Results 111 to 120 of about 214,688 (304)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

The Impact of EC 7 in Axial Load Capacity Estimation of Pile Foundations [PDF]

open access: yes, 2013
The pile foundation is generally used in Albania. Until today their design is based onwhat it is called The Albanian Practice of Design. In these days, the implementation of theEurocode in the design, is considered very fundamental.
Alketa Ndoj   +3 more
core  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

Assessment of Optimum Reinforcement of Rebar for Joint of PHC Pile and Foundation Plate [PDF]

open access: bronze, 2010
Jong‐Bae Park   +4 more
openalex   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

open access: yesFEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini   +2 more
wiley   +1 more source

The Horizontal Bearing Characteristics and Microscopic Soil Deformation Mechanism of Pile-Bucket Composite Foundation in Sand

open access: yesApplied Sciences
The pile-bucket composite foundation represents an innovative foundation form that surpasses the horizontal bearing performance of both single bucket-shaped foundations and pile foundations.
Xin Zhang   +4 more
doaj   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

open access: yesFEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

Numerical Simulation Study on Lateral Displacement of Pile Foundation and Construction Process under Stacking Loads

open access: yesComplexity, 2018
Lateral displacement of pile foundation is crucial to the safety of an overall structure. In this study, a numerical simulation on the lateral displacement of pile foundation under stacking loads was conducted to determine its relation with different ...
Yan-yan Cai   +4 more
doaj   +1 more source

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