Results 71 to 80 of about 853,717 (250)
Parameter calibration of hydraulic hammer pile driving based on wave equation
Yantu gongcheng xuebaoAccurate prediction of the pile penetration process is of great significance for offshore wind power and large-scale pile foundation engineering. Therefore, based on the one-dimensional wave equation and the finite difference method, a numerical analysis
YU Jian 1, 2, HE Guanbang 1, 2, LI Yexun 3, WANG Xian 3
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
The Dynamic Effect of Pile Installation in Sand on Nearby Piles
مجلة النهرين للعلوم الهندسية, 2017 Driven piles have often been used in many civil structures to provide structural loading support. However, the unavoidable vibrations induced by pile driving processes may cause varying degrees of damage to adjacent structures.
Talib K. Qassim AlSheakayree +2 more
doaj
Internal Force Analysis of Buried-boring Piles in the Yuanzishan Landslide
Applied Sciences, 2020 The Yuanzishan landslide is an unstable slope in Langzhong County, located in northeast Sichuan province, China. The Guangyuan-Nanchong expressway passes through the front edge of the unstable slope, and subgrade excavation has resulted in slope ...
Hao Wang +5 more
doaj +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Other title: Teen safe driving in Connecticut
, 2014 Annual; "Annual Report on Effectiveness of Connecticut's Teen Driving Laws.
core +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source