Results 81 to 90 of about 1,329,317 (278)

Single‐Cell Profiling Reveals a Protective WNT5A‐ATF3‐FOSB Signaling Axis in Hair Follicle Stem Cells During Androgenetic Alopecia

Advanced Science, EarlyView.
Androgenetic alopecia (AGA) is a common form of hair loss with limited treatment options. Silencing of WNT5A signaling, which is widely known as the trigger of the ncWNT signaling pathway, happens in hair follicle stem cells from balding areas. It leads to downregulation of ATF3 and its target FOSB.
Ruiyu Luo, Ke Fang, Changjiang Zhao, Jiachao Xiong, Yuan Zhu, Mingyang Lu, He Yan, Zihan Li, Baojin Wu, Hua Jiang, Yufei Li   +10 more
wiley   +1 more source

Dual‐line Genome‐scale CRISPR Screening Enables Robust Target Gene Discovery

Advanced Science, EarlyView.
A species‐optimized CRISPR platform integrates efficient piggyBac delivery, genome‐scale sgRNA libraries, and parallel screening in two independently engineered Bactrocera dorsalis Cas9 cell lines. Cross‐line consensus analysis filters line‐specific effects, enriches candidates with reproducible in vivo phenotypes, and reveals conserved, species ...
Ziniu Li, Jiao Qiao, Qiuyuan Zhang, Peipei Liu, Chenjun Zheng, Qi Zhou, Mengqi Ji, Zhihui Zhu, Xiaoxue Li, Hongyu Zhang   +9 more
wiley   +1 more source

Dermoscopy in the Evaluation of Nail Disorders.

, 2017
Nail dermoscopy was initially used only in the assessment of nail pigmentation, but now it is widely utilized for the evaluation of many nail disorders.
Aurora Alessandrini, Michela Starace, PIRACCINI, BIANCA MARIA, Bianca Maria Piraccini, ALESSANDRINI, AURORA MARIA, STARACE, MICHELA   +5 more
core   +1 more source

Differential predation alters pigmentation in threespine stickleback (Gasterosteus aculeatus) [PDF]

, 2018
Animal pigmentation plays a key role in many biological interactions, including courtship and predator avoidance. Sympatric benthic and limnetic ecotypes of threespine stickleback (Gasterosteus aculeatus) exhibit divergent pigment patterns.
Seth M. Rudman, Diana J. Rennison, Rentsch, Ana K., Gygax, Michelle, Rudman, Seth M., Rentsch, Ana K, Rennison, Diana J., Michelle Gygax, Ana K. Rentsch, Rennison, Diana J, Rudman, Seth M   +10 more
core   +2 more sources

Drought Stress Mediated Changes in Food Crops: Mechanisms and Remediation Strategies

Advanced Science, EarlyView.
This work presents a multi‐scale framework for flavonoid‐mediated drought tolerance in staple food crops, integrating ROS redox regulation, antioxidant defense, rhizosphere microbial interactions, and sustainable agronomic practices. This interdisciplinary model provides core insights to develop climate‐resilient cropping systems and enhance global ...
Xiaoyi Duan, Litao Wang, Tuuli‐Marjaana Koski, Lizhe An, Thomas Efferth, Yujie Fu   +5 more
wiley   +1 more source

Purple Urinary Bag Syndrome in a Patient with Acidic Urine: A Case Report

International Journal of Medical Students
Background: Purple urine bag syndrome (PUBS) is an uncommon condition characterized by a purple discoloration of urinary drainage systems. This phenomenon results from bacterial metabolism of tryptophan derivatives into indigo and indirubin pigments ...
Paolo Vigne, Rodrigo Aparicio
doaj  

Photobiomodulation for Skin Pigmentation Disorders: A Dual-Function Treatment. [PDF]

Photobiomodul Photomed Laser Surg, 2023
Hamblin MR.
europepmc   +1 more source

Stigmatization in patients with pigmentation disorders: the ISPOT study

International audienceThe ISPOT study, conducted across 48,000 participants in 34 countries, assesses stigmatization in pigmentation disorders using the PUSH-D questionnaire.
Liu, Wei, Lim, Henry, Alexis, Andrew, Kang, Hee Young, Demessant-Flavigny, Anne-Laure, Schalka, Sergio, Ly, Fatimata, Passeron, Thierry, Goh, Chee Leok, Puig, Susana, Ocampo Candiani, Jorge, Dreno, Brigitte, Kerob, Delphine, Ezzedine, Khaled, Le Floc’h, Caroline, Krutmann, Jean, Taieb, Charles, Morita, Akimichi   +17 more
core   +1 more source

Knowledge and therapeutic gaps : a public health problem in the rare coagulation disorders population

, 2011
Rare coagulation disorders (RCDs) present a considerable and multifaceted public health risk. Although inherited RCDs affect a minor segment of any local healthcare delivery system, their global impact is major and highlight the challenges of delivering ...
J. M. Soucie, Clotting Disorders Working Group, UDC Rare Bleeding, D. M. Dimichele, the European Network Rare Bleeding Disorders Database, A. D. Shapiro, D. J. Aschman, F. Peyvandi   +7 more
core   +1 more source

Autistic traits and autism spectrum disorders : the clinical validity of two measures presuming a continuum of social communication skills [PDF]

, 2010
Research indicates that autism is the extreme end of a continuously distributed trait. The Social Responsiveness Scale (SRS) and the Social and Communication Disorders Checklist (SCDC) aim to assess autistic traits.
Westerwald, Eva, Westerwald, E., Westerwald, E, Holtmann, M, Holtmann, M., Bölte, Sven, Freitag, C, Christine Freitag, Bolte, S, Holtmann, Martin, Eva Westerwald, Sven Bölte, Freitag, C., Fritz Poustka, Freitag, Christine M., Martin Holtmann, Poustka, F., Poustka, F, Poustka, Fritz   +18 more
core   +1 more source