Results 81 to 90 of about 4,364,730 (221)

Biosynthetic relationships between three rat apolipoprotein B peptides

open access: yesJournal of Lipid Research, 1988
Rat liver is unique in secreting very low density lipoproteins (VLDL) with three size-isoforms of apolipoprotein B: PI and PIII correspond to B-100 and B-48, respectively, while PII is slightly smaller than PI and has no counterpart in other species ...
M A Reuben   +5 more
doaj   +1 more source

A State‐Gated Metallo‐DNAzyme Framework Programs Tumor Stress Vulnerability Through Metabolic Licensing

open access: yesAdvanced Science, EarlyView.
A tumor‐state‐gated metallo‐DNAzyme framework integrates miR‐21/APE1‐responsive GLUT1 silencing with Ca/Cu‐partitioned metal–nucleic acid assembly and cystine loading. The framework first weakens glucose‐dependent metabolic buffering and then amplifies copper‐ and disulfide‐associated stress, converting tumor metabolic adaptation into programmable ...
Xiaodong Ma   +8 more
wiley   +1 more source

The role of the T-loop of the signal transducing protein PII from Escherichia coli

open access: yes, 1996
The 3D structure of PII, the central protein that controls the level of transcription and the enzymatic activity of glutamine synthetase in enteric bacteria revealed that residues 37–55 form the ‘T’ loop, part of which protrudes from the core of the ...
Vasudevan, Subhash G.   +6 more
core   +1 more source

Life of PII -- A PII Obfuscation Transformer [PDF]

open access: yes, 2023
Protecting sensitive information is crucial in today's world of Large Language Models (LLMs) and data-driven services. One common method used to preserve privacy is by using data perturbation techniques to reduce overreaching utility of (sensitive ...
Deshmukh, Ajinkya   +2 more
core   +1 more source

Escherichia coli Glutamine Synthetase Adenylyltransferase (ATase, EC 2.7.7.49):  Kinetic Characterization of Regulation by PII, PII-UMP, Glutamine, and α-Ketoglutarate†

open access: yes, 2016
Glutamine synthetase adenylyltranferase (ATase, EC 2.7.7.49) catalyzes the adenylylation and deadenylylation of glutamine synthetase (GS), regulating GS activity.
Avraham E. Mayo (384895)   +2 more
core   +2 more sources

Asymmetric Structure‐Driven Functional Synergy: A Multistimuli‐Activated Janus Nanomotor for Self‐Amplifying NO Cascade Therapy

open access: yesAdvanced Science, EarlyView.
The Janus nanomotors leverage an “asymmetric structure‐driven functional synergy” strategy to orchestrate spatiotemporally coordinated catalytic functions, in situ self‐amplifying NO generation, and deep tumor penetration, thereby enabling controllable, sustained, and uniform NO generation within the tumor microenvironment.
Chengcheng Li   +6 more
wiley   +1 more source

Proteomic Insights into Starvation of Nitrogen-Replete Cells of Nostoc sp. PCC 7120 under β-N-Methylamino-L-Alanine (BMAA) Treatment

open access: yesToxins, 2020
All cyanobacteria produce a neurotoxic non-protein amino acid β-N-methylamino-L-alanine (BMAA). However, the biological function of BMAA in the regulation of cyanobacteria metabolism still remains undetermined.
Olga A. Koksharova   +4 more
doaj   +1 more source

Benefits and Harms of Herbal Medicines for Preventing and Treating Acute Respiratory Infections: An Overview of Systematic Reviews

open access: yesPhytotherapy Research, EarlyView.
Overview of systematic reviews evaluating the benefits and harms of herbal medicines for management of ARIs. ABSTRACT Hundreds of herbal medicines are currently marketed for the management of acute respiratory infections (ARIs). However, there is uncertainty about their benefits and harms, and clinical guidance remains unclear.
Fariba Aghajafari   +11 more
wiley   +1 more source

Regulation of the synthesis of glutamine synthetase by the PII protein in Klebsiella aerogenes. [PDF]

open access: yesProceedings of the National Academy of Sciences, 1980
Certain mutations at the glaB locus result in the failure to fully derepress glutamine synthetase [L-glutamate:ammonia ligase (ADP-forming), EC 6.3.1.2] and to convert it to the active nonadenylylated form in response to nitrogen limitation. In these mutants the PII regulatory protein is altered such that it cannot be converted by uridylyltransferase ...
F, Foor, Z, Reuveny, B, Magasanik
openaire   +2 more sources

Host range and molecular and ultrastructural analyses of Asparagus virus 1 pathotypes isolated from garden asparagus Asparagus officinalis L.

open access: yesFrontiers in Plant Science, 2023
Asparagus samples were examined from growing areas of Germany and selected European as well as North, Central and South American countries. Overall, 474 samples were analyzed for Asparagus virus 1 (AV1) using DAS-ELISA.
Edit Lantos   +5 more
doaj   +1 more source

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