Results 21 to 30 of about 10,071 (256)
Cancer Cell International, 2022 Background Piezo1 has been revealed to play a regulatory role in vascular development and progression of variety tumors. However, whether and how the progression of hepatocellular carcinoma (HCC) regulated by Piezo1 remains elusive.
Yi-ming Li +5 more
doaj +1 more source
Alternating Shear Force of Respiration Regulates Cell Interactions of Fibroblasts and Macrophages to Promote Soft Tissue Integration of Chest Wall Polyetheretherketone Implants. [PDF]
Adv Sci (Weinh)Given that PEEK chest wall implants induce shear force at the soft tissue‐implant interface due to respiratory motion in the early in vivo post‐implantation stage. We confirmed that this mechanical stimulus triggers the PIEZO1/ITGB1/YAP1 signalling axis in L929 and the STAT6/p‐STAT6 pathway in RAW264.7, which in turn mediates adhesion and migration of ...
Huang R +14 more
europepmc +2 more sources
PIEZO1 transduces mechanical itch in mice
Nature, 2022 Abstract Itch triggers scratching, a behavioural defence mechanism that aids in the removal of harmful irritants and parasites 1 . Chemical itch is triggered by many endogenous and exogenous cues, such as pro-inflammatory histamine, which is released during an allergic ...
Rose Z. Hill +4 more
openaire +2 more sources
Piezo1-mediated fluid shear stress promotes OPG and inhibits RANKL via NOTCH3 in MLO-Y4 osteocytes
, 2022 Piezo1, a mechanosensitive ion channel, participates in a variety of biological processes in maintaining bone homeostasis. As the most abundant cells in bones of the mammals, osteocytes play an essential role in bone formation, remodeling, and bone mass ...
Xuening Liu (9079852) +11 more
core +1 more source
Functions of mutant and wildtype Piezo1 channels [PDF]
, 2019 Background: Piezo1 is a mechanically-activated ion channel with a widespread role in mechanotransduction in mammalian physiology. Mutations of the channel which confer gain of function (GOF) are causative of dehydrated hereditary stomatocytosis (DHS), a
Evans, Elizabeth Louise
core +5 more sources
PIEZO1 Channel Is a Potential Regulator of Synovial Sarcoma Cell-Viability [PDF]
, 2018 Detection of mechanical stress is essential for diverse biological functions including touch, audition, and maintenance of vascular myogenic tone. PIEZO1, a mechano-sensing cation channel, is widely expressed in neuronal and non-neuronal cells and is ...
Hiroka Suzuki +9 more
core +1 more source
Piezo1 Channels Are Inherently Mechanosensitive
Cell Reports, 2016 The conversion of mechanical force to chemical signals is critical for many biological processes, including the senses of touch, pain, and hearing. Mechanosensitive ion channels play a key role in sensing the mechanical stimuli experienced by various cell types and are present in organisms from bacteria to mammals.
Syeda, R +6 more
openaire +4 more sources
Reevaluation of Piezo1 as a gut RNA sensor
eLife, 2022 Piezo1 is a stretch-gated ion channel required for mechanosensation in many organ systems. Recent findings point to a new role for Piezo1 in the gut, suggesting that it is a sensor of microbial single-stranded RNA (ssRNA) rather than mechanical force. If true, this would redefine the scope of Piezo biology.
Alec R Nickolls +6 more
openaire +3 more sources
Frontiers in Physiology, 2022 Piezo1 is a membrane nonspecific cation channel involved in red blood cells (RBCs) in the regulation of their volume. Recently, it was shown that it is distributed on the RBC membrane in a nonuniform manner.
Bojan Božič +2 more
doaj +1 more source
Microbial RNAs Pressure Piezo1 to Respond [PDF]
Cell, 2020 Serotonin production by enterochromaffin cells (ECs) is microbiota-dependent, but the mechanism of this is unknown. In this issue of Cell, Sugisawa et al. demonstrate that Piezo1 in ECs senses single-strand RNA (ssRNA) from intestinal microbiota to promote serotonin production.
Juan D, Matute +2 more
openaire +2 more sources