Results 81 to 90 of about 621,146 (257)

Glutaminolysis Blockade‐Empowered Bimodal Nanodepot for Spatially Complementary Sono‐Thermal Ablation via PANoptosis and STING Activation Against Large Tumors

Advanced Science, EarlyView.
An injectable bimodal TCPD nanodepot disrupts glutaminolysis and TCA metabolism, sensitizing large tumors to spatially complementary sono‐thermal ablation for complete treatment coverage. This intervention induces mitochondrial and endoplasmic reticulum dysfunction, genotoxicity, and NAD+ depletion, converging to trigger PANoptosome assembly and ...
Yi‐Ming Liu, Juan Qin, Si‐Yuan Wu, Xue‐Zhen Zhu, Yun‐Fei Cai, Pei‐Yao Sun, Hao Yang, Xing‐Yue Wang, Shu Li, Duo Wang, Hai‐Dong Zhu   +10 more
wiley   +1 more source

Relación clínica-dermatoscópica-histológica de lesiones pigmentadas de piel sugestiva de melanoma

Acta Médica del Centro, 2022
Introduction: among neoplastic diseases, skin diseases have the highest incidence in adults; of this group, malignant melanoma is the one with the highest lethality.
Yordán Martín Pozo, Esther Carolina Apolinario Castillo, Damarys Pérez Fleites, Amelia Betancourt Pérez, Libardo Alba Castellanos, Ramón González Rodríguez   +5 more
doaj  

Single‐Nucleus Transcriptomic Atlas of Human Vellus Hair Pilosebaceous Units Reveals Age‐Associated Remodeling

Advanced Science, EarlyView.
Human vellus pilosebaceous units (PSUs) remain uncharted. This single‐nucleus atlas reveals coordinated remodeling of the aging PSU niche: reduced bulge stem cell representation with altered regenerative programs, increased representation of a stress‐responsive channel+ epithelial state, enhanced androgen‐responsive sebaceous programs, reduced ...
Ya'nan Li, Zhuoqiong Qiu, Xiaoyu Pan, Geyang Xu, Shanshan Peng, Ronghui Zhu, Qiuyang Luo, Xiaokai Fang, Xu Yao, Wei Li   +9 more
wiley   +1 more source

Villonodular synovitis of the lumbar spine: Case report of a rare pathology

Clinical Case Reports, 2020
Lumbar pigmented villonodular synovitis is rarely localized on the lumbar spine. Awareness of pigmented villonodular synovitis is important despite its rarity because it may mimic several other lesions of this location.
Ghassen Gader, Aymen Belaïd, Alia Zehani, Alifa Daghfous, Ihsèn Zammel, Mohamed Badri   +5 more
doaj   +1 more source

Analysis Of Skin Lesions With Pigmented Networks

, 1996
This paper deals with image processing for automatic analysis of pigmented skin lesions. A special emphasis is put on pigmented networks in epiluminescence microscopy (ELM) images.
Stefan Fischer, Philippe Schmid, Joël Guillod, Hopital Cantonal, Clinique De Dermatologie   +4 more
core  

A rhesus macaque model of α‐dystroglycanopathy caused by a POMT1 splice altering variant

Animal Models and Experimental Medicine, EarlyView.
Rhesus macaques homozygous for a naturally occurring spice altering variant in the POMT1 gene develop lissencephaly, microphthalmia, and muscular contracture. The presentation models severe presentation of the human Walker‐Warburg syndrome. Abstract Background Biallelic mutations in genes associated with α‐dystroglycan glycosylation manifest in a ...
Anya Nordlund, Brian LaMendola, Nathan P. Crilly, Seth Kittle, Betsy M. Ferguson, Anne D. Lewis, Jeff Wall, Samuel M. Peterson   +7 more
wiley   +1 more source

Developing a strain‐dependent susceptibility to hepatocellular carcinoma in a murine model based on histopathological evidence and genetic context

Animal Models and Experimental Medicine, EarlyView.
Using F1 (C57BL/6J/Smad4+/− X CC) mice, we found that partial loss of Smad4 promotes liver carcinogenesis in a strain‐dependent manner, highlighting the importance of genetic modifiers in tumor susceptibility. The use of Collaborative Cross mice provides a valuable platform for uncovering genotype‐specific cancer susceptibilities in preclinical ...
Osayd Zohud, Aysar Nashef, Imad Abu‐Elnaaj, Fuad A. Iraqi   +3 more
wiley   +1 more source

Description of Some Dermatoscopic Features of Acral Pigmented Lesions in Iranian Patients: A Preliminary Study [PDF]

Acta Medica Iranica, 2011
"nProper differentiation between acral malignant melanoma and benign pigmented lesions like melanocytic nevi is of great value. To avoid unnecessary biopsies, dermatoscopy has been introduced as a non-invasive modality and has improved the clinical ...
Azita Nikoo, Kambiz Kamyab, Sahar Azizahari, Homayoon Moslehi, Hayede Ghaninezhad, Reza Nemati Ahmadabad   +5 more
doaj   +2 more sources

Can a black pigmented lesion of the oral cavity predict future development of melanoma- Report of a case and review of literature

Journal of Family Medicine and Primary Care
Oral melanotic macules and primary oral malignant melanoma are distinct pigmented lesions that can present clinical challenges in diagnosis. While melanotic macules are generally benign, quite a few instances of progression to melanoma have been reported.
Shiladitya Sil, Rudra Pyne, Subhankar Ghosh, Nilanjana Saha   +3 more
doaj   +1 more source

Chrysin attenuates diabetes‐induced retinal injury by inhibiting microglial GBP3/NLRP3/GSDMD‐mediated pyroptosis

Animal Models and Experimental Medicine, EarlyView.
We investigated the therapeutic potential and mechanism of chrysin in experimental diabetic retinal disease. Using a streptozotocin (STZ)‐induced diabetic mouse model and high‐glucose‐stimulated BV2 microglia, we revealed chrysin‐responsive pyroptosis‐associated signatures and identified GBP3 as a regulated node.
Qun Liu, Song‐min Wang, Xuan Chen, Yi‐rao You, Chen‐jiao Guo, Chang‐qin Xie, Lu‐lu Wang, Qi Liu, Lan Zhang, Jun‐tao Yang   +9 more
wiley   +1 more source