Results 41 to 50 of about 113,738 (305)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Strength of reinforced concrete pile caps [PDF]

Structures <html_ent glyph="@amp;" ascii="&amp;"/> Buildings, 2003
Discrepancies exist in the provisions for the design of reinforced concrete pile caps with regard to shear, between the two UK codes for structural concrete design, namely BS 8110 and BS 5400. These discrepancies have arisen in the historical development of the codes, and the implication is that one code is unsafe or the other is over-conservative ...
Bloodworth, A.G., Jackson, P.A., Lee, M.M.K.   +2 more
openaire   +2 more sources

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Seismic Interaction Characteristics of an Inclined Straight Alternating Pile Group-Soil in Liquefied Ground

Advances in Civil Engineering, 2019
In this paper, the pile-soil interaction of a low-rise pile cap foundation of an inclined straight alternating pile on two or three layers of a soil liquefaction site under seismic load is studied. By inputting the 0.5 g El Centro seismic wave in FLAC3D,
Desen Kong, Meixu Deng, Zhimin Zhao
doaj   +1 more source

Seismic Performance of Steel Pipe Pile to Cap Beam Moment Resisting Connections [PDF]

, 2013
INE/AUTC 13 ...
Fulmer, Steven J., Kowalsky, Mervyn J., Nau, James M.   +2 more
core  

PERENCANAAN ABUTMENT DAN PONDASI STUDI KASUS JEMBATAN KALIPANG JLS LOT 9 BALEKAMBANG-KEDUNGSALAM, KAB.MALANG [PDF]

, 2023
"The Kalipang Bridge is a bridge with a length of 60 meters built as part of the South Cross Line Lot 9 project, connecting Kedungsalam and Balekambang in Malang Regency, specifically at Sta 4+196.001.
Adji, Muhammad Rizky Nasrullah
core  

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Integrated Analysis of Optimization and Settlement Characteristics in Hybrid Pile Systems for Reused Foundations

Applied Sciences
Pile reuse is a common technique in bridge renovation projects. However, the interaction mechanisms between new and existing piles under a shared cap remain unclear, restricting the size setting and further optimization of new piles in existing pile ...
Jingsen Niu, Zheng Yang, Siyu Yin, Shengzhao Cheng   +3 more
doaj   +1 more source

Perencanaan Dermaga Pelabuhan Tanjung Bonang Rembang [PDF]

, 2014
Jetty Tanjung Bonang Rembang Port located on the coast of Sendangmulyo Village, Sluke Sub District, Rembang District, Central Java Province. This jetty construction is aiming to serve 10,000 DWT general cargo ship and to maximize distribute goods in the ...
P, P. N. (Priyo), Purwanto, P. (Purwanto), Wijaya, R. M. (Rizqi)   +2 more
core  

Trajectories of Physical Function in Canadian Children with Juvenile Idiopathic Arthritis

Arthritis Care &Research, Accepted Article.
Objectives We describe trajectories of physical function in children newly diagnosed with juvenile idiopathic arthritis (JIA) and identify trajectories with persisting functional impairments and associated baseline characteristics. Methods We included patients enrolled in the Canadian Alliance of Pediatric Rheumatology Investigators (CAPRI) Registry ...
Clare Cunningham, Meghan McPherson, Lillian Lim, Roberta A. Berard, Matthew Berkowitz, Jean‐Philippe Proulx‐Gauthier, Brian M. Feldman, Nicole Johnson, Dax G. Rumsey, Heinrike Schmeling, Lori B. Tucker, Thomas Loughin, Kristin M. Houghton, Jaime Guzman, The CAPRI Registry Investigators   +14 more
wiley   +1 more source