Results 101 to 110 of about 16,762 (196)

Systemic pirfenidone treatment fails to mitigate fibrosis and compromises functional recovery in a porcine model of volumetric muscle loss

Experimental Physiology, EarlyView.
Abstract Repurposing clinically approved antifibrotic agents presents a potential near‐term therapeutic strategy to mitigate the extensive fibrotic scarring that follows severe volumetric muscle loss (VML) injury and inhibits functional recovery. We hypothesized that daily oral administration of pirfenidone, an FDA‐approved antifibrotic, would mitigate
Jessica M. Motherwell, Ondine Eken, Claudia E. Hernandez, Christopher L. Dearth, Stephen M. Goldman   +4 more
wiley   +1 more source

Semaglutide impacts skeletal muscle to a similar extent as caloric restriction in mice with diet‐induced obesity

The Journal of Physiology, EarlyView.
Abstract figure legend Four weeks of semaglutide treatment causes significant reductions in total body weight, fat mass, lean mass, and grip strength in mice with diet induced obesity. Mice treated with semaglutide lost a greater amount of total body weight and fat mass compared to mice fed fed a calorie matched diet.
S. Jeromson, B. Baranowski, M. Akcan, B. D. Waters, K. Eisner, A. Bellucci, S. Trang, A. Abolhassani, M. A. Tello‐Palencia, A. Schweitzer, B. Stefanska, C. J. Mitchell, David C. Wright   +12 more
wiley   +1 more source

Visualization of collagen fibers via picrosirius red staining and quantification of collagen content.

, 2016
Picrosirius red staining of (A) healthy and (B) diseased leaflets was visualized using brightfield microscopy and polarized light. Birefringence hue and amount were quantified as a percent of total tissue area (N = 5, n = 3) in the (C) fibrosa and (D ...
Kristyn S. Masters (154726), Taylor Marohl (3185436), Heather N. Hutson (3185433), Paul Campagnola (3185439), Kevin Eliceiri (3185430), Matthew Anderson (132634)   +5 more
core   +1 more source

Identificação dos colágenos I, III, IV e α-SMA e participação dos miofibroblastos no processo fibrótico das endometroses equinas

Arquivo Brasileiro de Medicina Veterinária e Zootecnia
RESUMO A endometrose é uma alteração degenerativa das glândulas uterinas e do estroma circundante, caracterizada pelo arranjo periglandular de miofibroblastos e pela deposição de matriz extracelular (ECM).
L.D. Costa, M.C. Dias, M.A. Alvarenga, J.L. Sequeira   +3 more
doaj   +1 more source

Caloric restriction and aerobic exercise differentially counteract muscle–tendon dysfunction following diet‐induced obesity in C57BL/6J mice

The Journal of Physiology, EarlyView.
Abstract figure legend Diet‐induced obesity induced fibro‐adipogenic remodelling of the muscle–tendon unit, characterized by increased fibrosis, reduced specific force, impaired relaxation kinetics, elevated hysteresis, and reduced aerobic capacity and glucose tolerance.
Leonardo Cesanelli, Petras Minderis, Andrej Fokin, Aivaras Ratkevicius, Ingrida Balnyte, Polzonetti Valeria, Tomas Venckunas, Cameron Hill, Danguole Satkunskiene, Hans Degens   +9 more
wiley   +1 more source

Correlations between MRI and all other readouts on day 23 analyzed in the present study for detection of bleomycin-induced lung fibrosis in BALB/c mice (n = 32; except for Picrosirius n = 16): total MRI signal volume, picrosirius staining, hydroxyproline, and gene expression of Col1α1, F4/80 and MMP12.

, 2013
Saline-treated BALB/c animals (n = 8, n = 4 for picrosirius) were used as controls.
Christelle Gérard (410767), Nicolau Beckmann (410774), Elizabeth Jarman (410768), Thomas Suply (187946), Christine Egger (410765), Gabor Jarai (410769), Arthur Micard (410771), Andrew Dunbar (410772), Catherine Cannet (410766), Bruno Tigani (410773), Agnès Feige (410770)   +10 more
core   +1 more source

Maternal protein restriction programs the ageing kidney: Proteomic signatures of early‐life origin renal and metabolic dysfunction

The Journal of Physiology, EarlyView.
Abstract figure legend Maternal protein restriction (MPR) induced persistent renal histopathological alterations accompanied by elevated serum creatinine levels. Nephron‐segment proteomic analysis revealed region‐specific molecular dysregulation affecting Bowman's capsule (PARK7, oxidative stress sensor; MSN, cytoskeletal organization), the proximal ...
Marina Pereira Pires, Matheus Naia Fioretto, Marcel Rodrigues Ferreira, Isabelle Tenori Ribeiro, Luísa Annibal Barata, Flávia Alessandra Maciel, Lucas Sobrinho Lemos, Renato Mattos, Luiz Marcos Frediane Portela, Patrick Vieira de Souza, Luisa Correia Gomes, Gustavo Monezzi Cordeiro, Wellerson Rodrigo Scarano, Patrícia Aline Boer, Jose Antonio Rocha Gontijo, Luis Antonio Justulin   +15 more
wiley   +1 more source

Morphology of wound healing on Day 22, showing similarity among experimental groups (hematoxilyn and eosin—A, C, E; Picrosirius Red—B D, F)

, 2015
Morphology of wound healing on Day 22, showing similarity among experimental groups (hematoxilyn and eosin—A, C, E; Picrosirius Red—B D, F)
Josiane Ferraretto Shibuya (729742), Brunna Pileggi de Azevedo Sampaio (729741), Amanda Pires Souza (729739), Cristiano de Loura Santana (729735), Daniela de Fátima Teixeira Silva (729736), Raquel Agnelli Mesquita-Ferrari (729744), Renato Araujo Prates (729738), Sandra Kalil Bussadori (729743), Kristianne Porta Santos Fernandes (729745), Cristiane Miranda França (729746), Alessandro Melo Deana (729737), Mariana Teixeira Gomes (729740)   +11 more
core   +1 more source

β‐Caryophyllene Mitigates Thioacetamide‐Induced Liver Fibrosis Through CB2‐Mediated Suppression of Necroptosis: A Therapeutic Investigation

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
β‐Caryophyllene is a multifunctional sesquiterpene with significant therapeutic potential. Our findings demonstrate that β‐caryophyllene exerts broad hepatoprotective effects through the activation of cannabinoid type 2 (CB2) receptors. These effects include suppression of oxidative stress–induced injury, attenuation of inflammatory responses ...
Lujain Bader Eddin, Seenipandi Arunachalam, Loay Lubbad, Fayez T. Hammad, Ernest Adeghate, Sandeep Subramanya, Shreesh Ojha   +6 more
wiley   +1 more source

A 3D‐Bioprinted, Cell‐Guiding Hydrogel Patch Promotes Functional Repair of Abdominal Incisions via Anisotropic ECM Remodeling

Smart Medicine, Volume 5, Issue 5, October 2026.
Abdominal incisions can heal into mechanically weak, disorganized scars. We developed a 3D‐bioprinted hydrogel patch with cell‐laden filaments oriented perpendicular to the incision, providing a guiding scaffold for local repair cells. This architecture supports organized collagen deposition and improves mechanical restoration of the healing abdominal ...
Tianxing Gong, Hao Li, Xueqiang Peng, Xinwei Liu, Xinyan Zhang, Qiushi Tang, Stephanie Willerth, Mario Taba Junior, Ricardo M. Carvalho, Hailong Yu, Shibo Wei, Hangyu Li   +11 more
wiley   +1 more source