Results 71 to 80 of about 17,433 (189)

The Blood-Brain Barrier Breakdown During Acute Phase of the Pilocarpine Model of Epilepsy Is Dynamic and Time-Dependent

Frontiers in Neurology, 2019
The maintenance of blood-brain barrier (BBB) integrity is essential for providing a suitable environment for nervous tissue function. BBB disruption is involved in many central nervous system diseases, including epilepsy.
Natália Ferreira Mendes, Aline Priscila Pansani, Elis Regina Ferreira Carmanhães, Poliana Tange, Juliana Vieira Meireles, Mayara Ochikubo, Jair Ribeiro Chagas, Alexandre Valotta da Silva, Glaucia Monteiro de Castro, Luciana Le Sueur-Maluf   +9 more
doaj   +1 more source

Integrated Phytochemical Characterisation, Pharmacological Evaluation and Computational Investigation of Acampe papillosa Stem Extract

Analytical Science Advances, Volume 7, Issue 2, December 2026.
The pharmacological potential of the methanolic stem extract of Acampe papillosa is evaluated using in vivo and in silico approaches. The extract demonstrates significant anxiolytic, sedative, anti‐inflammatory, and antipyretic activities in experimental models, while molecular docking supports the observed biological effects through favorable ...
Qurratul Ain Sadia, Sadia Tamanna Tamim, Faruq Mohammed Tashriq, Nasir Uddin, Fatematus Zhohara Alam Hima, Ulfat Sobha Surat, Mily Khastagir, Muhammad Abdul Jalil, Md. Hossain Rasel, Arman Ullah Rafi, S. M. Moazzem Hossen   +10 more
wiley   +1 more source

Neuronal damage and memory deficits after seizures are reversed by ascorbic acid? O dano neuronal e o déficit de memória após convulsões são revertidos pelo ácido ascórbico?

Arquivos de Neuro-Psiquiatria, 2010
The objective of the present study was to evaluate the neuroprotective effects of ascorbic acid (AA) in rats, against the neuronal damage and memory deficit caused by seizures.
Adriana da Rocha Tomé, Chistiane Mendes Feitosa, Rivelilson Mendes de Freitas   +2 more
doaj   +1 more source

Sleep Deprivation and Neuronal Hyperexcitation Share Transcriptomic Signatures

Neuropsychopharmacology Reports, Volume 46, Issue 3, September 2026.
This study demonstrated that sleep deprivation induces transcriptomic changes in mice and rats similar to those observed in various models of neuronal hyperexcitation. These findings suggest a potential link between sleep deprivation and neuropsychiatric disorders.
Markos Michail Chatzigiannis, Hideo Hagihara, Tsuyoshi Miyakawa   +2 more
wiley   +1 more source

On the action of pilocarpine [PDF]

The Journal of Physiology, 1927
T B, Heaton, M H, Mackeith
openaire   +2 more sources

Advancements in Enzymatic Biofuel Cells for Wearable Electrochemical Biosensors: Powering Point‐of‐Care Health Monitoring

Advanced Sensor Research, Volume 5, Issue 8, August 2026.
Advances in enzymatic biofuel cells are highlighted through innovative electrode architectures, enzyme immobilization strategies, and hybrid integration with triboelectric, piezoelectric, and thermoelectric energy harvesters. These emerging approaches improve power output, operational stability, and biocompatibility, advancing self‐powered wearable and
Rashid Khan, Mohammad Abrar Uddin, Yi Jae Lee, Taeil Kim   +3 more
wiley   +1 more source

Efficacy of Pilocarpine and Bromhexine in Improving Radiotherapy-induced Xerostomia

Journal of Dental Research, Dental Clinics, Dental Prospects, 2013
Background and aims. Xerostomia is one of the most common complications of head and neck radiotherapy. The aim of this study was to evaluate and compare the efficacy of pilocarpine and bromhexine in improving radiotherapy-induced xerostomia and its ...
Farid Abbasi, Sareh Farhadi, Mostafa Esmaili   +2 more
doaj   +1 more source

Lipid‐based Nano‐delivery systems as a promising strategy for the treatment of epilepsy: Current status and challenges

Epilepsia Open, Volume 11, Issue 4, Page 1095-1110, August 2026.
Abstract Objective Epilepsy is a prevalent chronic neurological disorder characterized by abnormal neuronal electrical activity. The primary treatment modality for individuals with epilepsy (PWE) is antiseizure medication (ASM). The multiple potential factors contributing to treatment resistance in epilepsy may be attributed to the inability of ASMs to
Priya Kannan Varshini, Arunachalam Divya, Kumar Sowndharya, Parthiban Jeevitha, Selvam Manoj, Ashiq Rahman, Athil Ahamed, Ravichandiran Abirahul, Paranthaman Subash, Sulekha Khute   +9 more
wiley   +1 more source

Astrocytes in Genetic Epilepsies: Supporting Actor or Key Player?

Journal of Neuroscience Research, Volume 104, Issue 8, August 2026.
Astrocytes contribute to the pathophysiology of acquired epilepsy. However, less is known about their contribution to genetic epilepsy syndromes which often exhibit frequent comorbidity with neurodevelopmental and psychiatric disorders. Epileptic seizures are also frequently present in neurodevelopmental disorders.
Jenny Lange, Erica Zhao, Ellie O'Connell, Olivia Gillham, Amy McTague   +4 more
wiley   +1 more source

Oral Spermidine Supplementation Preserves Submandibular Gland Function After Radiotherapy: Mechanistic Insights and Use in a Phase II Randomized Clinical Trial

MedComm, Volume 7, Issue 8, August 2026.
Radiotherapy‐induced xerostomia severely impairs quality of life. Integrated multiomics, organoids, murine models, and a randomized Phase II trial identified spermidine as a key radiation‐responsive metabolite. Oral spermidine preserved salivary gland function, maintained acinar cell integrity through Golgi‐mediated posttranslational modifications ...
Yu Min, Kun Gao, Yingtong Liu, Lei Dai, Xingchen Peng   +4 more
wiley   +1 more source