Results 71 to 80 of about 11,131 (244)

Elevated TRIM25 Impairs Poly (ADP‐ribose) Metabolism via PARG Degradation and Mediates Compression‐Induced Intervertebral Disc Degeneration

Advanced Science, EarlyView.
TRIM25 acts as a multifunctional hub driving intervertebral disc degeneration under mechanical stress. Mechanical compression significantly upregulates TRIM25 expression, establishing it as a key E3 ubiquitin ligase platform. TRIM25 targets PARG and Ku80 via distinct molecular interfaces, triggering their ubiquitination and degradation.
Zhangrong Cheng, Haiyang Gao, Wenbo Wu, Pengzhi Shi, Xianglong Chen, Zimu Yu, Wang Wu, Kangcheng Zhao, Cao Yang, Yukun Zhang   +9 more
wiley   +1 more source

Deciphering the complex signalling systems that regulate intestinal epithelial cell death processes and shedding [PDF]

, 2017
Intestinal epithelial cells play a fundamental role in maintaining homeostasis. Shedding of intestinal cells in a controlled manner is critical to maintenance of barrier function.
Agace, Albert, Anon, Arnold, Assi, Barker, Begnaud, Boehm, Brand, Brugués, Capaldo, Chen, Cheung, Du, Dunn, Dürer, Edelblum, Eisenhoffer, Elmore, Ericsson, Farooqui, George, Gilbert, Gu, Guan, Gudipaty, Günther, Günther, Günther, Heller, Hodge, Hughes, Kaemmerer, Kiesslich, Kim, Kocgozlu, Koch, Kofoed, Kuipers, Kumar, Le, Lhocine, Lindemans, Marchiando, Melendez, Nava, Niculescu, Parker, Patnaik, Pentecost, Pentecost, Peterson, Pruteanu, Rankin, Rauch, Ravasio, Sagulenko, Sellin, Smith, Solaymani-Mohammadi, Taylor, Ubelmann, Van Itallie, VanDussen, Wang, Wang, Wang, Watson, Williams, Wong   +69 more
core   +2 more sources

Mechanical Strain‐Programmed SDC1+ Sheath Fibroblasts Trigger CXCR4hi Neutrophil‐Mediated Enthesitis in Ankylosing Spondylitis

Advanced Science, EarlyView.
In ankylosing spondylitis (AS), mechanical strain‐programmed SDC1+ sheath fibroblasts secrete CXCL5 to recruit neutrophils and promote the activation of CXCR4hi neutrophils, thereby exacerbating enthesitis by promoting neutrophil extracellular traps (NETs) formation. SOX5 controls the generation of SDC1+ sheath fibroblasts via super‐enhancers.
Jiajie Lin, Zepeng Su, Yipeng Zeng, Yi Zhou, Chenying Zeng, Weihao Zhang, Qibo Li, Zipeng Xiao, Zibin Chen, Ziqian Liu, Yangfeng Lin, Guan Zheng, Wenhui Yu, Zhongyu Xie   +13 more
wiley   +1 more source

The Sirt1‐Piezo1 Axis Promotes Bone Formation and Repair in Mice

Advanced Science
The mechanosensitive Piezo1 channel protein plays a pivotal role in promoting bone formation and repair; however, its underlying molecular mechanism(s) are poorly defined.
Donghao Gan, Yi Ran, Hong Pan, Qinnan Yan, Wenjing Zhang, Bo Zhou, Pengzhi Xu, Rongdong Liao, Haipeng Xue, Will Jiang, Tailin He, Qingyun Jia, Lei Qin, Francis Y Lee, Di Chen, Chuanju Liu, Guozhi Xiao   +16 more
doaj   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Piezo1 Regulates Fibrocartilage Stem Cell In Cartilage Growth And Osteoarthritis

International Dental Journal
Aim or purpose: This study investigates the mechanotransductive role of Piezo1 in fibrocartilage stem cells (FCSCs) during temporomandibular joint (TMJ) development and osteoarthritis pathogenesis, addressing a critical gap in understanding how ...
Xinyu Wang
doaj   +1 more source

Bacterial mechanosensitive channels: models for studying mechanosensory transduction [PDF]

, 2014
Significance: Sensations of touch and hearing are manifestations of mechanical contact and air pressure acting on touch receptors and hair cells of the inner ear, respectively.
Battle, Andrew, Carne, Sonia, Chi, Gamma, Constantine, Maryrose, Cornell, Bruce, Cranfield, Charles G., Deplazes, Evelyne, Deplazes, Evelyne, Foo, Alexander, Hankamer, Ben, Landsberg, Michael J., Martinac, Boris, Nomura, Takeshi, Petrov, Evgeny, Rohde, Paul R., Rothnagel, Rosalba   +15 more
core   +2 more sources

Sensing and Reprogramming Surface Receptor Activation With Synthetic Transcriptional Circuits

Advanced Science, EarlyView.
A synthetic receptor‐signalling induced transcription (RESIT) circuit is designed based on receptor activation mediated split protease complementation and release of membrane‐tethered synthetic transcriptional modules. The RESIT system enables probing Ca2+ entry, receptor tyrosine kinase (RTK) activities and Ras activation, and reprogramming RTK ...
Fei Liu, Mei Yuan, Li‐Juan Tang, Fenglin Wang, Xia Chu, Jian‐Hui Jiang   +5 more
wiley   +1 more source

Piezo1 selectively enhances TGF-β1-induced IgA class switching by B cells

Cellular and Molecular Life Sciences
Piezo1 is a mechanosensitive cationic channel that regulates Ca2+ influx, gene transcription, and cell migration. Recent studies suggest that Piezo1 affects regulatory T cells differentiation and is critical in B cell responses to membrane-presented ...
Yoonji Jung, Younghwan Han, Jaeku Kang, Seong-Lan Yu, Seok-Rae Park   +4 more
doaj   +1 more source

Bioinformatics analysis of the association between hsa-miR-101-3p–induced downregulation of PIEZO1 and poor prognosis in head and neck squamous cell carcinoma mediated by the focal adhesion pathway

Oncology and Translational Medicine
. Background. In regard to head and neck squamous cell carcinoma (HNSC), a common type of head and neck malignant tumor with high mortality, the role of Piezo-type mechanosensitive ion channel component 1 (PIEZO1) is poorly understood.
Wei Dong, Hongquan Wei, Lingdi Duan, Hongguang Hu, Min Zhao   +4 more
doaj   +1 more source