Results 101 to 110 of about 285,742 (250)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

A study on group efficiency of piles in sand

Tạp chí Khoa học Đại học Mở Thành phố Hồ Chí Minh - Kỹ thuật và Công nghệ, 2016
Bearing capacity of pile group in cohesionless soil is an interesting topic with studies about coefficient of efficiency, about critical depth where skin friction seems constant with respect to depth of embedment/installation etc ...
Dương Hồng Thẩm, Nguyễn Thanh Hà, Võ Hoàng Trí   +2 more
doaj  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

An Experimental Study on Pile Spacing Effects under Lateral Loading in Sand

The Scientific World Journal, 2013
Grouped and single pile behavior differs owing to the impacts of the pile-to-pile interaction. Ultimate lateral resistance and lateral subgrade modulus within a pile group are known as the key parameters in the soil-pile interaction phenomenon.
Mahdy Khari, Khairul Anuar Kassim, Azlan Adnan   +2 more
doaj   +1 more source

Combinatorics of patience sorting piles [PDF]

, 2005
Despite having been introduced in 1962 by C.L. Mallows, the combinatorial algorithm Patience Sorting is only now beginning to receive significant attention due to such recent deep results as the Baik-Deift-Johansson Theorem that connect it to fields ...
Burstein, Alexander, Lankham, Isaiah
core   +3 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Optimization of bearing capacity and unsymmetrical settlement of vertical pile group using genetic algorithm [PDF]

Journal of Structural and Construction Engineering, 2016
Capacity of pile group is the summation of the individual piles capacity with influence of spacing between the piles. Pile groups usually have the same length, so if the spacing between piles is too close, the zones of stress around the pile will overlap
Saeed Ghaffarpour Jahromi, Abdollah Hoseini   +1 more
doaj  

A contact problem aplication for the local behaviour of soil pile interaction [PDF]

, 2017
In geotechnical engineering, the main parameter for the performance of structures such as reinforced walls or deep foundations is often the shaft bearing capacity.
Baeßler, Matthias, Bronsert, Jeffrey, Dutto, Paola, Kullolli, Borana, Stutz, Henning   +4 more
core  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Effects of disc overhang diameter on the uplift bearing capacity of new-type concrete expanded-plate pile groups

Scientific Reports
The disc overhang diameter can significantly affect the uplift bearing capacity of new concrete expanded-plate pile groups, affecting their design and practical applications.
Yongmei Qian, Mingyue Che, Da Teng, Chao Lin, Zunpeng Liu, Kai Zhang   +5 more
doaj   +1 more source