentanti dei Pico, signori di Mirandola, attualmente conservate presso il ...
CORRADINI, Elena
core  

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