Results 61 to 70 of about 10,071 (256)

Nanovesicles With Mechanically Induced Adjuvanticity for Robust Melanoma Vaccination Toward Tumor‐Associated Macrophages

Advanced Science, EarlyView.
Rigidity‐tunable nanovesicle (P‐Pm) with mechanically induced adjuvanticity toward tumor‐associated macrophages (TAMs) was designed to engineer R848/gp100 antigen ‐loaded nanovaccine (P@Rg‐Pm), which achieved outstanding anti‐tumor outcomes in both therapeutic and preventive model of B16‐F10 melanoma.
Bangyue Luo, Liyan Qiu
wiley   +1 more source

Reversal of Stress‐Induced PIEZO1 Elevation with Mechanically Adapted Epicardial Patch for Myocardial Infarction Treatment

Advanced Science
Elevated expression of the mechanosensitive ion channel PIEZO1 in response to abnormal mechanical stimuli is implicated in many diseases, including myocardial infarction (MI).
Yuwen Lu, Sibo Jiang, Ting Shen, Yuan Zhang, Chengbin He, Yun Gao, Liyin Shen, Qiao Jin, Yuting Zhao, Ping Liang, Chaochen Wang, Hongjie Hu, Jin He, Kaicheng Deng, Shuo Wang, Yunhe Chen, Jun Ling, Yang Zhu, Lenan Zhuang   +18 more
doaj   +1 more source

B Cells are Activated via a Nanoporous Interface that Stabilizes Microvilli and Engages Mechanosensitive Ion Channels

Advanced Science, EarlyView.
B cells can be activated independently of antigen recognition via mechanical stimulation through nanoporous substrates. Exposure to such substrates induced B cell microvilli extension into the pores, intracellular Ca2+ signaling, phosphorylation of signaling proteins, and CD69 expression.
Nozie D. Aghaizu, Willi Weber, Nadine Strempel, Asya Polat, Enrico Klotzsch   +4 more
wiley   +1 more source

Endothelial Piezo1 channels as sensors of exercise [PDF]

The Journal of Physiology, 2018
Abstract Piezo1 channels are newly discovered ion channels which have come to the fore as players in endothelial biology. They have a key role as sensors of shear stress, a frictional force which arises in vascular biology because of blood flow.
openaire   +3 more sources

Mechanically activated Piezo1 channels of cardiac fibroblasts stimulate p38 mitogen-activated protein kinase activity and interleukin-6 secretion [PDF]

, 2019
Piezo1 is a mechanosensitive cation channel with widespread physiological importance; however, its role in the heart is poorly understood. Cardiac fibroblasts help preserve myocardial integrity and play a key role in regulating its repair and remodeling ...
Stylianidis, Vasili, Beech, David J., Gilbert, Hamish TJ, Drinkhill, Mark J., Swift, J, Li, J, Evans, EL, Cuthbertson, K, Evans, Elizabeth L, Turner, Neil A, van Nieuwenhoven, Frans A., Beech, DJ, Drinkhill, MJ, Porter, Karen E, Porter, Karen E., Gilbert, Hamish T.J., Gilbert, Hamish T. J., Ludlow, MJ, Blythe, NM, Gilbert, Hamish T J, Ludlow, Melanie J., Beech, David J, van Nieuwenhoven, FA, Stylianidis, V, Blythe, Nicola M, Drinkhill, Mark J, Foster, Richard, Li, Jing, Ludlow, Melanie J, Cuthbertson, Kevin, Turner, Neil A., Gilbert, HTJ, Porter, KE, Muraki, Katsuhiko, Blythe, Nicola M., Evans, Elizabeth L., Turner, NA, van Nieuwenhoven, Frans A, Swift, Joe; id_orcid, Foster, R, Muraki, K, Swift, Joe   +41 more
core   +1 more source

Improved PIEZO1 agonism through 4-benzoic acid modification of Yoda1 [PDF]

, 2023
Background and Purpose PIEZO1 forms mechanically activated calcium-permeable non-selective cation channels in numerous species and cell types. Options for pharmacological modulation are limited and so we modified a PIEZO1 small-molecule agonist (Yoda1 ...
Andrea Brüggemann, Debant, M, Jacob A. Kinsella, Bartoli, F, Oleksandr V. Povstyan, Cuthbertson, K, Lichtenstein, L, David J. Beech, Revill, CH, Beech, DJ, Maria Giustina Rotordam, Richard Foster, Melanie J. Ludlow, Murciano, N, Maria Giustina, R, Kinsella, JA, Endesh, N, Ludlow, MJ, Laeticia Lichtenstein, Povstyan, OV, Marjolaine Debant, Kevin Cuthbertson, Parsonage, G, Naima Endesh, Chuntharpursat-Bon, E, Gregory Parsonage, Fiona Bartoli, Charlotte H. Revill, Timothy Simon Futers, Eulashini Chuntharpursat‐Bon, Hyman, AJ, Becker, N, Foster, R, Adam J. Hyman, Nadine Becker, Futers, TS, Nicoletta Murciano, Brueggemann, A   +37 more
core   +1 more source

Bioadhesive‐Integrated 3D‐Printed Multilayer Scaffolds Secure a Mechanically‐Stable Osteoimmune Niche for Enhanced Bone Augmentation

Advanced Science, EarlyView.
A 3D‑printed multilayer adhesive scaffold, firmly anchored to bone defects by simple finger pressing, suppresses micromotion and secures mechanical stability of the osteogenic niche. This stabilization likely contributes to the enhanced bone augmentation by fostering a pro‑regenerative mechano‐immune profile—characterized by M2‑like macrophage ...
Delu Zhao, Qiuyi Li, Lingyun Wang, Chongao Zhang, Yutian Cheng, Shuang Liu, Fulan Wei, Zheqin Dong   +7 more
wiley   +1 more source

Piezo1 mutant zebrafish as a model of idiopathic scoliosis

Frontiers in Genetics, 2023
Scoliosis is a condition where the spine curves sideways, unique to humans due to their upright posture. However, the cause of this disease is not well understood because it is challenging to find a model for experimentation.
Ramli, Toshihiro Aramaki, Toshihiro Aramaki, Masakatsu Watanabe, Shigeru Kondo   +4 more
openaire   +3 more sources

Piezo1 expression in chondrocytes controls endochondral ossification and osteoarthritis development

Bone Research
Piezo proteins are mechanically activated ion channels, which are required for mechanosensing functions in a variety of cell types. While we and others have previously demonstrated that the expression of Piezo1 in osteoblast lineage cells is essential ...
Laura J. Brylka, Assil-Ramin Alimy, Miriam E. A. Tschaffon-Müller, Shan Jiang, Tobias Malte Ballhause, Anke Baranowsky, Simon von Kroge, Julian Delsmann, Eva Pawlus, Kian Eghbalian, Klaus Püschel, Astrid Schoppa, Melanie Haffner-Luntzer, David J. Beech, Frank Timo Beil, Michael Amling, Johannes Keller, Anita Ignatius, Timur A. Yorgan, Tim Rolvien, Thorsten Schinke   +20 more
doaj   +1 more source

Piezo1 Regulates Fibrocartilage Stem Cell In Cartilage Growth And Osteoarthritis

International Dental Journal
Aim or purpose: This study investigates the mechanotransductive role of Piezo1 in fibrocartilage stem cells (FCSCs) during temporomandibular joint (TMJ) development and osteoarthritis pathogenesis, addressing a critical gap in understanding how ...
Xinyu Wang
doaj   +1 more source