Results 71 to 80 of about 303,526 (295)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Influence of Pile Spacing on the Compressive Bearing Performance of CEP Groups

Buildings
Pile spacing is an important factor affecting the bearing capacity of concrete expansion pile (CEP) groups. In this study, a pile group was simulated and analyzed using ANSYS software R19.0.
Yongmei Qian, Qingzhi Cao, Yang Yang, Da Teng, Tingting Zhou   +4 more
doaj   +1 more source

Dynamic response analysis of a large-diameter steel tube pile group subjected to hammering loads

Yantu gongcheng xuebao, 2017
A large-diameter steel tube pile is used in a machinery factory in Shanghai to test the new produced diesel pile hammer. However, with the increase of the diesel hammer weight, it fails to meet the test requirements and a pile group is recommended to ...
FENG Shi-jin 1, 2, WANG Lei 1
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Multiple-Planet Scattering and the Origin of Hot Jupiters

, 2011
Exoplanets show a pile-up of Jupiter-size planets in orbits with a 3-day period. A fraction of these hot Jupiters have retrograde orbits with respect to the parent star's rotation.
Beutler, C. Beaugé, Chatterjee, D. Nesvorný, Darwin, Duncan, Fabrycky, Hansen, Hut, Jackson, Juric, Lai, Lai, Levison, Lidov, Marchal, Mardling, Matsumura, Mayor, McArthur, Moeckel, Morbidelli, Nagasawa, Nagasawa, Schlaufman, Thommes, Throop, Winn, Wu, Wu   +29 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Revolving rivers in sandpiles: from continuous to intermittent flows

, 2007
In a previous paper [Phys. Rev. Lett. 91, 014501 (2003)], the mechanism of "revolving rivers" for sandpile formation is reported: as a steady stream of dry sand is poured onto a horizontal surface, a pile forms which has a river of sand on one side owing
E. Altshuler, E. Martínez, J. Schmittbuhl, K. J. Måløy, O. Sotolongo-Costa, R. Toussaint, T. Takahashi   +6 more
core   +4 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source