Results 31 to 40 of about 113,317 (259)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Numerical investigation of scour behavior around complex piers under flood conditions

Frontiers in Built Environment
IntroductionLocal scour at bridge piers is a primary cause resulting bridge failure, a risk that is significantly exacerbated under extreme hydrodynamic events such as floods.MethodsThis study presents a numerical investigation of the scour behavior ...
Qiang Qin, Liangliang Shi, Yufei Li, Yujie Li, Haozhou Qin, Gang Ren, Zhiying Yang   +6 more
doaj   +1 more source

An efficient 2-way shear grillage model solution for bridge RC four-pile caps under wall loading [PDF]

, 2019
Reinforced concrete four-pile caps under wall loading occur in heavily loaded foundations in bridge construction. The failure mode of shear across the full width of the cap may occur in these deep structural elements.
Bloodworth, Alan G., Cao, Jing, Xu, Ming
core   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Geology of Tindfjallajökull volcano, Iceland [PDF]

, 2018
The geology of Tindfjallajökull volcano, southern Iceland, is presented as a 1:50,000 scale map. Field mapping was carried out with a focus on indicators of past environments.
Dave McGarvie, John A. Stevenson, Jonathan D. Moles, Jóhannesson H., Larsen G., Rittman A., Sarah C. Sherlock, Sigurdsson H., Sæmundsson K., Thórarinsson S., USA Defence Mapping Agency   +10 more
core   +3 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Field thermal response test of energy pile foundation with cap under intermittent and continuous heating

Shenzhen Daxue xuebao. Ligong ban, 2022
Energy pile foundation has dual functions of bearing capacity and the utilization of shallow geothermal energy， the depth of foundation and operation modes have a certain impact on the heat transfer performance of the energy pile.
CHEN Yu, KONG Gangqiang, MENG Yongdong, WANG Lehua, LIU Hongcheng   +4 more
doaj   +1 more source

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Seismic Interaction Characteristics of an Inclined Straight Alternating Pile Group-Soil in Liquefied Ground

Advances in Civil Engineering, 2019
In this paper, the pile-soil interaction of a low-rise pile cap foundation of an inclined straight alternating pile on two or three layers of a soil liquefaction site under seismic load is studied. By inputting the 0.5 g El Centro seismic wave in FLAC3D,
Desen Kong, Meixu Deng, Zhimin Zhao
doaj   +1 more source

Interpretation of the origin of massive replacive dolomite within atolls and submerged carbonate platforms : strontium isotopic signature ODP hole 866A, resolution Guyot, mid-Pacific mountains [PDF]

, 1996
Endo-upwelling is a geothermally driven convective process operating within the upper part of the volcanic foundation and overlying carbonate pile, in atolls and guyots.
Fagerstrom, J.A., Flood, P.G., Rougerie, Francis   +2 more
core   +1 more source