Results 81 to 90 of about 17,433 (189)

Microenvironment‐Responsive Drug Delivery Systems for Ocular Surface Diseases: Mechanisms, Applications, and Translational Challenges

Small Science, Volume 6, Issue 8, August 2026.
Microenvironment‐responsive drug delivery systems overcome ocular physiological barriers by responding to temperature, pH, ions, reactive oxygen species, and enzymes. This review bridges material design, performance evaluation, and clinical translation, offering actionable insights for treating dry eye disease, infectious keratitis, and corneal ...
Jiamin Liu, Liangbo Chen, Yao Fu, Siyi Zhang   +3 more
wiley   +1 more source

Pilocarpine [PDF]

Reactions Weekly, 2020
  +4 more sources

Efficacy of combined administration of Baekhogainsam-Tang and low-dose pilocarpine on frequent intractable xerostomia: Study protocol for a randomized controlled trial.

PLoS ONE
BackgroundIntractable xerostomia is defined as the subjective perception of dry mouth and persistent salivary gland hypofunction. Pilocarpine is an approved salivary sialagogue that is frequently prescribed for the treatment of intractable xerostomia ...
Su Il Kim, Young Chan Lee, Ji Won Kim, Bo-Hyung Kim, Junhee Lee, Young-Gyu Eun   +5 more
doaj   +1 more source

Efficacy and Safety of Pilocarpine Eye Drops Combinations for Treating Presbyopia in a Thai Population: A Randomized Crossover Trial

Siriraj Medical Journal
Objective: This study aimed to assess and compare the effectiveness and side effects of various concentrations of pilocarpine eye drops (1.5%, 1.25%, and 1%), with and without 0.1% brimonidine, in treating presbyopia, specifically in a Thai population.
Thammanoon Surachatkumtonekul, Pinpilai Jutasompakorn, Anchalika Klinniyom, Wasawat Sermsripong, Kiatthida Hokierti, Prapasson Sangsre, Ketchanya Rungsiri   +6 more
doaj  

Development and characterization of niosomes loaded mucoadhesive biodegradable ocular inserts for extended release of pilocarpine HCl

Future Journal of Pharmaceutical Sciences
Background Pilocarpine HCl is a non-selective muscarinic receptor agonist that is prescribed for the treatment of glaucoma. The use of pilocarpine conventional eye drops is associated with several side effects, such as loss of visual acuity, and the need
Tamara Ahmad Alotaibi, Affiong Iyire, Shereen Assaf, Eman Zmaily Dahmash   +3 more
doaj   +1 more source

Dose-Dependent Induction of Differential Seizure Phenotypes by Pilocarpine in Rats: Considerations for Translational Potential

Medicina
Background and Objectives: Pilocarpine is used in experimental studies for testing antiepileptic drugs, but further characterization of this model is essential for its usage in testing novel drugs. The aim of our study was to study the behavioral and EEG
Dolika Vasović, Olivera Stanojlović, Dragan Hrnčić, Nikola Šutulović, Milena Vesković, Aleksandar J. Ristić, Nebojša Radunović, Dušan Mladenović   +7 more
doaj   +1 more source

Temporal lobe epilepsy and changes in the M current

Revista Mexicana de Neurociencia
Objective: Acquired alterations of ion channel function occur after status epilepticus (SE). Kv7 channels mediate a sustained outward current (IM) that exerts pivotal control over neuronal excitability.
Hugo Solís, Estela López-Hernández
doaj  

From molecular design to antiepileptic evaluation: sulfonamide-pyrazole derivatives as promising neuroactive agents. [PDF]

RSC Adv
Elgohary MK, Alkabbani MA, Ahmed Ibrahim AM, Elsonbaty A, Abubakr A, Mohamed MH, Almehizia AA, Naglah AM, Fares M, Abdel-Aziz HA.   +9 more
europepmc   +1 more source

Efficacy and safety of pilocarpine as a secretagogue versus artificial tears in the management of dry eye disease. [PDF]

Med Hypothesis Discov Innov Ophthalmol
Elsayed Saad EM, Elbadry Mohammed Mohammed H, Tharwat E, Ali Ayoub AA, Salama Selim OH, Elsayed Abdelhafeez SM, Mohammed Yusef N, Farouk Soltan TA, Abdelhamid Elfar AA, Abdelhalim Ali Ali M.   +9 more
europepmc   +1 more source

Enhancing presbyopia treatment: A comparative study of 1% Pilocarpine monotherapy versus combination with 0.09% Bromfenac. [PDF]

Indian J Ophthalmol
Jain A, Sen S, Imchen MT, Gangwar A, Yadav M, Dubey P.   +5 more
europepmc   +1 more source