Results 71 to 80 of about 17,396 (187)

Construction of a pilocarpine-induced temporal lobe epilepsy model in mice based on severe seizure behavior

Zhongguo Linchuang Yixue
Objective To explore the approach to establish a temporal lobe epilepsy model via intraperitoneal pilocarpine injection in C57BL/6J mice, and to summarize behavioral indicators predicting successful modeling during the acute phase of epileptic seizures ...
Fangchao TONG, Yiying CAI, Yuanfang LI, Qiang WANG, Jing DING, Xin WANG   +5 more
doaj   +1 more source

Effect of pilocarpine on the formalin-induced orofacial pain in rats [PDF]

Veterinary Research Forum, 2012
In this study, the effects of subcutaneous (SC) injection of pilocarpine (a cholinomimetic agent) and atropine (a muscarinic receptors antagonist) were investigated on a tonic model of orofacial pain in rats.
Esmaeal Tamaddonfard, Amir Erfanparast, Emad Khalilzadeh   +2 more
doaj  

Neuronal damage and memory deficits after seizures are reversed by ascorbic acid? O dano neuronal e o déficit de memória após convulsões são revertidos pelo ácido ascórbico?

Arquivos de Neuro-Psiquiatria, 2010
The objective of the present study was to evaluate the neuroprotective effects of ascorbic acid (AA) in rats, against the neuronal damage and memory deficit caused by seizures.
Adriana da Rocha Tomé, Chistiane Mendes Feitosa, Rivelilson Mendes de Freitas   +2 more
doaj   +1 more source

Prevalence of Cystic Fibrosis and Pattern of Lung Function Impairment in Adults Presenting With Bronchiectasis at a Tertiary Care Hospital in Resource Poor Country Bangladesh: A Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 7, July 2026.
ABSTRACT Background and Aims Bronchiectasis is a common but neglected respiratory condition, particularly in resource‐poor countries such as Bangladesh. Cystic fibrosis (CF), a recognized cause of bronchiectasis in children, especially among Caucasians, is increasingly reported in adults of Asian descent.
Shuvo Majumder, Pujaneeta Biswas, Manal Mizanur Rahman, Md Sohidul Islam, Md. Mizanur Rahman, Susanta Kumar Paul, Md. Hamza, Mohammed Humayun Kabir, Samprity Islam, Fazle Rabbi Chowdhury, Rajashish Chakrabortty, Shamim Ahmed, Mohammed Atiqur Rahman   +12 more
wiley   +1 more source

The Blood-Brain Barrier Breakdown During Acute Phase of the Pilocarpine Model of Epilepsy Is Dynamic and Time-Dependent

Frontiers in Neurology, 2019
The maintenance of blood-brain barrier (BBB) integrity is essential for providing a suitable environment for nervous tissue function. BBB disruption is involved in many central nervous system diseases, including epilepsy.
Natália Ferreira Mendes, Aline Priscila Pansani, Elis Regina Ferreira Carmanhães, Poliana Tange, Juliana Vieira Meireles, Mayara Ochikubo, Jair Ribeiro Chagas, Alexandre Valotta da Silva, Glaucia Monteiro de Castro, Luciana Le Sueur-Maluf   +9 more
doaj   +1 more source

Epilepsy: Epidemiology, Molecular Pathogenesis, and Clinical Management

MedComm, Volume 7, Issue 7, July 2026.
Epilepsy is a heterogeneous and chronically evolving brain network disorder. This review integrates epidemiological burden, psychiatric comorbidities, and cyclic seizure patterns with multiscale pathogenic mechanisms, including ion‐channel dysfunction, synaptic transmission defects, neuroinflammation, metabolic and mitochondrial dysfunction, and ...
Jian Liu, Xinyan Wu, Ting Yin, Feining Huang, Manqi Kong, Yu Yang, Zinan Liu, Jiabin Yu, Tianpeng Zhang   +8 more
wiley   +1 more source

Therapeutic potential of small molecules that block receptor‐induced Kv7/M‐current suppression in neuroprotection, seizures, and pain

British Journal of Pharmacology, Volume 183, Issue 13, Page 3780-3795, July 2026.
Receptor‐induced Kv7/M‐current suppression increases neuronal activity and contributes to pathology of several conditions. A new class of Kv7 modulators identified in this study attenuates M‐current suppression and shows therapeutic effects. Abstract Background and Purpose Neuronal Kv7 channels generate low voltage–gated potassium currents known as the
Young Woo Kim, Pavan Kumar Behara, Lamees Alhassen, Cindy Wong, Olivier Civelli, Naoto Hoshi   +5 more
wiley   +1 more source

On the action of pilocarpine [PDF]

The Journal of Physiology, 1927
T B, Heaton, M H, Mackeith
openaire   +2 more sources

Ocular Manifestations in Dogs With Facial Nerve Dysfunction

Veterinary Ophthalmology, Volume 29, Issue 4, July 2026.
ABSTRACT Objective To characterize the spectrum and frequency of ocular abnormalities associated with facial nerve dysfunction (FND) in dogs and to assess clinical outcomes, with specific comparison between brachycephalic (BC) and non‐brachycephalic (NBC) breeds: Methods Medical records of dogs with FND evaluated between 2009 and 2023 at the ...
L. Gaztelu, M. Leiva, T. Peña, J. Ríos
wiley   +1 more source

Efficacy of combined administration of Baekhogainsam-Tang and low-dose pilocarpine on frequent intractable xerostomia: Study protocol for a randomized controlled trial.

PLoS ONE
BackgroundIntractable xerostomia is defined as the subjective perception of dry mouth and persistent salivary gland hypofunction. Pilocarpine is an approved salivary sialagogue that is frequently prescribed for the treatment of intractable xerostomia ...
Su Il Kim, Young Chan Lee, Ji Won Kim, Bo-Hyung Kim, Junhee Lee, Young-Gyu Eun   +5 more
doaj   +1 more source