Results 91 to 100 of about 11,131 (244)

PIEZO1 promotes psoriasis-like skin inflammation in mice via NF-κB/IL-17 signaling pathway activation

Molecular Medicine
Background Psoriasis is a chronic inflammatory skin disorder characterized by hyperproliferative keratinocytes and an altered immune response. PIEZO1, a mechanically activated ion channel, has been implicated in various cellular processes, but its role ...
Wen Li, Kan Ze, Xufeng He, Lili Yang, Huimin Zhang, Weian Yuan, Wuqing Wang   +6 more
doaj   +1 more source

Piezo1 senses hyphae and initiates host defense against pathogenic fungi

Cell Reports
Summary: Candida albicans metamorphoses from benign yeast to a rigid hyphal, becoming an opportunistic pathogen in immunocompromised patients. The process by which immune cells discern fungal transformations remains elusive.
Yiran Shi, Bingying Yang, Yueyue Linghu, Yue Liu, Haoran Li, Yunzhi Xing, Binbin Wu, Yuting Gao, Liuqi Liao, Yi Zheng, Lei Pan, Xiufeng Sun, Qinghua Chen, Yongqiang Hou, Dongxue Su, Hongling Huang, Jiahuai Han, Shih-Chin Cheng, Dawang Zhou, Lanfen Chen   +19 more
doaj   +1 more source

Pressure-dependent regulation of Ca2+ signaling in the vascular endothelium [PDF]

, 2015
The endothelium is an interconnected network upon which hemodynamic mechanical forces act to control vascular tone and remodeling in disease. Ca2+ signaling is central to the endothelium's mechanotransduction and networked activity.
Girkin, John M., McCarron, John G., Saunter, Christopher D., Wilson, Calum   +3 more
core   +1 more source

A critical reappraisal of the carotid sinus and carotid bulb: Distinguishing neurohistological function from vascular geometry

The Anatomical Record, EarlyView.
This review redefines the carotid bulb (CB) as a variable geometric dilation shaped by hemodynamics and the carotid sinus (CS) as a conserved neurohistological baroreceptor field. Distinguishing these entities clarifies a century of anatomical confusion and links geometry, neurohistology, and clinical interpretation within a unified framework ...
Răzvan Costin Tudose, Nicolae Radu, Mugurel Constantin Rusu   +2 more
wiley   +1 more source

Sodium Channels and Mammalian Sensory Mechanotransduction [PDF]

, 2012
Background: Members of the degenerin/epithelial (DEG/ENaC) sodium channel family are mechanosensors in C elegans, and Nav1.7 and Nav1.8 voltage-gated sodium channel knockout mice have major deficits in mechanosensation.
Edith Hummler, Fan Wang, Francois Rugiero, Hannes Kiesewetter, John N Wood, Mohammed A Nassar, Rachel Hatch, Ramin Raouf   +7 more
core   +4 more sources

Microtopography enhances intestinal drug absorption via Piezo1‐mediated tight junction modulation

BMEMat, EarlyView.
Microtopography‐driven enhancement of oral peptide drug delivery by activating Piezo1 channels significantly improves paracellular permeability and bioavailability, offering a novel approach for optimizing macromolecule absorption in pharmaceutical formulations.
Yu Hu, Nan Xu, Xin Li, Xiaowo Kang, Tieyuan Bian, Junsheng Lin, Hao Tang, Yinyin Bao, Lu Zhang, Hongyan Yuan, Mingxi Yao, Xingyu Jiang, Zhi Luo   +12 more
wiley   +1 more source

Cardiomyocyte-specific Piezo1 deficiency mitigates ischemia-reperfusion injury by preserving mitochondrial homeostasis

Redox Biology
Ca2+ overload and mitochondrial dysfunction play crucial roles in myocardial ischemia-reperfusion (I/R) injury. Piezo1, a mechanosensitive cation channel, is essential for intracellular Ca2+ homeostasis.
Honglin Xu, Xin Chen, Shangfei Luo, Jintao Jiang, Xianmei Pan, Yu He, Bo Deng, Silin Liu, Rentao Wan, Liwen Lin, Qiaorui Tan, Xiaoting Chen, Youfen Yao, Bin He, Yajuan An, Jing Li   +15 more
doaj   +1 more source

Biophysical Regulation of Chromatin Architecture Instills a Mechanical Memory in Mesenchymal Stem Cells [PDF]

, 2015
This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the ...
Driscoll, TP, Duncan, RL, Heo, S-J, Lee, DA, Mauck, RL, Thorpe, SD   +5 more
core   +1 more source

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

Erythrocyte's aging in microgravity highlights how environmental stimuli shape metabolism and morphology [PDF]

, 2018
The determination of the function of cells in zero-gravity conditions is a subject of interest in many different research fields. Due to their metabolic unicity, the characterization of the behaviour of erythrocytes maintained in prolonged microgravity ...
Bellelli, Andrea, Boumis, Giovanna, Dietler, G, Dinarelli, Simone, Francioso, Antonio, Longo, Giovanni, Marco, Girasole, Mosca, Luciana, Pannitteri, G.   +8 more
core   +1 more source