Energy Sensing versus 2-Oxoglutarate Dependent ATPase Switch in the Control of Synechococcus PII Interaction with Its Targets NAGK and PipX. [PDF]
PLoS ONE, 2015 PII proteins constitute a superfamily of highly conserved signaling devices, common in all domains of life. Through binding of the metabolites ATP, ADP and 2-oxoglutarate (2-OG), they undergo conformational changes which allow them to regulate a variety ...
Jan Lüddecke, Karl Forchhammer
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PII-like signaling proteins: a new paradigm in orchestrating cellular homeostasis
Current Opinion in MicrobiologyMembers of the PII superfamily are versatile, multitasking signaling proteins ubiquitously found in all domains of life. They adeptly monitor and synchronize the cell's carbon, nitrogen, energy, redox, and diurnal states, primarily by binding interdependently to adenyl-nucleotides, including charged nucleotides (ATP, ADP, and AMP) and second messengers
Khaled A. Selim, Vikram Alva
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Frontiers in Plant Science, 2020 High levels of nitrogen are stored as arginine during the last stages of seed formation in maritime pine (Pinus pinaster Aiton). The protein sensor PII regulates the feedback inhibition of arginine biosynthesis through interaction with the key enzyme N ...
María Teresa Llebrés +7 more
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From PII signaling to metabolite sensing: a novel 2-oxoglutarate sensor that details PII-NAGK complex formation. [PDF]
PLoS ONE, 2013 The widespread PII signal transduction proteins are known for integrating signals of nitrogen and energy supply and regulating cellular behavior by interacting with a multitude of target proteins.
Jan Lüddecke, Karl Forchhammer
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A trimeric coiled-coil motif binds bacterial lipopolysaccharides with picomolar affinity
Frontiers in Cellular and Infection Microbiology, 2023 α-helical coiled-coils are ubiquitous protein structures in all living organisms. For decades, modified coiled-coils sequences have been used in biotechnology, vaccine development, and biochemical research to induce protein oligomerization, and form self-
Daniel Hatlem +6 more
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2-Oxoglutarate Levels Control Adenosine Nucleotide Binding by Herbaspirillum seropedicae PII Proteins [PDF]
FEBS Journal, 2015 Marco A S Oliveira +2 more
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Structure of the PII signal transduction protein of Neisseria meningitidis at 1.85 Ȃ resolution [PDF]
, 2006 Copyright @ 2006 International Union of CrystallographyThe PII signal transduction proteins GlnB and GlnK are implicated in the regulation of nitrogen assimilation in Escherichia coli and other enteric bacteria.
Berrow, NS +6 more
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Nitrogen regulation of protein–protein interactions and transcript levels of GlnK PII regulator and AmtB ammonium transporter homologs in Archaea [PDF]
, 2013 Gene homologs of GlnK PII regulators and AmtB-type ammonium transporters are often paired on prokaryotic genomes, suggesting these proteins share an ancient functional relationship.
Soppa, Jörg +6 more
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SVU - International Journal of Medical Sciences, 2022 Background: The radiologic pulmonary inflammatory index (PII) may be used as an early predictor of inflammation as laboratory assessments in COVID-19 cases.
Islam Galal * +7 more
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The Hexokinase Isoenzyme PII of Saccharomyces cerevisiae is a Protein Kinase [PDF]
Microbiology, 1989 The HXK2 gene product has an important role in controlling carbon catabolite repression in Saccharomyces cerevisiae. We have raised specific antibodies against the hexokinase PII protein and have demonstrated that it is a 58 kDa phosphoprotein with protein kinase activity.
P, Herrero, R, Fernández, F, Moreno
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