Results 121 to 130 of about 21,155 (219)

Picrosirius Red (PSR) Staining and Quantification in Mouse Ovaries v1

Picrosirius Red (PSR) staining is used to visualize collagen fibers in various tissues. When PSR binds to collagen fibers (specifically collagen I and III), it results in a dark red stain whereas the cytoplasmic regions appear yellow or faintly pink [1, 2].Generally, ovarian non-fibrotic regions stain darker pink than liver non-fibrotic regions ...
Francesca E. Duncan, Michele T Pritchard
openaire   +1 more source

Osteocyte dysfunction promotes osteoarthritis through MMP13-dependent suppression of subchondral bone homeostasis. [PDF]

, 2019
Osteoarthritis (OA), long considered a primary disorder of articular cartilage, is commonly associated with subchondral bone sclerosis. However, the cellular mechanisms responsible for changes to subchondral bone in OA, and the extent to which these ...
Acevedo, Claire, Alliston, Tamara, Bailey, Karsyn N, Dang, Alexis, Fields, Aaron J, Fowler, Tristan W, Kaya, Serra, Kuo, Alfred C, Lotz, Jeffrey C, Mazur, Courtney M, Vail, Thomas P, Woo, Jonathon J, Yee, Cristal S   +12 more
core  

Porphyromonas gingivalis GroEL exacerbates orthotopic allograft transplantation vasculopathy via impairment of endothelial cell function

Molecular Oral Microbiology, EarlyView.
Abstract Orthotopic allograft transplantation (OAT) is a significant approach to addressing organ failure. However, persistent immune responses to the allograft affect chronic rejection, which induces OAT vasculopathy (OATV) and organ failure. Porphyromonas gingivalis can infiltrate remote organs via the bloodstream, thereby intensifying the severity ...
Chien‐Sung Tsai, Chun‐Yao Huang, Yi‐Ting Tsai, Chun‐Ming Shih, Ze‐Hao Lai, Chen‐Wei Liu, Yi‐Wen Lin, Feng‐Yen Lin   +7 more
wiley   +1 more source

Porphyromonas gingivalis GroEL accelerates abdominal aortic aneurysm formation by matrix metalloproteinase‐2 SUMOylation in vascular smooth muscle cells: A novel finding for the activation of MMP‐2

Molecular Oral Microbiology, EarlyView.
Abstract Infection is a known cause of abdominal aortic aneurysm (AAA), and matrix metalloproteases‐2 (MMP‐2) secreted by vascular smooth muscle cells (SMCs) plays a key role in the structural disruption of the middle layer of the arteries during AAA progression.
Yi‐Wen Lin, Feng‐Yen Lin, Ze‐Hao Lai, Chien‐Sung Tsai, Yi‐Ting Tsai, Yen‐Sung Huang, Chen‐Wei Liu   +6 more
wiley   +1 more source

Collagen remodeling in equine exuberant granulation tissue characterized by Picrosirius Red staining

, 2023
Exuberant granulation tissue (EGT) is a disorder of second intention wound healing at distal limbs of horses. EGT is characterized by hyperproliferating granulation tissue. During the proliferative phase, myofibroblasts produce the immature collagen III which is later replaced by the mature collagen I in the remodeling phase.
Partusch, Lena, Michler, Jule Kristin, De Spiegelaere, Ward   +2 more
openaire   +1 more source

Photobiomodulation and platelet‐rich fibrin in the gastrocnemius muscle submitted to calcaneal tendinopathy in rats

Photochemistry and Photobiology, EarlyView.
The study evaluated different treatments for calcaneal tendinopathy in rats, focusing on the gastrocnemius muscle. Photobiomodulation (PBM), advanced platelet‐rich fibrin (A‐PRF), and their combination were tested. Treated animals showed improved muscle strength between 7 and 21 days, but without significant recovery of muscle fibers.
Pâmela Andressa Pauletto, Caroline Hammerschmitt Eduardo Schmitt, Fransael Franklyn Araújo da Silva, Maria Eduarda Luckner, Lucinéia de Fátima Chasko Ribeiro, Márcia Miranda Torrejais, Gladson Ricardo Flor Bertolini   +6 more
wiley   +1 more source

Picrosirius red staining for histology v1

Picrosirius red (PSR, aka Sirius red) staining is a histochemical technique for the identification of collagen and its specificity makes it suitable for robust quantitative assessments of collagen in tissue sections. Such digital image analysis is particularly valuable for the evaluation of fibrosis and tissue remodelling.
openaire   +1 more source

mTOR blockade prevents progressive proteinuria but induces hyperglycaemia in obese Dahl salt‐sensitive rats before puberty

Experimental Physiology, EarlyView.
Abstract Previous studies have demonstrated that mammalian target of rapamycin (mTOR) activity is significantly increased in the kidneys of Dahl salt‐sensitive (SS) rats during the development of renal injury. Therefore, in the present study we examined whether blockade of mTOR with rapamycin inhibits renal injury in Dahl salt‐sensitive leptin receptor
Sautan Mandal, Andrea K. Brown, Ubong S. Ekperikpe, Anukool A. Bhopatkar, Krystle M. Hughes, Tyler D. Johnson, Jonita S. Cooper, Konnor T. Wilbert, Denise C. Cornelius, Jan M. Williams   +9 more
wiley   +1 more source

Semaglutide impacts skeletal muscle to a similar extent as caloric restriction in mice with diet‐induced obesity

The Journal of Physiology, EarlyView.
Abstract figure legend Four weeks of semaglutide treatment causes significant reductions in total body weight, fat mass, lean mass, and grip strength in mice with diet induced obesity. Mice treated with semaglutide lost a greater amount of total body weight and fat mass compared to mice fed fed a calorie matched diet.
S. Jeromson, B. Baranowski, M. Akcan, B. D. Waters, K. Eisner, A. Bellucci, S. Trang, A. Abolhassani, M. A. Tello‐Palencia, A. Schweitzer, B. Stefanska, C. J. Mitchell, David C. Wright   +12 more
wiley   +1 more source

Identificação dos colágenos I, III, IV e α-SMA e participação dos miofibroblastos no processo fibrótico das endometroses equinas

Arquivo Brasileiro de Medicina Veterinária e Zootecnia
RESUMO A endometrose é uma alteração degenerativa das glândulas uterinas e do estroma circundante, caracterizada pelo arranjo periglandular de miofibroblastos e pela deposição de matriz extracelular (ECM).
L.D. Costa, M.C. Dias, M.A. Alvarenga, J.L. Sequeira   +3 more
doaj   +1 more source