Results 101 to 110 of about 13,582 (200)

Detrimental Effect of Low‐Magnitude High‐Frequency Vibration in an Ex Vivo Model of Intervertebral Disc Degeneration Despite Estrogen Treatment

JOR SPINE, Volume 9, Issue 2, June 2026.
Low‐magnitude high‐frequency vibration (LMHFV), with or without 17β‐oestradiol (E2), exacerbated papain‐induced bovine intervertebral disc degeneration, reducing cell viability, impairing matrix production, and increasing inflammation. E2 showed no protective effect against papain‐induced degeneration or LMHFV.
Jan Ulrich Jansen, Felizitas Figel, Franziska Widmayer, Morten Vogt, Maria Ahrens, Hans‐Joachim Wilke, Anita Ignatius, Melanie Haffner‐Luntzer, Cornelia Neidlinger‐Wilke, Graciosa Quelhas Teixeira   +9 more
wiley   +1 more source

Uso de quercetina a longo prazo em ratos cirróticos

Acta Cirúrgica Brasileira, 2003
OBJETIVO: Avaliar o uso a longo prazo do flavonóide quercetina em ratos cirróticos por ligadura de ducto biliar comum (LDB). MÉTODOS: Foram utilizados 32 ratos machos Wistar, sendo submetidos à LDB ou simulação, e distribuídos em 4 grupos: 1) controle, 2)
Miltersteiner Aline, Miltersteiner Diego, Pereira Filho Nelson, Frota Aline Rolim, Ely Pedro Bins, Zettler Cláudio Galeano, Marroni Cláudio Augusto, Marroni Norma P.   +7 more
doaj  

[Distribution of types I and III collagens in hepatic cirrhosis by the picrosirius polarization method].

Arquivos de gastroenterologia, 1985
The distribution of types I and III collagen fibrils was analysed in liver fragments of 18 cases of alcoholic hepatic cirrhosis. Using the method of picrosirius polarization the collagen fibrils type I and III were found to be very increased in both intra and extralobular connective tissue.
N H, Toppa, P, Raso
openaire   +1 more source

Picrosirius red, polarized light microscopy, and curvelet transform analysis: An improved method for liver fibrosis assessment

Tissue and Cell
Liver fibrosis is a hallmark of chronic liver diseases, characterized by excessive extracellular matrix deposition and structural alterations. Conventional histological assessments rely on qualitative or semi-quantitative scoring systems that may lack sensitivity for subtle fibrotic changes.
Carlos, Cuño-Gómiz, Anna, Tutusaus, Flavia, Savino, Patricia, Rider, Anna, Colell, Albert, Morales, Montserrat, Marí   +6 more
openaire   +2 more sources

Comparative Analysis of Dual‐miRNA Mediated Stimulation of Nucleus Pulposus and Bone Marrow Derived Stem Cells for Intervertebral Disc Repair

JOR SPINE, Volume 9, Issue 2, June 2026.
Nucleus pulposus (NP) and bone marrow derived stem cells (BMSCs) transfected with miRNA‐149‐5p‐mimic and 221‐3p‐inhibitor were evaluated in goat monolayer, microtissue, and ex vivo organ cultures of mild degeneration. miRNA‐treated NP cells demonstrated an anti‐catabolic and pro‐discogenic response in organs, highlighting its potential as a ...
Tara Ní Néill, Niamh Wilson, Jake McDonnell, Fergal J. O'Brien, Caroline M. Curtin, James E. Dixon, Pieter A. J. Brama, Conor T. Buckley   +7 more
wiley   +1 more source

Defining the Human Nucleus Pulposus Microenvironment and Its Impact on Cell Matrix Synthesis and Metabolic Activity

JOR SPINE, Volume 9, Issue 2, June 2026.
Human intervertebral disc nutrient microenvironment. Changes observed in microenvironmental profile as a result of degeneration outlined on upper vertebral body with ranges of each species as reported in previous studies. Oxygen, glucose, and lactate gradients are profiled across the lower disc in both healthy and degenerated states.
Niamh Wilson, Tara Ní Néill, Jake McDonnell, Emily McDonnell, Stacey Darwish, Joseph S. Butler, Conor T. Buckley   +6 more
wiley   +1 more source

Quantitative nanohistological investigation of scleroderma: an atomic force microscopy-based approach to disease characterization

International Journal of Nanomedicine, 2017
Adam P Strange,1 Sebastian Aguayo,1 Tarek Ahmed,1 Nicola Mordan,1 Richard Stratton,2 Stephen R Porter,3 Susan Parekh,4 Laurent Bozec1 1Department of Biomaterials and Tissue Engineering, UCL Eastman Dental Institute, 2Centre for Rheumatology and ...
Strange AP, Aguayo S, Ahmed T, Mordan N, Stratton R, Porter SR, Parekh S, Bozec L   +7 more
doaj  

Preclinical Efficacy and Safety Study of a Novel Dermal Fibroblast Modulating Drug, SLI‐F06, in Cutaneous Wound Healing

MedComm, Volume 7, Issue 6, June 2026.
A novel, chemically synthesized fibromodulin (FMOD)‐derived peptide, SLI‐F06, has been developed to significantly improve scar appearance, tensile strength, and histological outcomes among multiple preclinical animal models. Demonstrating no genotoxicity or systemic/local toxicity, SLI‐F06 has received United States Food and Drug Administration ...
Zhong Zheng, Pin Ha, Chenshuang Li, Grace Xinlian Chang, Wenlu Jiang, Xiaoxiao Pang, Zhaohan Zeng, Elisabeth Leeflang, Kang Ting, Chia Soo   +9 more
wiley   +1 more source

Structural Characterization of Cardiac Free‐Running Purkinje Fibers Using Inhomogeneous Magnetization Transfer (ihMT): A Proof of Concept MRI‐Histology Approach

NMR in Biomedicine, Volume 39, Issue 6, June 2026.
The cardiac Purkinje network is essential for synchronized ventricular activation but remains difficult to visualize with conventional MRI due to limited structural contrast. This study demonstrates that inhomogeneous magnetization transfer imaging provides enhanced contrast that differentiates free‐running Purkinje fibers, Purkinje‐Myocardial Junction,
Arash Forodighasemabadi, Evgenios N. Kornaropoulos, Marion Constantin, Lucas Soustelle, Fanny Vaillant, Jude Leury, Richard Walton, Olivier Bernus, Bruno Quesson, Olivier M. Girard, Guillaume Duhamel, Julie Magat   +11 more
wiley   +1 more source

Aspectos morfológicos da uretra de ratas após eletroestimulação do assoalho pélvico Morphological aspects of the urethra in female rats after electrical stimulation of the pelvic floor

Revista Brasileira de Ginecologia e Obstetrícia, 2013
OBJETIVO: Avaliar os efeitos da eletroestimulação (ES) do assoalho pélvico na uretra de ratas. MÉTODOS: Quarenta ratas adultas foram distribuídas, randomicamente, em quatro grupos com dez animais cada: Ctrl - sem intervenção; Sham - não foi submetido a ...
Adriana Luciana Moreno Camargo, Gisela Rosa Franco Salerno, Regina Célia Teixeira Gomes, Ricardo Santos Simões, Rodrigo de Aquino Castro, Manoel João Batista Castello Girão   +5 more
doaj