Results 101 to 110 of about 2,749,048 (351)
Autophagy regulates death of retinal pigment epithelium cells in age-related macular degeneration
Cell Biology and Toxicology, 2016 Age-related macular degeneration (AMD) is an eye disease underlined by the degradation of retinal pigment epithelium (RPE) cells, photoreceptors, and choriocapillares, but the exact mechanism of cell death in AMD is not completely clear.
K. Kaarniranta +4 more
semanticscholar +1 more source
Costello Syndrome and Ophthalmologic Issues: Unveiling the Unseen
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Costello syndrome (CS) is an ultra‐rare condition belonging to the RASopathies, a group of disorders characterized by aberrant RAS/MAPK pathway signaling, which is involved in ocular development and in some eye pathologies. However, only a few studies assessing the ophthalmic features of individuals with CS are available.
Sofia Peschiaroli +13 more
wiley +1 more source
Druse-Induced Morphology Evolution in Retinal Pigment Epithelium [PDF]
arXiv, 2016 The retinal pigment epithelium (RPE) is a key site of pathogenesis for many retina diseases. The formation of drusen in the retina is characteristic of retinal degeneration. We investigate morphological changes in the RPE in the presence of soft drusen using an integrated experimental and modeling approach. We collect RPE flat mount images from donated
arxiv
Revista Brasileira de Oftalmologia, 2014 Purpose: Register and compare anatomical changes, structural and quantitative found in optical coherence tomography Stratus and Topcon 3D in chronic users of chloroquine.
Celso Morita +5 more
doaj +1 more source
Animal Models and Experimental Medicine, EarlyView.The flowchart of this research. Abstract Background Dry eye disease (DED) predominantly results from elevated tear film osmolarity, which can not only cause ocular inconvenience but may lead to visual impairments, severely compromising patient well‐being and exerting substantial economic burdens as well.
Ziyu Liu +9 more
wiley +1 more source
A new microscopy for imaging retinal cells [PDF]
arXiv, 2017 The evaluation and monitoring of cells health in the human retina is crucial and follow time course of retinal diseases, detect lesions before irreversible visual loss and to evaluate treatment effects. Towards this goal, a major challenge is to image and quantify retinal cells in human eyes in a non-invasive manner.
arxiv
Retinal pigment epithelium cell density in relationship to axial length in human eyes [PDF]
Acta Ophthalmologica, 2016 AbstractPurposeTo assess associations between axial length and density of retinal pigment epithelium (RPE) cells in various ocular regions.MethodsThe histomorphometric investigation included histological sections of enucleated eyes of Caucasian patients. Using a light microscope, we counted the number of RPE cells on Bruch′s membrane at the ora serrata,
Jost B. Jonas +3 more
openaire +2 more sources
Journal of Biophotonics, 2018 A full quantitative evaluation of the depolarization of light may serve to assess concentrations of depolarizing particles in the retinal pigment epithelium and to investigate their role in retinal diseases in the human eye.
N. Lippok +5 more
semanticscholar +1 more source
Molecular Therapy: Nucleic Acids, 2017 Pigment epithelium derived factor (PEDF) is a potent antiangiogenic, neurotrophic, and neuroprotective molecule that is the endogenous inhibitor of vascular endothelial growth factor (VEGF) in the retina.
Laura Garcia-Garcia +15 more
doaj +1 more source
Animal Models and Experimental Medicine, EarlyView.The present study investigates the role of the NLRP3 inflammasome in the chronicity of ocular inflammation in uveitis using the experimental autoimmune uveitis (EAU) model. Whole eyes collected from EAU mice, 12 weeks post induction, were sectioned and subjected to immunohistochemistry. The confocal images from these sections were then assessed for the
Avik Shome +3 more
wiley +1 more source