Results 61 to 70 of about 151,970 (303)

Study on bearing capacity of permeable pipe pile by field optical fiber monitoring

Rock and Soil Mechanics, 2021
Permeable pipe piles are set in the soft soil foundation to accelerate the dissipation rate of excess pore water pressure induced by pile driving and then to accelerate the consolidation of soil around the pile.
WANG Jing, XIAO Tao, ZHU Hong-hu, MEI Guo-xiong, LIU Zheng-yuan, WEI Guang-qing   +5 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Determining the spatial and temporal extent of the influence of pile driving sound on harbour porpoises [PDF]

, 2017
Piling driving sound is known to impact harbour porpoise (Phocoena phocoena) distribution, but to date detailed knowledge on the combined spatial and temporal components of this impact over longer time periods remains lacking. From May to September 2016,
Debusschere, E., Degraer, S., Deneudt, K., Haelters, J., Norro, A., Reubens, J., Rumes, B.   +6 more
core  

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Avalanche Merging and Continuous Flow in a Sandpile Model

, 1999
A dynamical transition separating intermittent and continuous flow is observed in a sandpile model, with scaling functions relating the transport behaviors between both regimes.
C. Tang, H. Leschhorn, H. Nakanishi, K. Christensen, L. Kadanoff, M. Boguñá, M. Paczuski, Maya Paczuski, O. Narayan, P. Bak, P. Bak, P. Bak, P. Grassberger, S. S. Manna, T. Hwa, V. Frette, Álvaro Corral   +16 more
core   +1 more source

Bearing Capacity of Pile Foundations Embedded in Clays and Sands Layer Predicted Using PDA Test and Static Load Test [PDF]

, 2015
Static Load Test (SLT) is the realiable method to determine bearing capacity of pile foundations. However, SLT is relatively expensive and time consuming compared to Pile Driving Analyzer (PDA) test.
Budi, Gogot Setyo, KOSASI, MELISA, WIJAYA, DEWI HINDRA   +2 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source