Results 111 to 120 of about 13,582 (200)

Mitochondrial Transplantation as a New Therapeutic Approach Against Cardiac and Renal Consequences in Male Rats With Myocardial Infarction

Acta Physiologica, Volume 242, Issue 6, June 2026.
ABSTRACT Aim Myocardial infarction (MI) is one of the leading causes of death worldwide. MI is associated with cardiac structural and functional alterations. Among these, cardiac fibrosis may be significantly influenced by mitochondrial dysfunction. We sought to evaluate whether the injection of functional mitochondria from healthy muscle could improve
María Cuesta‐Corral, Alejandro Montoro‐Garrido, Ana Romero‐Miranda, Fabián Islas, Bunty Ramchandani, Ricardo Gredilla, Joaquín Fernández‐Irigoyen, Enrique Santamaría, Beatriz Delgado‐Valero, Sara Jiménez‐González, Raquel Rodrigues Díez, María Luisa Nieto, Victoria Cachofeiro, Ernesto Martínez‐Martínez   +13 more
wiley   +1 more source

Ellagic Acid Attenuates Oxidative Stress and Improves Cardiovascular Function Following Myocardial Infarction in Ovariectomized Rats

Journal of Cellular and Molecular Medicine, Volume 30, Issue 12, June 2026.
ABSTRACT Oestrogen deficiency increases oxidative stress and reduces nitric oxide (NO) bioavailability, contributing to cardiac fibrosis following myocardial infarction (MI). This study investigated whether ellagic acid (EA), a natural antioxidant, attenuates post‐MI cardiac fibrosis in ovariectomized rats by reducing oxidative stress and pro ...
Laís Lopes Gonçalves, Ildernandes Vieira Alves, Erika Ferreira Nicoli, Deiviany Santana Santos Lima, Virginia Soares Lemos, A. Augusto Peluso, Patrick Wander Endlich, Simone Alves de Almeida, Glaucia Rodrigues de Abreu   +8 more
wiley   +1 more source

Effects of strain and age on ear wound healing and regeneration in mice

Brazilian Journal of Medical and Biological Research, 2009
Round holes in the ears of MRL mice tend to close with characteristics of regeneration believed to be absent in other mouse strains (e.g., C57BL/6). We evaluated the kinetics and the histopathology of ear wound closure in young (8 weeks old) C57BL/6 and ...
R.A. Costa, V. Ruiz-de-Souza, G.M. Azevedo Jr., N.M. Vaz, C.R. Carvalho   +4 more
doaj  

Empagliflozin and renal histological changes in an experimental model of heart failure in male rats

Physiological Reports, Volume 14, Issue 12, June 2026.
In a non‐diabetic rat model of heart failure, empagliflozin preserved renal structure by attenuating renal changes associated with congestion and tubular atrophy, while modulating inflammatory cell infiltration, characterized by increased CD206‐positive macrophages and reduced CD3‐positive T cells.
Aline Cavalcanti Toledo Wisnivesky, João Guilherme Ferreira Bertacchi, Bruno Caramelli   +2 more
wiley   +1 more source

Breaking the Heat Tolerance Response: The Crucial Role of MFAP4 in Combating Heat‐Induced Cardiac Injury

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
MFAP4 deficiency exacerbates heatstroke outcomes, accelerating hyperthermia, delaying recovery, reducing survival, and worsening cardiac injury. Conversely, MFAP4 overexpression enhances cellular thermoresistance. MFAP4 orchestrates transcriptional reprogramming in response to HS.
LiJun Fan, MingXiao Song, QingHan Zhang, ZiYi Guo, Jing Wang, XueWei Chen, ChenYi Hu, JunYu Lu, ZhuGe Xi   +8 more
wiley   +1 more source

Dual Knockout Models of the Spatially and Functionally Conserved rgra and rgrb Zebrafish Genes Reveal the Requirement of RGR for the Integrity of Cone‐Mediated Photopic Vision, the Photopic Visual Cycle and Bruch's Membrane Morphology

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
This study investigates the role of the vision gene RGR using novel dual knockout zebrafish models. The loss of rgra and rgrb results in zebrafish larvae having reduced visual function and altered retinoid profiles under light but not dark conditions. The OKR phenotype is enhanced under higher light intensities.
Grace Ruddin, Tess McCann, Joanna J. Kaylor, Michelle M. Fox, John D. Fehilly, Rebecca Ward, Adam Faulkner, Ailís L. Moran, Kieran Wynne, Roxana A. Radu, Michael G. Monaghan, Stephen D. Thorpe, Gabriel H. Travis, Breandán N. Kennedy   +13 more
wiley   +1 more source

TAK1 Regulates Skeletal Muscle Mass, Hypertrophic Signaling, and Metabolic Homeostasis in Male and Female Mice

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
Targeted inactivation of TAK1 induces more rapid muscle atrophy in male mice compared to female mice. In addition, loss of TAK1 impairs mechanical overload–induced phosphorylation of p70S6K and rpS6, leading to blunted muscle hypertrophic growth. TAK1 inactivation also promotes lipid accumulation while reducing fatty acid metabolism in skeletal muscle ...
Meiricris Tomaz da Silva, Aniket S. Joshi, Anirban Roy, Troy A. Hornberger, Ashok Kumar   +4 more
wiley   +1 more source

In Vitro Modulation of Murine Tenocyte Behavior by Hyperbaric Oxygen Therapy. [PDF]

J Orthop Res
Limberg AK, Giurleo LM, Ruiz V, Anup A, Buckey JC, Faro FD, Van Citters DW, Hixon KR.   +7 more
europepmc   +1 more source

Lung mTOR activation leads to lung fibrosis or emphysema via senescence of specific lung cells. [PDF]

Sci Rep
Houssaini A, Marcos E, Gros V, Born E, Abid S, Rideau D, Beaulieu D, Jacquet J, Lipskaia L, Gökyildirim M, Vienney N, Souktani R, Noureddine H, Boyer L, Bischof O, Derumeaux G, Adnot S, Jourdan Le Saux C.   +17 more
europepmc   +1 more source

Reducing Cartilage Warp in Nasal Reconstruction: The Role of Collagen and Proteoglycans. [PDF]

Plast Reconstr Surg Glob Open
Rafieian S, Whyne CM, Akens MK, Lam WW, Fialkov JA.   +4 more
europepmc   +1 more source