Results 11 to 20 of about 10,071 (256)

Oxidative Modulation of Piezo1 Channels

Redox Biology
Emerging evidence suggests that mechanosensitive Piezo1 channels play a role in the pathomechanism of various disorders. However, the mechanisms by which accumulating pathologies regulate Piezo1 activation remain unclear. Oxidative stress, a common feature of neurodegenerative diseases, is associated with generation of reactive oxygen species (ROS ...
Novosolova N., Braidotti N., Patinen T., Laitinen T., Ciubotaru C., Huttunen K. M., Levonen A. L., Cojoc D., Giniatullin R., Malm T.   +9 more
openaire   +5 more sources

The Role of the Piezo1 Mechanosensitive Channel in Heart Failure

Current Issues in Molecular Biology, 2023
Mechanotransduction (MT) is inseparable from the pathobiology of heart failure (HF). However, the effects of mechanical forces on HF remain unclear. This review briefly describes how Piezo1 functions in HF-affected cells, including endothelial cells (ECs)
Weihua Yuan, Xicheng Zhang, Xiangming Fan   +2 more
doaj   +2 more sources

Piezo1 in Digestive System Function and Dysfunction

International Journal of Molecular Sciences, 2023
Piezo1, a non-selective cation channel directly activated by mechanical forces, is widely expressed in the digestive system and participates in biological functions physiologically and pathologically. In this review, we summarized the latest insights on Piezo1’s cellular effect across the entire digestive system, and discussed the role of Piezo1 in ...
Jing He, Xiaotian Xie, Zhuanglong Xiao, Wei Qian, Lei Zhang, Xiaohua Hou   +5 more
openaire   +3 more sources

Targeted knockdown of Piezo1 in synovial macrophages attenuates osteoarthritis development

Journal of Orthopaedic Translation
Objective: Osteoarthritis (OA) is a prevalent degenerative joint disease worldwide. Emerging therapies targeting the crosstalk between immune/inflammatory cells and chondrocytes have shown promise.
Zijian Yan, Dengying Wu, Haiyue Zhao, Haitao Guan, Jianpeng Chen, Chengbin Huang, Xuankuai Chen, Xiangtian Deng, Jinglue Hu, Juan Wang, Yingze Zhang   +10 more
doaj   +2 more sources

Matrix Stiffness Orchestrates Mesenchymal Stem Cell Lineage Commitment Toward Osteogenesis and Adipogenesis Through the PIEZO1/SP1/STC2 Axis. [PDF]

Adv Sci (Weinh)
Matrix stiffness directs mesenchymal stem cell lineage commitment through PIEZO1‐dependent activation of the SP1/STC2 pathway. Stiff matrices favor osteogenesis and suppress adipogenesis, whereas the loss of PIEZO1 function impairs early bone formation. STC2 retains lineage‐regulatory activity even when PIEZO1 is inactive.
Zhang S, Li S, Chen W, Song Q, Zhao H, Wang P, Zhang Y, Liang W, Zheng S, Wang J, Chen W, Zhu Y, Zhang Y.   +12 more
europepmc   +2 more sources

Piezo1 [PDF]

Channels, 2012
Piezo ion channels have been found to be essential for mechanical responses in cells. These channels were first shown to exist in Neuro2A cells, and the gene was identified by siRNAs that diminished the mechanical response. Piezo channels are approximately 2500 amino acids long, have between 24-32 transmembrane regions, and appear to assemble into ...
Gottlieb, Philip A., Sachs, Frederick
openaire   +2 more sources

The Piezo1 hypothesis of renal anemia

FASEB BioAdvances, 2022
AbstractErythropoietin deficiency is an extensively researched cause of renal anemia. The etiology and consequences of shortened red blood cell (RBC) life span in chronic kidney disease (CKD) are less well understood. Traversing capillaries requires RBC geometry changes, a process enabled by adaptions of the cytoskeleton.
Peter Kotanko, David J. Jörg, Nadja Grobe, Christoph Zaba   +3 more
openaire   +3 more sources

Modulators of Piezo1

, 2019
Piezo1 is a mechanosensitive ion channel involved in vascular development, stem cell lineation and endothelial cell homeostasis. It allows movement of cations into the cell in response to mechanical forces, such as membrane stretching.
Cuthbertson, Kevin
core   +5 more sources

Endothelial Piezo1: Life depends on it [PDF]

Channels, 2015
Endothelial cells are fundamental to almost all physiology: foundation stones of an ancient vascular system, essential for the development and survival of animals.
Jing, Li, Bing, Hou, David J, Beech
openaire   +2 more sources

Human PIEZO1: Removing Inactivation [PDF]

Biophysical Journal, 2013
PIEZO1 is an inactivating eukaryotic cation-selective mechanosensitive ion channel. Two sites have been located in the channel that when individually mutated lead to xerocytotic anemia by slowing inactivation. By introducing mutations at two sites, one associated with xerocytosis and the other artificial, we were able to remove inactivation. The double
Bae, Chilman, Gottlieb, Philip A., Sachs, Frederick   +2 more
openaire   +2 more sources