Results 101 to 110 of about 4,669,551 (309)

Identification of hydroxyapatite spherules provides new insight into subretinal pigment epithelial deposit formation in the aging eye. [PDF]

, 2015
Accumulation of protein- and lipid-containing deposits external to the retinal pigment epithelium (RPE) is common in the aging eye, and has long been viewed as the hallmark of age-related macular degeneration (AMD).
Flinn, JM, Lanzirotti, A, McPhail, DS, Fearn, S, Ueffing, M, Boldt, K, Ratu, SG, Lengyel, I, Thompson, RB, Kortvely, E, Pauleikhoff, L, Bird, AC, Reffatto, V, Bundy, JG, Jones, EA   +14 more
core  

Structural Colors from Modulated Topological Defects in Molecular Smectic Liquid Crystals

Advanced Science, EarlyView.
Rather than using dyes and pigments, nature produces the colors of some butterflies and beetles through optical interference phenomena. This study describes an original biomimetic strategy exploiting the spontaneous formation of modulated linear defects in thin films of 8CB, a common molecular liquid crystal.
Camille N. Mahyaoui, Guilhem Poy, Rabab Zehra, Axel Fouques, Vassili Sergan, Ivan Dozov, Claire Meyer, Patrick Davidson   +7 more
wiley   +1 more source

Pigment-Cell Biology [PDF]

Nature, 1968
Advances in Biology of Skin Vol. 8: The Pigmentary System. (Proceedings of a Symposium held at the University of Oregon Medical School, 1966. Publication No. 183 from the Oregon Regional Primate Research Center.) Edited by William Montagna and Funan Hu. Pp. xxiii + 659. (Oxford, London and New York: Pergamon Press, 1967.) 210s.
openaire   +1 more source

Soft, Multi‐Wavelength Photoplethysmography Enables Reliable Neonatal Blood Pressure Monitoring Via Error Stratification

Advanced Science, EarlyView.
A soft hybrid multi‐wavelength PPG wearable acquires neonatal signals. Synchronized PPG and invasive ABP data are segmented into fixed windows. A 1D‐EfficientNet model predicts segment‐level SBP and DBP. Model performance is examined with retrospective subgroup analysis across acquisition conditions.
Wenqi Shi, Lanlan Mi, Jiarong Chen, Biao Liu, Min Wang, Zisheng Dai, Bin Liu, Ruize Gao, Yunfeng Lin, Weiwei Guo, Guoxing Wang, Wenyi Luo, Cheng Chen   +12 more
wiley   +1 more source

Negative regulators of angiogenesis, ocular vascular homeostasis, and pathogenesis and treatment of exudative AMD

Journal of Ophthalmic & Vision Research, 2018
Angiogenesis, the formation of new blood vessels from pre-existing capillaries, is very tightly regulated and normally does not occur except during developmental and reparative processes.
Mitra Farnoodian, Christine M Sorenson, Nader Sheibani   +2 more
doaj   +1 more source

Ultrasound-targeted microbubble destruction enhances AAV mediated gene transfection: human RPE cells in vitro and the rat retina in vivo [PDF]

, 2009
The present study was performed to investigate the efficacy and safety of Ultrasound-targeted microbubble destruction (UTMD) mediated rAAV2-EGFP to cultured human retinal pigment epithelium (RPE) cells _in vitro_ and the rat retina _in vivo_.
Xiaozhi Zheng, Huiping Wang, Ying Wu, Lianfang Du, Hongli Li, Fan Li   +5 more
core  

An Aggregation‐Induced Polymerization Poly(Disulfide)‐Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS‐STING Pathway

Advanced Science, EarlyView.
A cationic poly(disulfide)‐drug nanoplatform (LA/DexP) was developed to treat experimental autoimmune uveitis (EAU). With potent blood‐retinal barrier penetrability, LA/DexP releases DSP in response to high ROS and scavenges cfDNA to inhibit the cGAS‐STING signaling pathway.
Yuelan Wu, Wenbo Geng, Qinjin Dai, Wanyun Zhang, Yuxian Lai, Pei Zhang, Chunjiang Zhou, Yinuo Wang, Qingfeng Cao, Xiang Luo, Yujie Lai, Changwei Huang, Peizeng Yang   +12 more
wiley   +1 more source

The role of lipid in malaria pigment (Haemozoin) formation under biomimetic conditions [PDF]

, 2013
Includes bibliographical references.Previous studies have proposed lipids and/or proteins to be involved in the biomineralization process of haemozoin formation in the malaria parasite which is a target for many antimalarial drugs.
Ambele, Melvin Anyasi
core   +1 more source

Odorant Receptor 51E2 Agonist β-ionone Regulates RPE Cell Migration and Proliferation

Frontiers in Physiology, 2017
The odorant receptor 51E2 (OR51E2), which is well-characterized in prostate cancer cells and epidermal pigment cells, was identified for the first time as the most highly expressed OR in human fetal and adult retinal pigment epithelial (RPE) cells ...
Nikolina Jovancevic, Soumaya Khalfaoui, Markus Weinrich, Daniel Weidinger, Annika Simon, Benjamin Kalbe, Marcus Kernt, Anselm Kampik, Günter Gisselmann, Lian Gelis, Hanns Hatt   +10 more
doaj   +1 more source

Agouti protein, mahogunin, and attractin in pheomelanogenesis and melanoblast-like alteration of melanocytes: a cAMP-independent pathway [PDF]

, 2009
Melanocortin-1 receptor (MC1R) and its ligands, a-melanocyte stimulating hormone (aMSH) and agouti signaling protein (ASIP), regulate switching between eumelanin and pheomelanin synthesis in melanocytes.
Bennett, DC, Jimbow, K, Wakamatsu, Kazumasa, Elena V. Sviderskaya, Shosuke Ito, Montoliu, L, Andrew J. Donkin, Tokimasa Hida, Yu, B, Bin Yu, Lluis Montoliu, Donkin, AJ, Wakamatsu, K, Dorothy C. Bennett, Hida, T, Yu, Bin, Millhauser, Glenn L., Bennett, Dorothy C., Barsh, GS, Sviderskaya, Elena V., Sviderskaya, EV, Ito, Shosuke, Lamoreux, ML, Kazumasa Wakamatsu, M. Lynn Lamoreux, Glenn L. Millhauser, Kowichi Jimbow, Lynn Lamoreux, M, Donkin, Andrew J., Lamoreux, M. Lynn, Hida, Tokimasa, Montoliu, Lluís, Gregory S. Barsh, Millhauser, GL, Barsh, Gregory S., Ito, S, Jimbow, Kowichi   +36 more
core   +1 more source