Results 1 to 10 of about 10,071 (256)

Piezo1 channel: structure, mechanogating mechanism, functions, diseases and therapeutic strategy [PDF]

Molecular Biomedicine
The Piezo1 channel is a mechanosensitive, non-selective cation channel that converts mechanical forces into electrochemical signals, playing pivotal roles in vertebrate physiology.
Qixiang Wu, Ying Hu, Yuhan Wang, Fuqiang Zhu, Qiongyu Xu, Ling Xu, Jinguo Xu, Tao Xu   +7 more
doaj   +3 more sources

Piezo1 and its inhibitors: Overview and perspectives [PDF]

European Journal of Medicinal Chemistry
The cation channel Piezo1, a crucial mechanotransducer found in various organs and tissues, has gained considerable attention as a therapeutic target in recent years. Following this trend, several Piezo1 inhibitors have been discovered and studied for potential pharmacological properties.
Tien-Anh Duong, Daniel Baecker
exaly   +4 more sources

Piezo1 Regulates the Skeletal Muscle Length–Tension Relationship Through Channel-Independent Mechanotransduction [PDF]

Biomolecules
Piezo1 mechanosensitive ion channels convert mechanical stimuli into biochemical signals across diverse tissues, yet their role in the contractile function of adult skeletal muscle remains unclear.
Beatrix Dienes, Áron Gere, Péter Szentesi, László Szabó, Zsigmond Máté Kovács, Zsuzsanna Édua Magyar, Eliza Guti, Tamás Bazsó, Mónika Gönczi, László Csernoch   +9 more
doaj   +2 more sources

Piezo1 Impairs Endothelial Barrier and Drives Aortic Aneurysm and Dissection via STAT3-Dependent Activation of the CCL2–CCR2 Axis [PDF]

Research
Endothelial cells (ECs) sense hemodynamic forces and critically influence aortic aneurysm and dissection (AAD) development. However, the possible contribution of the mechanical sensor Piezo1 to AAD remains elusive.
Kehui Yang, Yang Liu, Xiaoran Huang, Dehui Hou, Han Du, Jingwen Wang, Hongwei Yue, Yunyun Guo, Sumei Cui, Huidan Zhang, Yijun Sun, Xin Li, Jun Ren, Feng Xu, Yuguo Chen   +14 more
doaj   +2 more sources

PIEZO1 enhances pancreatic cancer neurotropism

Cancer Cell International
Perineural invasion (PNI), as a prominent feature of pancreatic ductal adenocarcinoma, is closely related to poor prognosis and urgently needs to be investigated mechanisms to find effective intervention measures.
Jinhong Li, Qicai Liu, Renfeng Xu, Juan Tang, Ling Wang, Yuqing Zheng, Shangeng Weng, Feng Gao   +7 more
doaj   +3 more sources

Expression of Piezo1 in the Trigeminal Neurons and in the Axons That Innervate the Dental Pulp

Frontiers in Cellular Neuroscience, 2022
Information on the neurons and axons that express the mechanosensitive channel Piezo1 and its expression in axons innervating the dental pulp may help understand the nature of the Piezo1-mediated mechanosensation and the underlying mechanism of dentin ...
Yi Sul Cho, Hye Min Han, Soon Youn Jeong, Tae Heon Kim, So Young Choi, Yun Sook Kim, Yong Chul Bae   +6 more
doaj   +1 more source

Inhibition of Piezo1 Ameliorates Intestinal Inflammation and Limits the Activation of Group 3 Innate Lymphoid Cells in Experimental Colitis

Journal of Innate Immunity, 2023
Piezo1, the mechanosensory ion channel, has attracted increasing attention for its essential roles in various inflammatory responses and immune-related diseases. Although most of the key immune cells in inflammatory bowel disease (IBD) have been reported
Chang Liu, Yanan Xia, Shichen Fu, Fanyi Meng, Bingcheng Feng, Leiqi Xu, Lixiang Li, Xiuli Zuo   +7 more
doaj   +1 more source

Optical control of PIEZO1 channels

Nature Communications, 2023
AbstractPIEZO proteins are unusually large, mechanically-activated trimeric ion channels. The central pore features structural similarities with the pore of other trimeric ion channels, including purinergic P2X receptors, for which optical control of channel gating has been previously achieved with photoswitchable azobenzenes.
Peralta, Francisco Andrés, Balcon, Mélaine, Martz, Adeline, Biljali, Deniza, Cevoli, Federico, Arnould, Benoit, Taly, Antoine, Chataigneau, Thierry, Grutter, Thomas   +8 more
openaire   +3 more sources

Yoda1 Activates Piezo1 in Vitro to Simulate the Upregulation of Piezo1 in the Infected Brain: Piezo1 Participates in the Immune Activation of Microglia. [PDF]

, 2021
Abstract Aim: The expression of Piezo1 in reactive glial cells in the peripherally infected patient's brain was upregulated. This study aimed to determine whether Piezo1 is involved in the immune activation of microglial cells induced by bacterial lipopolysaccharides.Materials and methods: BV2 cells were used as a model of brain microglia.
Heguo Luo, Hailin Liu, Wengong Bian, Bochao Chen, Dongxia Yang, Mingmin Yang   +5 more
openaire   +1 more source

Adherent cell remodeling on micropatterns is modulated by Piezo1 channels

Scientific Reports, 2021
Adherent cells utilize local environmental cues to make decisions on their growth and movement. We have previously shown that HEK293 cells grown on the fibronectin stripe patterns were elongated.
Deekshitha Jetta, Mohammad Reza Bahrani Fard, Frederick Sachs, Katie Munechika, Susan Z. Hua   +4 more
doaj   +1 more source