Results 101 to 110 of about 34,054 (232)

Valuing condition specific health states using simulation contact lenses [PDF]

OBJECTIVE: This paper reports on a study that used contact lenses to simulate the effects of a visual impairment caused by Age Related Macular Degeneration (ARMD).
Brazier, J., Carlton, J., Czoski-Murray, C., Kang, H.K., Papo, N.L., Young, T.A.   +5 more
core  

Innovative Drug Delivery Systems for the Treatment of Glaucoma

MedComm – Biomaterials and Applications, Volume 5, Issue 2, June 2026.
This review aims to provide a comprehensive overview of current topical drug delivery strategies for ocular hypotensive agents in glaucoma therapy. Additionally, it discusses the potential impact of emerging nanotechnological and biomaterial‐based systems in shaping the future of ophthalmic drug delivery, with an emphasis on enhancing efficacy, safety,
Jing Chu, Junzhi Li, Zhenlin Chen, Jinyu Zhang, Siqi Feng, Jiaying Huang, Yawen Chu, Xue Zhou, Wei Wang, Shangsi Chen   +9 more
wiley   +1 more source

Construction of a pilocarpine-induced temporal lobe epilepsy model in mice based on severe seizure behavior

Zhongguo Linchuang Yixue
Objective To explore the approach to establish a temporal lobe epilepsy model via intraperitoneal pilocarpine injection in C57BL/6J mice, and to summarize behavioral indicators predicting successful modeling during the acute phase of epileptic seizures ...
Fangchao TONG, Yiying CAI, Yuanfang LI, Qiang WANG, Jing DING, Xin WANG   +5 more
doaj   +1 more source

Neuronal damage and memory deficits after seizures are reversed by ascorbic acid? O dano neuronal e o déficit de memória após convulsões são revertidos pelo ácido ascórbico?

Arquivos de Neuro-Psiquiatria, 2010
The objective of the present study was to evaluate the neuroprotective effects of ascorbic acid (AA) in rats, against the neuronal damage and memory deficit caused by seizures.
Adriana da Rocha Tomé, Chistiane Mendes Feitosa, Rivelilson Mendes de Freitas   +2 more
doaj   +1 more source

Assessment of the Preventive Effect of Pilocarpine on Radiotherapy-Induced Xerostomia in Patients with Head and Neck Cancers [PDF]

, 2015
Introduction Xerostomia is one of side-effects of radiotherapy for head and neck cancers. No definitive method has been proposed for the treatment of this condition. However, pilocarpine is considered effective for the management of chronic xerostomia.
Akhavan Karbasi, Mohammad Hasan., Akhavan, Seyed Ali., Donyadide, Nastaran., Shamshiry, Pejman., Zarghani, Hassan.   +4 more
core   +1 more source

Rapid astrocyte and microglial activation following pilocarpine-induced seizures in rats. [PDF]

, 2008
Astrocyte and microglial activation occurs following seizures and plays a role in epileptogenesis. However, the precise temporal and spatial response to seizures has not been fully examined. The pilocarpine model of temporal lobe epilepsy was selected to
Austin, Belluardo, Bendotti, Bianchi, Binder, Bolwig, Bordey, Borges, Borges, Briellmann, Buckmaster, Cajal, Drage, Garzillo, Griffin, Griffin, Hansen, Huttmann, Kang, Li, McCloskey, Mello, Niquet, Palmer, Parent, Peters, Petito, Ribak, Rothermundt, Selinfreund, Shapiro, Shapiro, Shapiro, Shapiro, Shapiro, Sheng, Ueda, Vessal, Yan   +38 more
core   +1 more source

Microglia Mitochondria Support Neuronal Maturation via Metabolic and Transcriptional Reprogramming in Human 3D In Vitro Brain Model

Advanced Science, Volume 13, Issue 25, 4 May 2026.
xx xx. ABSTRACT Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by disrupted neuronal circuit maturation. Emerging evidence implicates microglial function and mitochondrial regulation as contributors to ASD‐associated biology, yet the mechanisms linking these processes to neuronal development remain poorly defined ...
Sydney P. Sterben, Charitha C. Anamala, Sahan B. S. Kansakar, Vaishnavi Koduri, Volha Liaudanskaya   +4 more
wiley   +1 more source

Effect of pilocarpine on the formalin-induced orofacial pain in rats [PDF]

Veterinary Research Forum, 2012
In this study, the effects of subcutaneous (SC) injection of pilocarpine (a cholinomimetic agent) and atropine (a muscarinic receptors antagonist) were investigated on a tonic model of orofacial pain in rats.
Esmaeal Tamaddonfard, Amir Erfanparast, Emad Khalilzadeh   +2 more
doaj  

Epigenetic suppression of hippocampal calbindin-D28k by ΔFosB drives seizure-related cognitive deficits. [PDF]

, 2017
The calcium-binding protein calbindin-D28k is critical for hippocampal function and cognition, but its expression is markedly decreased in various neurological disorders associated with epileptiform activity and seizures.
Chin, Jeannie, Corbett, Brian F., LaFrancois, John J., Mohila, Carrie A., Muralidharan, Kavitha, Nestler, Eric J., Park, Jin W., Petrof, Iraklis, Pyfer, Mark S., Rissman, Robert A., Scharfman, Helen E., Yoshor, Daniel, You, Jason C., Zhang, Xiaohong, Zheng, Yi   +14 more
core   +1 more source

Inroads into epilepsy through high‐frequency oscillations: Achievements and benchmark areas for improvement

Epilepsia, Volume 67, Issue 5, Page 2099-2116, May 2026.
Abstract High‐frequency oscillations (HFOs) were discovered more than 20 years ago, and since then they have been studied intensively in the context of epilepsy. HFOs encompass a broad spectrum of oscillations, typically ranging from 80 Hz to several kHz, that include both normal and pathological oscillations, documented in people with epilepsy and ...
Christos Panagiotis Lisgaras, Birgit Frauscher, Jean Gotman, Julia Jacobs, Philippe Kahane, Richard J. Staba, Maeike Zijlmans   +6 more
wiley   +1 more source