Results 121 to 130 of about 16,762 (196)

Uso de quercetina a longo prazo em ratos cirróticos

Acta Cirúrgica Brasileira, 2003
OBJETIVO: Avaliar o uso a longo prazo do flavonóide quercetina em ratos cirróticos por ligadura de ducto biliar comum (LDB). MÉTODOS: Foram utilizados 32 ratos machos Wistar, sendo submetidos à LDB ou simulação, e distribuídos em 4 grupos: 1) controle, 2)
Miltersteiner Aline, Miltersteiner Diego, Pereira Filho Nelson, Frota Aline Rolim, Ely Pedro Bins, Zettler Cláudio Galeano, Marroni Cláudio Augusto, Marroni Norma P.   +7 more
doaj  

Fermentation Time Modulates the Osteoprotective Effects of Milk Kefir in Glucocorticoid‐Induced Osteoporotic Rats

Molecular Nutrition &Food Research, Volume 70, Issue 17, 15 September 2026.
Milk kefir exerts osteoprotective effects in glucocorticoid‐induced osteoporotic rats, particularly when fermented for longer periods, improving mandibular bone quality. Fermentation time modulates its microbiological and bioactive profile, highlighting its potential as a functional food for restoring bone health.
Thays Allane Cordeiro Maia, Marco Gabriel Silva Leitão, Everton Cavalcante da Silva, Lorena Vasconcelos Vieira, Sofia Tavares Bessa, Igor Santos da Rocha, Paulo Goberlânio de Barros Silva, Francisca Andrea da Silva Oliveira, Paula Goes, Paola Gyuliane Gonçalves, Deborah Catharine de Assis Leite, Fabio Wildson Gurgel Costa, Lidiany Karla Azevedo Rodrigues, Delane Viana Gondim   +13 more
wiley   +1 more source

Lipodystrophy and adipose tissue recovery are mediated by the Wnt/lipogenesis axis during skin fibrosis

The Journal of Pathology, Volume 270, Issue 1, Page 98-113, September 2026.
Abstract Acquired lipodystrophy in the dermal white adipose tissue (DWAT) is an early phenotype of skin fibrosis, followed by the accumulation of extracellular matrix (ECM). Lipodystrophy syndromes are estimated to affect 1 in 20,000 people and are associated with metabolic comorbidities.
Suneeti R Madhavan, Piper Moore, Rohan Varshney, Miles Montegut, Qiannan Ma, Kayla Klatt, Reshmi Parameswaran, Elif G Ertugral, Chandrasekhar R Kothapalli, Michael C Rudolph, Radhika P Atit   +10 more
wiley   +1 more source

Quantitative nanohistological investigation of scleroderma: an atomic force microscopy-based approach to disease characterization

International Journal of Nanomedicine, 2017
Adam P Strange,1 Sebastian Aguayo,1 Tarek Ahmed,1 Nicola Mordan,1 Richard Stratton,2 Stephen R Porter,3 Susan Parekh,4 Laurent Bozec1 1Department of Biomaterials and Tissue Engineering, UCL Eastman Dental Institute, 2Centre for Rheumatology and ...
Strange AP, Aguayo S, Ahmed T, Mordan N, Stratton R, Porter SR, Parekh S, Bozec L   +7 more
doaj  

The Human PNPLA3I148M Polymorphism Alters the Renal Kinome and Transporters to Cause Hyperfiltration and Hypertension

FASEB BioAdvances, Volume 8, Issue 9, September 2026.
The present study used mice carrying the I148M polymorphism in the human Patatin‐like phospholipase domain‐containing protein 3 (PNPLA3I148M) to determine the role of this polymorphism in regulating blood pressure and renal filtration. Kinome analysis revealed that male PNPLA3I148M mice exhibited decreased phosphorylation of protein kinase c alpha ...
Gertrude Arthur, Michael I. Adenawoola, Sally Wahba, Bentley S. Montgomery, Claire B. Wingfield, Zachary A. Kipp, Terry D. Hinds Jr., David E. Stec   +7 more
wiley   +1 more source

Brazilian Green Propolis and Essential Oil Residues Improve Metabolic Dysfunction by Modulating Key Hepatic Lipogenic Genes in High‐Fat Diet‐Fed Mice

Journal of Food Science, Volume 91, Issue 9, September 2026.
ABSTRACT Obesity is closely associated with metabolic dysfunction, leading to impaired glucose and lipid homeostasis and contributing to the development of metabolic dysfunction–associated liver disease (MASLD). Propolis is a bee‐derived natural product rich in bioactive compounds and widely recognized for its antioxidant, anti‐inflammatory, and ...
Caroline Alves de Araújo, Giovana Dias Ramundo, Beatriz Teixeira dos Santos, Dafne Lopes Beserra Silva, Graziele Freitas de Bem, Dayane Teixeira Ognibene, Angela Castro Resende, Brenda Akemi Nagagata, Isabela Macedo Lopes Vasques‐Monteiro, Julio Beltrame Daleprane, Debora Baptista Pereira, Douglas Siqueira de Almeida Chaves, Cristiane Aguiar da Costa   +12 more
wiley   +1 more source

Insights Into the Interplay Between the Senescent Cells and Immune Cells

Aging Cell, Volume 25, Issue 9, September 2026.
Kidney aging is associated with increased proximal tubular senescence and leukocyte infiltration. Senolytic treatment reduces senescent cell burden and overall immune cell infiltration. However, macrophages remain enriched around residual senescent cells.
Martin Jaros, Marco Schmidt, Lavinia Neubert, Jan‐Christopher Kamp, Sibylle von Vietinghoff, Jan Hinrich Bräsen, Roland Schmitt, Anette Melk   +7 more
wiley   +1 more source

Aspectos morfológicos da uretra de ratas após eletroestimulação do assoalho pélvico Morphological aspects of the urethra in female rats after electrical stimulation of the pelvic floor

Revista Brasileira de Ginecologia e Obstetrícia, 2013
OBJETIVO: Avaliar os efeitos da eletroestimulação (ES) do assoalho pélvico na uretra de ratas. MÉTODOS: Quarenta ratas adultas foram distribuídas, randomicamente, em quatro grupos com dez animais cada: Ctrl - sem intervenção; Sham - não foi submetido a ...
Adriana Luciana Moreno Camargo, Gisela Rosa Franco Salerno, Regina Célia Teixeira Gomes, Ricardo Santos Simões, Rodrigo de Aquino Castro, Manoel João Batista Castello Girão   +5 more
doaj  

Mitochondrial Haplotype Shapes the Trajectory of Ovarian Aging in Genetically Heterogeneous Rats

Aging Cell, Volume 25, Issue 9, September 2026.
Using genetically heterogeneous rats carrying divergent mitochondrial haplotypes on a randomized nuclear background, we show that mtDNA variation modifies the rate of ovarian aging. OKC‐HETW ovaries showed bioenergetic deficits, reduced mtDNA copy number, and impaired TFAM–mtDNA binding by 4 months of age, with early fibrosis and immune infiltration ...
Subhasri Biswas, Hoang V. M. Nguyen, Aubrey Converse, Satoshi Matsuzaki, Michael T. Kinter, Kenneth M. Humphries, Willard M. Freeman, Sarah R. Ocañas, Arlan Richardson, Francesca E. Duncan, Tommy L. Lewis Jr, Michael B. Stout   +11 more
wiley   +1 more source

Pharmacological activation of NO‐cGMP signalling attenuates metabolic dysfunction‐associated steatohepatitis

British Journal of Pharmacology, Volume 183, Issue 18, Page 5476-5495, September 2026.
Background and Purpose Metabolic dysfunction‐associated steatohepatitis (MASH) is linked to activation of hepatic stellate cells (HSCs) to α‐smooth muscle actin–positive myofibroblasts that produce collagen and proinflammatory cytokines. Quiescent HSCs express the NO‐cGMP signalling axis.
Krithika Rajeeth, Malte Roessing, Moritz Lehners, Lisa Dietz, Anja Schmitt, Stephan Hailfinger, Andreas Peter, Leticia Quintanilla‐Martinez, Irene Gonzalez‐Menendez, Ingmar Mederacke, German Ott, Peter Sandner, Matthias Schwab, Robert Feil, Susanne Feil   +14 more
wiley   +1 more source