Results 181 to 190 of about 2,749,048 (351)

High sampling resolution optical coherence tomography reveals potential concurrent reductions in ganglion cell‐inner plexiform and inner nuclear layer thickness but not in outer retinal thickness in glaucoma

Ophthalmic and Physiological Optics, Volume 43, Issue 1, Page 46-63, January 2023., 2023
Abstract Purpose To analyse optical coherence tomography (OCT)‐derived inner nuclear layer (INL) and outer retinal complex (ORC) measurements relative to ganglion cell‐inner plexiform layer (GCIPL) measurements in glaucoma. Methods Glaucoma participants (n = 271) were categorised by 10‐2 visual field defect type.
Janelle Tong, Jack Phu, David Alonso‐Caneiro, Sieu K. Khuu, Michael Kalloniatis   +4 more
wiley   +1 more source

Eye-Light on Age-Related Macular Degeneration: Targeting Nrf2-Pathway as a Novel Therapeutic Strategy for Retinal Pigment Epithelium [PDF]

, 2020
Michele Catanzaro, Cristina Lanni, Filippo Basagni, Michela Rosini, Stefano Govoni, Marialaura Amadio   +5 more
openalex   +1 more source

Artificial intelligence‐quantified schisis volume as a structural endpoint for gene therapy clinical trials in X‐linked retinoschisis

Acta Ophthalmologica, EarlyView.
Abstract Purpose To use artificial intelligence (AI) for quantifying schisis volume (ASV) in X‐linked retinoschisis (XLRS) for use as a structural endpoint in gene therapy clinical trials. Methods We used data from Singapore, the United Kingdom, the Netherlands, and the United States. The AI model was developed on 250 optical coherence tomography (OCT)
Tien‐En Tan, Peilun Dai, Jonathan Hensman, Peter Kiraly, Beau J. Fenner, Yong Liu, Rick S. M. Goh, Ian C. Han, Daniel S. W. Ting, Camiel J. F. Boon, M. Dominik Fischer   +10 more
wiley   +1 more source

A narrative literature review about alpha‐lipoic acid role in dry eye and ocular surface disease

Acta Ophthalmologica, EarlyView.
Abstract Ocular surface diseases (OSD) include various conditions that affect the eye's surface, causing discomfort and pain. One such condition, dry eye disease (DED), is a multifactorial disorder that significantly impacts patients' quality of life, with prevalence rates ranging from 5% to 50% and higher incidence in women.
Antonio J. Mateo Orobia, José Manuel Benítez del Castillo, Margarita Calonge, Christophe Baudouin, Marc Labetoulle   +4 more
wiley   +1 more source

Deep learning model for detecting cystoid fluid collections on optical coherence tomography in X‐linked retinoschisis patients

Acta Ophthalmologica, EarlyView.
Abstract Purpose To validate a deep learning (DL) framework for detecting and quantifying cystoid fluid collections (CFC) on spectral‐domain optical coherence tomography (SD‐OCT) in X‐linked retinoschisis (XLRS) patients. Methods A no‐new‐U‐Net model was trained using 112 OCT volumes from the RETOUCH challenge (70 for training and 42 for internal ...
Jonathan Hensman, Yasmine el Allali, Hind Almushattat, Coen de Vente, Clara I. Sánchez, Camiel J. F. Boon   +5 more
wiley   +1 more source

Epigenetic and pharmacological control of pigmentation via Bromodomain Protein 9 (BRD9)

Pigment Cell &Melanoma Research, Volume 36, Issue 1, Page 19-32, January 2023., 2023
Abstract Lineage‐specific differentiation programs are activated by epigenetic changes in chromatin structure. Melanin‐producing melanocytes maintain a gene expression program ensuring appropriate enzymatic conversion of metabolites into the pigment, melanin, and transfer to surrounding cells.
Tupa Basuroy, Megan Dreier, Caitlin Baum, Thomas Blomquist, Robert Trumbly, Fabian V. Filipp, Ivana L. de la Serna   +6 more
wiley   +1 more source

Molecular and cellular mechanisms underlying gyrate atrophy: Why is the retina primarily affected?

Acta Ophthalmologica, EarlyView.
Abstract Gyrate atrophy of the choroid and retina (GACR; OMIM #258870) is a rare early‐onset autosomal recessive disorder, caused by bi‐allelic pathogenic variants in the gene coding for ornithine aminotransferase (OAT) resulting in hyperornithinaemia.
Mark J. N. Buijs, Berith M. Balfoort, Marion M. Brands, Anneloor L. M. A. ten Asbroek, Camiel J. F. Boon, Roselie M. H. Diederen, Corrie Timmer, Margreet A. E. M. Wagenmakers, Hans R. Waterham, Ronald J. A. Wanders, Riekelt H. Houtkooper, Clara D. van Karnebeek, Arthur A. Bergen   +12 more
wiley   +1 more source

Genetically engineered multicistronic allele of Pmel yielding highly specific CreERT2‐mediated recombination in the melanocyte lineage

Pigment Cell &Melanoma Research, Volume 36, Issue 1, Page 71-77, January 2023., 2023
Abstract Genetic approaches that allow lineage tracing are essential to our future understanding of melanocytes and melanoma. To date, the approaches used to label melanocytes in mice have relied on random integration of transgenes driven by the promoters of the Tyrosinase and Dopachrome tautomerase genes, knock‐in to the Dopachrome tautomerase locus ...
Emma L. Wilkinson, Louise C. Brennan, Olivia J. Harrison, Zoe Crane‐Smith, Philippe Gautier, Margaret A. Keighren, Peter Budd, Karthic Swaminathan, Laura M. Machesky, Sarah L. Allinson, Ian J. Jackson, Richard L. Mort   +11 more
wiley   +1 more source

Aqueous humour concentrations of HB‐EGF, EGF and VEGF‐A and axial length in humans

Acta Ophthalmologica, EarlyView.
Abstract Purpose To investigate relationships between the intraocular concentrations of heparin‐binding epidermal growth factor (HB‐EGF), epidermal growth factor (EGF) and vascular endothelial growth factor A (VEGF‐A) in dependence on axial length in humans. Design Clinical interventional cohort study.
Wen‐Da Zhou, Li Dong, Yu‐Hang Yang, Yuan He, Xiao‐Zhen Wang, Han‐Qing Zhao, Rui‐Heng Zhang, Jost B. Jonas, Wen‐Bin Wei   +8 more
wiley   +1 more source

Trans-ocular Electric Current In Vivo Enhances AAV-Mediated Retinal Gene Transduction after Intravitreal Vector Administration

Molecular Therapy: Methods & Clinical Development, 2019
Adeno-associated virus (AAV) vector-mediated gene delivery is a promising approach for therapy, but implementation in the eye currently is hampered by the need for delivering the vector underneath the retina, using surgical application into the ...
Hongman Song, Ronald A. Bush, Yong Zeng, Haohua Qian, Zhijian Wu, Paul A. Sieving   +5 more
doaj