Engineering Biology Beyond Single Genes: Advances and Challenges in Multiplex Genome Editing
Animal Research and One Health, EarlyView.Multiplex genome editing is transforming genome engineering from single‐gene perturbation to network‐level control, yet its broader application remains limited by challenges in gRNA array engineering, delivery technologies, and safety management. Emerging AI‐driven approaches are accelerating guide RNA design and CRISPR effector optimization for ...
Linli Wang, Yongbin Liu, Hongbing Han
wiley +1 more source
Extrinsic and intrinsic factors influencing amphibian pigment pattern formation
, 1959 Lehman, Harvey Eugene +3 more
core +1 more source
Investigating Pompeii Subsoil Using Geomatics and Geophysics Merged Analyses
Archaeological Prospection, EarlyView.ABSTRACT The archaeological site of Pompeii represents an exceptional context for the application of non‐invasive and integrated investigation methods aimed at enhancing the understanding of both exposed and buried remains. This study presents the results of multidisciplinary research conducted in the Palestra Grande site, a large and strategically ...
Valentina Santoro +9 more
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Tattoo-Induced Granulomatous Inflammation Presenting as Koebner Phenomenon in Psoriasis. [PDF]
Indian J DermatolHerlekar R, Sharma A, Dogra S.
europepmc +1 more source
Arthritis &Rheumatology, EarlyView.Objective To characterize the clinical, immunologic, and proteomic changes associated with CD19 chimeric antigen receptor T cell therapy in patients with progressive systemic sclerosis (SSc). Methods Patients with progressive SSc received CD19 chimeric antigen receptor (CAR)‐T cell therapy and were observed longitudinally for safety, clinical efficacy,
Chenhan Jia +16 more
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Statement of Retraction: Recombinant human klotho protects against hydrogen peroxide-mediated injury in human retinal pigment epithelial cells via the PI3K/Akt-Nrf2/HO-1 signaling pathway. [PDF]
Bioengineeredeuropepmc +1 more source
De novo coassembly of functional chlorophyll- and carotenoid-protein complexes in <i>Saccharomyces cerevisiae</i>. [PDF]
Sci AdvLi C, Chen GE.
europepmc +1 more source
Investigating the changes in skin color representation within US medical textbook imagery
Anatomical Sciences Education, EarlyView.Abstract Medical education traditionally relies on textbooks with limited representation of dark skin tones, contributing to “visual racism.” This study sought to answer: “To what extent has skin‐of‐color representation changed in widely used U.S. medical textbooks over twenty years?” Older and newer editions of four widely used medical textbooks were ...
Justin Lyon +4 more
wiley +1 more source
Mitochondrial outer membrane protein FUNDC2 contributes to ferroptosis as a potential upstream regulator in retinitis pigmentosa. [PDF]
Int J OphthalmolChen JY, Huang YF, Hong Y.
europepmc +1 more source
Video‐Assisted Intralesional Curettage for Invasive Nonmalignant Giant Cell Tumors
Arthroscopy Techniques, EarlyView.Abstract Giant cell tumor of bone is a locally aggressive benign neoplasm with a strong tendency for local recurrence after surgical treatment. Intralesional excision and curettage is preferred in most cases to maximize tumor removal while preserving the affected joint.
George Loria +5 more
wiley +1 more source