Results 101 to 110 of about 9,169,343 (304)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

Antea Group Archeologie 2020/72

open access: yes, 2020
Auteurs: R. Fens & I. Fleuren rapportvolgnummer: 2020/72 Antea Group projectnummer 271507 ARCHIS-nr 4856764100 Het plangebied ligt langs de voormalige Zuiderzeekust. De vestingstad Muiden, een van oorsprong middeleeuwse stad, bevindt zich aan de monding
Koopmanschap, H (Antea Group)   +16 more
core   +1 more source

Shear capacity of reinforced concrete pile caps

open access: yes
Reinforced concrete pile caps may be considered to act either as deep beams, or analogous to a truss. When designed as a deep beam, there is currently a contradiction in the shear design between two UK structural engineering codes of practice – the ...
Cao, J., Xu, M., Bloodworth, A.G.
core   +1 more source

A study on group efficiency of piles in sand

open access: yesTạp chí Khoa học Đại học Mở Thành phố Hồ Chí Minh - Kỹ thuật và Công nghệ, 2016
Bearing capacity of pile group in cohesionless soil is an interesting topic with studies about coefficient of efficiency, about critical depth where skin friction seems constant with respect to depth of embedment/installation etc ...
Dương Hồng Thẩm   +2 more
doaj  

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

open access: yesMolecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim   +11 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

Manly [cartographic material] : 7 villa sites near tram line, ocean views 12/6 per foot /

open access: yes, 1890
Sales plan for land in the suburb of Queenscliff in Sydney bounded by Pittwater Road, Queenscliff Road and Pavillion Street.; "Torrens title."; Also available in an electronic version via the internet at: http://nla.gov.au/nla.map ...
Pile, G.
core  

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

open access: yesFEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour   +2 more
wiley   +1 more source

Fairview Estate, Manly [cartographic material] : for sale on the ground /

open access: yes, 1885
Sales plan for land in the suburb of Manly in Sydney bounded by The Corso, Esplanade, The Crescent, Fairlight Street and George Street.; "Terms, 10% deposit, balance in 12 quarterly payments, interest 5%."; Also available in an electronic version via the
Mills & Pile.
core  

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

open access: yesFEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell   +8 more
wiley   +1 more source

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