Results 71 to 80 of about 10,071 (256)

The role of Piezo1 in immune cells and pregnancy

Frontiers in Immunology
In innate immunity, Piezo1 influences macrophage polarization, neutrophil migration, inflammation and repair. In adaptive immunity, it modulates T cell mechanosensation, immune synapse formation and B cell antigen presentation. Expressed in endometrium, placental vasculature, placental trophoblast and myometrium, Piezo1 regulates ...
Fei, Yiming, Liu, Yilin, Zhang, Lijuan
openaire   +2 more sources

Electronic Chip‐Mimetic Medical Implants for Controllable Sonothermal Treatments

Advanced Science, EarlyView.
Inspired by the thermal effect of working electronic chips, which consist of various heterostructures, an sonothermal‐responsive platform has been developed through constructing metal‐semiconductor interface on implants. Biofilm infection and deep vein thrombosis can be successfully treated by controllable ultrasound treatments.
Zhengdong Zhang, Pan Liu, Jie Lei, Shuchang Peng, Qiu Chen, Wei Guan, Yizhou Zhu, Gang Liu, Xiaobo Feng, Cao Yang, Lei Tan   +10 more
wiley   +1 more source

Aberrant mechanical loading induces annulus fibrosus cells apoptosis in intervertebral disc degeneration via mechanosensitive ion channel Piezo1

Arthritis Research & Therapy, 2023
Background Intervertebral disc degeneration (IVDD) is closely associated with the structural damage in the annulus fibrosus (AF). Aberrant mechanical loading is an important inducement of annulus fibrosus cells (AFCs) apoptosis, which contributes to the ...
Chenhao Liu, Xiaoxin Gao, Jinhui Lou, Haiyin Li, Yuxuan Chen, Molong Chen, Yuyao Zhang, Zhilei Hu, Xian Chang, Menglin Luo, Yu Zhai, Changqing Li   +11 more
doaj   +1 more source

PIEZO1 and TRPV4, which Are Distinct Mechano-Sensors in the Osteoblastic MC3T3-E1 Cells, Modify Cell-Proliferation

, 2019
Mechanical-loading and unloading can modify osteoblast functioning. Ca2+ signaling is one of the earliest events in osteoblasts to induce a mechanical stimulus, thereby demonstrating the importance of the underlying mechanical sensors for the sensation ...
Hiroka Suzuki, Miyazawa, Ken, Goto, Shigemi, Nakano, Sayumi, Shigemi Goto, Maki Yoneda, Katsuhiko Muraki, Suzuki, Hiroka, Muraki, Katsuhiko, Yukiko Muraki, Ken Miyazawa, Sayumi Nakano, Yoneda, Maki, Muraki, Yukiko, Noriyuki Hatano, Hatano, Noriyuki   +15 more
core   +1 more source

A Microenvironment‐Adaptive Scaffold Rejuvenates Peripheral Nerve Regeneration During Aging Via Dual Modulation of Ferroptotic Stimuli in Schwann Cells

Advanced Science, EarlyView.
(i) Aging impairs peripheral nerve regeneration via its dual ferroptosis‐mediated pathologies in senescent schwann cells. (ii) The composite nerve conduit is a symbiosis niche integrating microenvironment‐responsive nanoparticles (Ga‐PTAs) and maxillofacial‐derived mesenchymal stem cells (Mmscs).
Ning Zhan, Lixin Tian, Lianjie Peng, Jingyu Zhang, Lining Lin, Xiaoting Zhang, Yaxian Luo, Zhichao Liu, Xinhua Yao, Mouyuan Sun, Yong He, Mengfei Yu, Huiming Wang   +12 more
wiley   +1 more source

Piezo1 selectively enhances TGF-β1-induced IgA class switching by B cells

Cellular and Molecular Life Sciences
Piezo1 is a mechanosensitive cationic channel that regulates Ca2+ influx, gene transcription, and cell migration. Recent studies suggest that Piezo1 affects regulatory T cells differentiation and is critical in B cell responses to membrane-presented ...
Yoonji Jung, Younghwan Han, Jaeku Kang, Seong-Lan Yu, Seok-Rae Park   +4 more
doaj   +1 more source

Piezo1: structural pharmacology and mechanotransduction mechanisms

Trends in Pharmacological Sciences
Piezo1, a mechanosensitive ion channel protein, is a highly promising target for drug development. We systematically review the latest advances in its structural features, signal transduction mechanisms, and functional roles in various pathological processes including neurological diseases, cardiovascular diseases, and cancer.
Junyu Wang, Fangyuan Jing, Yinuo Zhao, Zilong You, Anren Zhang, Shugang Qin   +5 more
openaire   +2 more sources

Piezo1 promotes intervertebral disc degeneration through the Ca2+/F-actin/Yap signaling axis

Molecular Medicine
Background Piezo1 is a mechanically sensitive cation channel expressed in various tissues of the human body and has multiple roles in both physiological and pathological processes.
Fushuai Peng, Mingtong Sun, Xingzhi Jing, Fei Chen, Tong Cao, Zhenzhen Li, Tao Li   +6 more
doaj   +1 more source

Bioinformatics analysis of the association between hsa-miR-101-3p–induced downregulation of PIEZO1 and poor prognosis in head and neck squamous cell carcinoma mediated by the focal adhesion pathway

Oncology and Translational Medicine
. Background. In regard to head and neck squamous cell carcinoma (HNSC), a common type of head and neck malignant tumor with high mortality, the role of Piezo-type mechanosensitive ion channel component 1 (PIEZO1) is poorly understood.
Wei Dong, Hongquan Wei, Lingdi Duan, Hongguang Hu, Min Zhao   +4 more
doaj   +1 more source

Mechanosensitive Ion Channel Piezo1 Regulates Diet-Induced Adipose Inflammation and Systemic Insulin Resistance

Frontiers in Endocrinology, 2019
Adipocytes function as an energy buffer and undergo significant size and volume changes in response to nutritional cues. This adipocyte plasticity is important for systemic lipid metabolism and insulin sensitivity.
Can Zhao, Can Zhao, Can Zhao, Can Zhao, Qiushi Sun, Qiushi Sun, Lingyi Tang, Lingyi Tang, Yang Cao, Jamison L. Nourse, Medha M. Pathak, Xiang Lu, Xiang Lu, Xiang Lu, Qin Yang   +14 more
doaj   +1 more source