Results 31 to 40 of about 438,655 (299)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Numerical investigation of scour behavior around complex piers under flood conditions
Frontiers in Built EnvironmentIntroductionLocal scour at bridge piers is a primary cause resulting bridge failure, a risk that is significantly exacerbated under extreme hydrodynamic events such as floods.MethodsThis study presents a numerical investigation of the scour behavior ...
Qiang Qin +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Applied Sciences, 2022 The freezing/thawing stratification effect of seasonal factors or artificial disturbances in frozen soil regions has an important influence on the vertical vibration of the pile–soil–cap system. Taking into account the slippage between the pile and soil,
Qiang Li +5 more
doaj +1 more source
The behaviour of laterally loaded two-pile groups [PDF]
, 1992 The response of piles and two-pile groups to lateral loading has been studied by field tests and computationally. Due to the lack of field test data and because of uncertainty concerning the pile/soil system it has been suggested that further ...
Arta, M.R., Arta, Mahmood Reza
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Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Arthritis Care &Research, EarlyView.Objective To investigate the association between rheumatoid arthritis (RA) and coronary artery calcium (CAC) prevalence, incidence, and progression over four years in adults without prior cardiovascular disease. Methods A case‐cohort study within the Brazilian Longitudinal Study of Adult Health (ELSA‐Brasil) included 585 participants (86 patients with ...
Patrícia Fonseca Estrada +7 more
wiley +1 more source
Distribution of pile-soil stress in centrifugal modelling of composite foundation
Yantu gongcheng xuebao, 2020 Based on the centrifugal modelling of PCC pile-supported and geosynthetic-reinforced embankments and the three-dimensional finite element numerical model, the test methods for vertical earth pressure and stress distribution rules of pile-soil in ...
JIANG Yan-bin 1, 2, HE Ning 2, HE Bin 2, WANG Zhang-chun 2, ZHANG Zhong-liu 2, ZHU Rui 2
doaj +1 more source
Development of LRFD Procedures for Bridge Pile Foundations in Iowa Final Report, June 2010 [PDF]
, 2010 For well over 100 years, the Working Stress Design (WSD) approach has been the traditional basis for geotechnical design with regard to settlements or failure conditions.
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Advanced Engineering Materials, EarlyView.A numerical–experimental framework is developed for characterizing multi‐matrix fiber‐reinforced polymers (MM‐FRPs) combining epoxy and polyurethane matrices. Harmonic bending tests are integrated with finite element model updating (FEMU) to simultaneously identify elastic and viscoelastic material parameters.
Rodrigo M. Dartora +4 more
wiley +1 more source