Results 31 to 40 of about 10,071 (256)
Piezo1-Regulated Mechanotransduction Controls Flow-Activated Lymphatic Expansion [PDF]
, 2022 BackgroundMutations in PIEZO1 (Piezo type mechanosensitive ion channel component 1) cause human lymphatic malformations. We have previously uncovered an ORAI1 (ORAI calcium release-activated calcium modulator 1)-mediated mechanotransduction pathway that ...
Cho, Il-Taeg +24 more
core +1 more source
PIEZO1 expression at the glio-vascular unit adjusts to neuroinflammation in seizure conditions
Neurobiology of Disease, 2023 Mechanosensors are emerging players responding to hemodynamic and physical inputs. Their significance in the central nervous system remains relatively uncharted. Using human-derived brain specimens or cells and a pre-clinical model of mesio-temporal lobe
Valentin Garcia +13 more
doaj +1 more source
Force-induced conformational changes in PIEZO1 [PDF]
Nature, 2019 PIEZO1 is a mechanosensitive channel that converts applied force into electrical signals. Partial molecular structures show that PIEZO1 is a bowl-shaped trimer with extended arms. Here we use cryo-electron microscopy to show that PIEZO1 adopts different degrees of curvature in lipid vesicles of different sizes.
Yi-Chih, Lin +5 more
openaire +2 more sources
Direct observation of the conformational states of PIEZO1
Nature, 2023 AbstractPIEZOs are mechanosensitive ion channels that convert force into chemoelectric signals1,2 and have essential roles in diverse physiological settings3. In vitro studies have proposed that PIEZO channels transduce mechanical force through the deformation of extensive blades of transmembrane domains emanating from a central ion-conducting pore4–8.
Eric M. Mulhall +10 more
openaire +2 more sources
Piezo1 channel activation mimics high glucose as a stimulator of insulin release [PDF]
, 2019 Glucose and hypotonicity induced cell swelling stimulate insulin release from pancreatic β-cells but the mechanisms are poorly understood. Recently, Piezo1 was identified as a mechanically-activated nonselective Ca2+ permeable cationic channel in a range
Kearney, MT +29 more
core +1 more source
Piezo1 regulates shear-dependent nitric oxide production in human erythrocytes
, 2022 Mature circulating red blood cells (RBC) are classically viewed as passive participants in circulatory function, given erythroblasts eject their organelles during maturation.
Kuck, Lennart +2 more
core +1 more source
Frontiers in Cell and Developmental Biology, 2022 A mechanosensitive ion channel, Piezo1 induces non-selective cation flux in response to various mechanical stresses. However, the biological interpretation and underlying mechanisms of cells resulting from Piezo1 activation remain elusive.
Heon-Su Kim +15 more
doaj +1 more source
Piezo1 in digestive homeostasis and disease: Barrier function, immune signalling, cellular injury and metabolism. [PDF]
Clin Transl MedPiezo1 functions as a context‐dependent mechanotransduction node linking mechanical cues to inflammation, tissue remodelling and metabolic regulation in digestive homeostasis and disease. In epithelial, immune, stromal and endocrine cells, Piezo1‐mediated Ca2+ signalling contributes to barrier and mucus homeostasis, epithelial renewal and repair ...
Xia Y +6 more
europepmc +2 more sources
Membrane curvature governs the distribution of Piezo1 in live cells [PDF]
, 2022 Piezo1 is a bona fide mechanosensitive ion channel ubiquitously expressed in mammalian cells. The distribution of Piezo1 within a cell is essential for various biological processes including cytokinesis, cell migration, and wound healing.
Wang, Matthew +14 more
core +1 more source
The function of Piezo1 in hepatoblastoma metastasis and its potential transduction mechanism
Heliyon, 2022 Background: Hepatoblastoma (HB) is the most common primary malignant liver tumor in children. The prognosis of HB metastasis is poor, despite the increasing diversity of treatment. Piezo, a ubiquitously expressed membrane mechano-transduction protein, is
Xiaoshuo Ye +6 more
doaj +1 more source