Results 131 to 140 of about 21,155 (219)

AI‐assisted design of a VEGFR2 agonistic peptide that promotes angiogenesis and wound repair

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Vascular endothelial growth factor (VEGF) serves as a principal regulator of neovascularization and is essential for vascular regeneration. In this study, we identified and evaluated VEGF Mimetic Peptide3 (VMP3), a novel synthetic peptide developed as a potential VEGFR‐2/VEGF‐A modulator.
Farzana Yasmeen, Rajath Ramachandran, Rameez Hassan Pirzada, Bogeum Choi, Hana Seo, Wook Kim, Moon Suk Kim, Sangdun Choi   +7 more
wiley   +1 more source

The anti‐fibrotic effects of novel heart failure pharmacotherapies in advanced heart failure patients

British Journal of Pharmacology, Volume 183, Issue 7, Page 1502-1516, April 2026.
Background and Purpose Novel heart failure (HF) pharmacotherapies, including angiotensin receptor‐neprilysin inhibitor (ARNI) and sodium‐glucose cotransporter 2 inhibitors (SGLT2is), may confer cardiovascular benefits by attenuating myocardial fibrosis. However, direct evidence from human failing myocardial samples is limited.
Dávid Nagy, Tamás Radovits, Tímea Bálint, Zoltán Horváth, Petra Kocsis‐Balogh, Ákos Gergely Tóth, Attila Oláh, Alex Ali Sayour, Bálint András Barta, Béla Merkely, Mihály Ruppert   +10 more
wiley   +1 more source

Tipos de colágeno na fibrose hepática esquistossomótica de Symmers

Revista da Sociedade Brasileira de Medicina Tropical, 1983
Os AA. estudaram o tipo de colágeno em cortes histológicos de fragmentos de fígado de 12 indivíduos portadores da forma hepatesplênica da esquistossomose mansoni, pela técnica de coloração pelo Sirius Supra Red F3BA.
Pedro Raso, Nivaldo Hartung Toppa, Dionne M. Oliveira, Francira P. Lemos   +3 more
doaj  

Evaluation of tissue response of experimental calcium silicate‐based endodontic sealers: An in vivo study

European Journal of Oral Sciences, Volume 134, Issue 2, April 2026.
Abstract The aim of this study was to evaluate whether the experimental sealers, composed of tricalcium silicate (CaSi) and CaSi supplemented with calcium hypochlorite (CaSi‐H), stimulate tissue repair. The tissue response of experimental materials was compared with commercially available materials Bio‐C sealer (BC sealer) and BioRoot (BROOT ...
Evelin Carine Alves Silva, Lucas de Andrade Rodrigues, Estela Sasso‐Cerri, Mário Tanomaru‐Filho, Juliane Maria Guerreiro‐Tanomaru, Paulo Sérgio Cerri   +5 more
wiley   +1 more source

Macro-based collagen quantification and segmentation in picrosirius red-stained heart sections using light microscopy

Biology Methods and Protocols
Abstract Picrosirius red staining constitutes an important and broadly used tool to visualize collagen and fibrosis in various tissues. Although multiple qualitative and quantitative analysis methods to evaluate fibrosis are available, many require specialized devices and software or lack objectivity and scalability.
Julian Kammerer, Alexandra Cirnu, Tatjana Williams, Melanie Hasselmeier, Mike Nörpel, Ruping Chen, Brenda Gerull   +6 more
openaire   +3 more sources

Achilles tenocytes from diabetic and non diabetic donors exposed to hyperglycemia respond differentially to inflammatory stimuli and stretch

Journal of Anatomy, Volume 248, Issue 4, Page 675-688, April 2026.
Scheme depicting the experimental set up of the study. Achilles tendons and tenocytes were isolated from heterozygous (fa/+, non diabetic: non DMT2) and homozygous (fa/fa, diabetic: DMT2) Zucker Diabetic Fatty (ZDF) rats. Tendon degeneration, collagen type 1 alpha 1 chain (COL1A1) and alpha smooth muscle actin (αSMA) expression was determined in rat ...
Nils Fleischmann, Sarah Hofmann, Clemens Gögele, Eva Frank, Christian Werner, Maria Kokozidou, Bernd Hoffmann, Jens Konrad, Gundula Schulze‐Tanzil   +8 more
wiley   +1 more source

Ultrastructural Islet Study of Early Fibrosis in the Ren2 Rat Model of Hypertension Emerging Role of the Islet Pancreatic Pericyte-Stellate Cell [PDF]

, 2007
Type 2 diabetes mellitus is a multifactorial disease with polygenic and environmental stressors resulting in multiple metabolic toxicities and islet oxidative stress.
Habibi, Javad, 1947-, Hayden, Melvin, Karuparthi, Poorna R., Lastra, Guido, Manrique, Camilla, Sowers, James R. (James Russell), 1942-, Stas, Sameer, Wasekar, Chetan   +7 more
core  

Uso de quercetina a longo prazo em ratos cirróticos

Acta Cirúrgica Brasileira, 2003
OBJETIVO: Avaliar o uso a longo prazo do flavonóide quercetina em ratos cirróticos por ligadura de ducto biliar comum (LDB). MÉTODOS: Foram utilizados 32 ratos machos Wistar, sendo submetidos à LDB ou simulação, e distribuídos em 4 grupos: 1) controle, 2)
Miltersteiner Aline, Miltersteiner Diego, Pereira Filho Nelson, Frota Aline Rolim, Ely Pedro Bins, Zettler Cláudio Galeano, Marroni Cláudio Augusto, Marroni Norma P.   +7 more
doaj  

Quantification of collagen fibers in canine uteri treated with medroxyprogesterone acetate

Pesquisa Veterinária Brasileira
: Collagen plays essential roles in remodeling uterine tissue during decidualization, implantation, pregnancy and involution. To understand whether the progestational agent medroxyprogesterone acetate (MPA) can modify the organization and deposit of ...
Paulo Salinas, Maria A. Miglino, Mariano del Sol   +2 more
doaj   +1 more source

Quantitative nanohistological investigation of scleroderma: an atomic force microscopy-based approach to disease characterization

International Journal of Nanomedicine, 2017
Adam P Strange,1 Sebastian Aguayo,1 Tarek Ahmed,1 Nicola Mordan,1 Richard Stratton,2 Stephen R Porter,3 Susan Parekh,4 Laurent Bozec1 1Department of Biomaterials and Tissue Engineering, UCL Eastman Dental Institute, 2Centre for Rheumatology and ...
Strange AP, Aguayo S, Ahmed T, Mordan N, Stratton R, Porter SR, Parekh S, Bozec L   +7 more
doaj