Results 181 to 190 of about 5,132 (198)

Piezo2 expression in corneal afferent neurons

Journal of Comparative Neurology, 2014
ABSTRACTRecently, a novel class of mechanically sensitive channels has been identified and have been called Piezo channels. In this study, we explored Piezo channel expression in sensory neurons supplying the guinea pig corneal epithelium, which have well‐defined modalities in this species.
Romke, Bron, Rhiannon J, Wood, James A, Brock, Jason J, Ivanusic   +3 more
openaire   +2 more sources

Glans clitoris innervation: PIEZO2 and sexual mechanosensitivity

Journal of Anatomy, 2020
AbstractThe clitoris is a leading player in female sexual arousal, if not the main protagonist. Despite this role, studies performed on this structure with specific neuroanatomical techniques are few. This study focuses on glans clitoris innervation, with special emphasis on sensory corpuscles and the presence of the mechanotransducer protein PIEZO2 in
Yolanda García‐Mesa, Lucía Cárcaba, César Coronado, Ramón Cobo, José Martín‐Cruces, Jorge García‐Piqueras, Jorge Feito, Olivia García‐Suárez, José A. Vega   +8 more
openaire   +2 more sources

Lighting Up Mechanosensation: dyeing to see PIEZO2

2022
SUMMARYSensory neurons gather information about mechanical forces from both the environment and internal organs to regulate physiology. PIEZO2 is a mechanosensory ion channel critical for touch, proprioception and bladder stretch sensation, yet its broad expression in sensory neurons and elsewhere suggests it may have undiscovered physiological roles ...
Nicholas W. Villarino, Adrienne E. Dubin, Ardem Patapoutian, Kara L. Marshall   +3 more
openaire   +1 more source

Piezo2 Expression in Mechanosensitive Dental Primary Afferent Neurons

Journal of Dental Research, 2017
Mechanosensitive ion channels have been suggested to be expressed in dental primary afferent (DPA) neurons to transduce the movement of dentinal fluid since the proposal of hydrodynamic theory. Piezo2, a mechanosensitive, rapidly inactivating (RI) ion channel, has been recently identified in dorsal root ganglion (DRG) neurons to mediate tactile ...
J, Won, H, Vang, P R, Lee, Y H, Kim, H W, Kim, Y, Kang, S B, Oh   +6 more
openaire   +2 more sources

PIEZO2 in somatosensory neurons controls gastrointestinal transit

2022
SummaryThe gastrointestinal tract is in a state of constant motion. These movements are tightly regulated by the presence of food and help digestion by mechanically breaking down and propelling gut content. Mechanical sensing in the gut is thought to be essential for regulating motility; however, the identity of the neuronal populations, the molecules ...
M. Rocio Servin-Vences, Ruby M. Lam, Alize Koolen, Yu Wang, Dimah N. Saade, Meaghan Loud, Halil Kacmaz, Arthur Beyder, Kara L. Marshall, Carsten G. Bönnemann, Alexander T. Chesler, Ardem Patapoutian   +11 more
openaire   +1 more source

Piezo2 voltage-block regulates mechanical pain sensitivity

2022
AbstractPIEZO2 mechanosensitive channels are required for normal touch sensation. However, PIEZO2 channels are almost completely blocked at negative resting membrane potentials. We show that PIEZO2 voltage-block can be relieved by mutations at a conserved Arginine (R2756) which dramatically sensitizes the channel to mechanical stimuli.
Oscar Sánchez Carranza, Sampurna Chakrabarti, Johannes Kühnemund, Fred Schwaller, Valérie Bégay, Gary R. Lewin   +5 more
openaire   +1 more source

Piezo1 and Piezo2 collectively regulate jawbone development

Development
ABSTRACT Piezo1 and Piezo2 are recently reported mechanosensory ion channels that transduce mechanical stimuli from the environment into intracellular biochemical signals in various tissues and organ systems. Here, we show that Piezo1 and Piezo2 display a robust expression during jawbone development.
Xuguang Nie, Yasaman Abbasi, Man-Kyo Chung   +2 more
openaire   +2 more sources

The biophysics of piezo1 and piezo2 mechanosensitive channels

Biophysical Chemistry, 2016
The ability to sense mechanical stimuli and elaborate a response to them is a fundamental process in all organisms, driving crucial mechanisms ranging from cell volume regulation up to organ development or regeneration. Nevertheless, only in few cases the underlying molecular players are known.
Soattin L, Fiore M, Gavazzo P, Viti F, Facci P, Raiteri R, Difato F, Pusch M, Vassalli M   +8 more
openaire   +5 more sources

A novel suppressor of Piezo2 in rodent nociceptors

Trends in Neurosciences
Members of both the Piezo and transmembrane channel-like (TMC) families are bona fide mammalian mechanotransducers. In a recent study, Zhang, Shao et al. discovered that TMC7, a non-mechanosensitive TMC, inhibits Piezo2-dependent mechanosensation, with implications for the importance of cellular context for Piezo2 channels in normal and pathological ...
Aaron Keith West, Eve Rebecca Schneider
openaire   +2 more sources

Piezo2 sensory innervation during kidney development

Physiology
Piezo2 is a mechanically activated ion channel expressed in a subset of sensory neurons, including in the bladder. Our lab has recently mapped innervation of the developing kidney and found that renal nerve development begins at embryonic day 13.5 (E13.5) and is tightly aligned with smooth muscle actin (SMA+) arterial development.
Sarah McLarnon, Pierre N’Guetta, Adrien Tassou, Matan Geron, Gregory Scherrer, Lori L O'Brien   +5 more
openaire   +1 more source