Results 71 to 80 of about 21,155 (219)

TRPC6 counteracts TRPC3-Nox2 protein complex leading to attenuation of hyperglycemia-induced heart failure in mice [PDF]

, 2017
Excess production of reactive oxygen species (ROS) caused by hyperglycemia is a major risk factor for heart failure. We previously reported that transient receptor potential canonical 3 (TRPC3) channel mediates pressure overload-induced maladaptive ...
Birnbaumer, Lutz, Harada, Eri, Ishikawa, Tatsuya, Kitajima, Naoyuki, Kumagai, Yoshito, Nishida, Motohiro, Nishimura, Akiyuki, Numaga Tomita, Takuro, Oda, Sayaka, Shimauchi, Tsukasa, Tomizaki, Takashi   +10 more
core   +1 more source

Characterization of the extracellular matrix from human and dog umbilical cords

The Anatomical Record, EarlyView.
Abstract The extracellular matrix is important for maintaining tissue morphogenesis and homeostasis; it can also be used as a biomaterial for the production of biological scaffolds. Particularly, the umbilical cord has shown potential in the production of scaffolds for small‐diameter vessels.
Ana Carla Mendonça, Roberta Losi Guembarovski, Carlos Alberto Miqueloto, Alda Fiorina Maria Losi Guembarovski, Caio Garcia Barbosa da Silva, Laís Capelasso Lucas Pinheiro, Phelipe Oliveira Favaron   +6 more
wiley   +1 more source

A dual flow bioreactor with controlled mechanical stimulation for cartilage tissue engineering [PDF]

, 2013
In cartilage tissue engineering bioreactors can create a controlled environment to study chondrocyte behavior under mechanical stimulation or produce chondrogenic grafts of clinically relevant size.
Apeldoorn, A.A. van, Blitterswijk, C.A. van, Costa, I.B.F., Deus, F.D., Karperien, H.B.J., Leijten, J.C.H., Spitters, T.W.G.M.   +6 more
core   +4 more sources

Dual Action of Dipyridamole in Experimental Rheumatoid Arthritis: Suppression of Joint Inflammation and Upregulation of Muscle Anabolism via Adenosine and AMPK pathways

Arthritis &Rheumatology, Accepted Article.
Introduction Rheumatoid sarcopenia, characterized by the progressive loss of skeletal muscle mass and function, is a frequent comorbidity in rheumatoid arthritis (RA), linked to prolonged, severe systemic inflammation. Purinergic signaling (adenosine, AMP, and ATP) plays a crucial role in inflammation, myogenesis, and muscle hypertrophy.
Miguel Marco‐Bonilla, Maria Fresnadillo, Irene Sanchez‐Platero, Macarena de la Riva‐Bueno, Fernando Huete‐Toral, Gonzalo Carracedo, Carmen Conde, Yolanda Benitez, Pablo Minguez, Sandra Carolina Cifuentes, Joaquin Rams, Gabriel Herrero‐Beaumont, Raquel Largo, Aránzazu Mediero   +13 more
wiley   +1 more source

Regurgitation Hemodynamics Alone Cause Mitral Valve Remodeling Characteristic of Clinical Disease States In Vitro [PDF]

, 2015
Mitral valve regurgitation is a challenging clinical condition that is frequent, highly varied, and poorly understood. While the causes of mitral regurgitation are multifactorial, how the hemodynamics of regurgitation impact valve tissue remodeling is an
Azimuddin, Anam F., Connell, Patrick S., Grande-Allen, K. Jane, Jackson, Matthew S., Kim, Seulgi E., Little, Stephen H., Ramirez, Fernando   +6 more
core   +1 more source

Osteogenic preconditioning in perfusion bioreactors improves vascularization and bone formation by human bone marrow aspirates. [PDF]

, 2020
Cell-derived extracellular matrix (ECM) provides a niche to promote osteogenic differentiation, cell adhesion, survival, and trophic factor secretion.
Genetos, DC, Gonzalez-Fernandez, T, Harvestine, JN, Hum, NR, Leach, JK, Loots, GG, Sebastian, A   +6 more
core  

Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction [PDF]

, 2014
Matrix metalloproteinase-9 (MMP-9) is prominently overexpressed after myocardial infarction (MI). We tested the hypothesis that mice with targeted deletion of MMP9 have less left ventricular (LV) dilation after experimental MI than do sibling wild-type ...
Aikawa, Masanori, Ducharme, Anique, Frantz, Stefan, Kelly, Ralph A., Lee, Richard Theodore, Libby, Peter, Lindsey, Merry, Rabkin, Elena, Rohde, Luis E., Schoen, Frederick Jack, Werb, Zena   +10 more
core   +1 more source

Anti‐atherosclerotic effect of the angiotensin 1–7 mimetic AVE0991 is mediated by inhibition of perivascular and plaque inflammation in early atherosclerosis [PDF]

, 2017
Background and Purpose: Inflammation plays a key role in atherosclerosis. A protective role of angiotensin-(1-7) in vascular pathologies opened a possibility for therapeutic use of small molecule non-peptide Ang-(1-7) mimetics, such as AVE0991.
Czesnikiewicz-Guzik, M., Guzik, T.J., Jawien, J., Korbut, R., Mikolajczyk, T.P., Montezano, A.C., Nosalski, R., Olszanecki, R., Rios, F.J., Siedlinski, M., Skiba, D.S., Touyz, R.M.   +11 more
core   +2 more sources

Non‐Nutritive Artificial Sweeteners Aspartame and Acesulfame‐K Ameliorate Metabolic Dysfunction‐Associated Steatotic Liver Disease in Male Ldlr−/− Mice

iNew Medicine, EarlyView.
ABSTRACT Aspartame and acesulfame‐K are commonly used non‐nutritive artificial sweeteners, but their impacts on cardiovascular disease and metabolic dysfunction‐associated fatty liver disease (MASLD) are unclear. In this study, we evaluated the impacts of aspartame and acesulfame‐K on MASLD and atherosclerosis in male Ldlr−/− mice fed an AMLN diet ...
Jingjing Xu, Xiaohua Jiang, Jianping Weng, Suowen Xu   +3 more
wiley   +1 more source

Collagenase treatment appears to improve cartilage tissue integration but damage to collagen networks is likely permanent

Journal of Tissue Engineering, 2022
When repairing cartilage defects a major challenge is achieving high-quality integration between the repair tissue and adjacent native cartilage. Matrix-rich cartilage is not easily remodeled, motivating several studies to trial enzyme treatment of the ...
Md. Shafiullah Shajib, Kathryn Futrega, Travis Jacob Klein, Ross W Crawford, Michael Robert Doran   +4 more
doaj   +1 more source