Results 41 to 50 of about 10,071 (256)

Recent advances in the pathophysiology of PIEZO1-related hereditary xerocytosis

, 2021
International audienceHereditary xerocytosis is a rare red blood cell disease related to gain-of-function mutations in the FAM38A gene, encoding PIEZO1, in 90% of cases; PIEZO1 is a broadly expressed mechano-transducer that plays a major role in many ...
Véronique Picard, Guitton, Corinne, Ouled-Haddou, Hakim, Loïc Garçon, Alexis Caulier, Lebon, Delphine, Djordjevic, Stefan, Jankovsky, Nicolas, Caulier, Alexis, Demagny, Julien, Nicolas Jankovsky, Picard, Veronique, Hakim Ouled‐Haddou, Delphine Lebon, Corinne Guitton, Julien Demagny, Stefan Djordjevic, Garcon, Loic   +17 more
core   +1 more source

Pharmacology of PIEZO1 channels

British Journal of Pharmacology
AbstractPIEZO1 is a eukaryotic membrane protein that assembles as trimers to form calcium‐permeable, non‐selective cation channels with exquisite capabilities for mechanical force sensing and transduction of force into effect in diverse cell types that include blood cells, endothelial cells, epithelial cells, fibroblasts and stem cells and diverse ...
Kinsella, J.A., Debant, M., Parsonage, G., Morley, L.C., Bajarwan, M., Revill, C., Foster, R., Beech, D.J.   +7 more
openaire   +4 more sources

A Microglia-Astrocyte Signaling Axis Regulates Astrocyte Piezo1 Expression and Inflammatory Responses. [PDF]

Glia
Activated microglia‐derived inflammatory signals drive astrocytic Piezo1 expression in both in vitro and in vivo models. Piezo1 upregulation modulates astrocytic Ca2+ dynamics and inflammatory gene expression, thereby limiting microglial activation. ABSTRACT Structural tissue alterations in numerous brain disorders can initiate mechanosensory signaling
Bai Y, Choi HB, Wendt S, Towriss M, Lin AJ, Groten CJ, Cui I, Nygaard HB, MacVicar BA.   +8 more
europepmc   +2 more sources

Pharmacological activation of PIEZO1 in human red blood cells prevents Plasmodium falciparum invasion

, 2023
International audienceAn inherited gain-of-function variant (E756del) in the mechanosensitive cationic channel PIEZO1 was shown to confer a significant protection against severe malaria.
Dominique Douguet, Allegrini, Benoit, Manouk Abkarian, Douguet, Dominique, Rachel Cerdan, Cerdan, Rachel, Lohia, Rakhee, Benoit Allegrini, Eric Honoré, Abkarian, Manouk, Kai Wengelnik, Laurence Berry, Rakhee Lohia, Hélène Guizouarn, Berry, Laurence, Wengelnik, Kai, Guizouarn, Hélène, Honoré, Eric   +17 more
core   +1 more source

Piezo1 activation facilitates ovarian cancer metastasis via Hippo/YAP signaling axis

Channels, 2022
Ovarian cancer (OC) is a highly malignant cancer with great metastatic potential. Here we aimed to investigate the role of Piezo1, a gene related to the mechanical environment of the tumor, in promoting the metastasis of OC. We performed Piezo1 knockdown
Yanjie Xiong, Liru Dong, Yun Bai, Hui Tang, Shuang Li, Dan Luo, Fang Liu, Jie Bai, Shikun Yang, Xudong Song   +9 more
doaj   +1 more source

Piezo1 deletion mitigates diabetic cardiomyopathy by maintaining mitochondrial dynamics via ERK/Drp1 pathway

Cardiovascular Diabetology
Objective Increasing evidence highlights the critical role of Piezo1 in cardiovascular diseases, with its expression upregulated in diabetic heart. However, the involvement of Piezo1 in the pathogenesis of diabetic cardiomyopathy (DCM) remains unclear ...
Weipin Niu, Xin Liu, Bo Deng, Tianying Hong, Cuifen Wang, Yameng Yan, Jiali Liu, Yuehua Jiang, Jing Li   +8 more
doaj   +1 more source

Mechanical stretch promotes hypertrophic scar formation through mechanically activated cation channel Piezo1

Cell Death and Disease, 2021
Hypertrophic scar (HS) formation is a skin fibroproliferative disease that occurs following a cutaneous injury, leading to functional and cosmetic impairment. To date, few therapeutic treatments exhibit satisfactory outcomes.
Jiahao He, Bin Fang, Shengzhou Shan, Yun Xie, Chuandong Wang, Yifan Zhang, Xiaoling Zhang, Qingfeng Li   +7 more
doaj   +1 more source

Engineering Piezo1-Mediated Calcium Signalling for Enhanced Extracellular Vesicle Biogenesis and Cargo Loading. [PDF]

J Extracell Biol
ABSTRACT Cell‐derived extracellular vesicles (EVs) are promising nanocarriers for therapeutic delivery platforms owing to their biocompatibility and capacity to protect and efficiently transport bioactive molecules. However, EV‐based therapeutics remain constrained by inefficient cargo loading and low production yields, which limit scalable ...
Saleh NA, Shafiq R, Cicerone AP, Kilangodi S, Hartwig H, Mias GI, Lu G, Huh JR, Li W, Deng CX, Kanada M.   +10 more
europepmc   +2 more sources

Chemical activation of the mechanotransduction channel Piezo1

eLife, 2015
Piezo ion channels are activated by various types of mechanical stimuli and function as biological pressure sensors in both vertebrates and invertebrates. To date, mechanical stimuli are the only means to activate Piezo ion channels and whether other modes of activation exist is not known. In this study, we screened ∼3.25 million compounds using a cell-
Syeda, Ruhma, Xu, Jie, Dubin, Adrienne, Coste, Bertrand, Mathur, Jayanti, Huynh, Truc, Matzen, Jason, Lao, Jianmin, Tully, David, Engels, Ingo, Petrassi, H Michael, Schumacher, Andrew, Montal, Mauricio, Bandell, Michael, Patapoutian, Ardem   +14 more
openaire   +4 more sources

Keratinocyte PIEZO1 modulates cutaneous mechanosensation

eLife, 2022
Epidermal keratinocytes mediate touch sensation by detecting and encoding tactile information to sensory neurons. However, the specific mechanotransducers that enable keratinocytes to respond to mechanical stimulation are unknown. Here, we found that the mechanically-gated ion channel PIEZO1 is a key keratinocyte mechanotransducer.
Alexander R Mikesell, Olena Isaeva, Francie Moehring, Katelyn E Sadler, Anthony D Menzel, Cheryl L Stucky   +5 more
openaire   +3 more sources