Results 51 to 60 of about 23,504 (181)

Pharmacological effects of gastrodin: Insight into neurological diseases and mechanism in ferroptosis and pyroptosis

open access: yesIbrain, Volume 11, Issue 1, Page 74-83, Spring 2025.
Pharmacological effects of gastrodin include prevention and treatment of cognitive decline and reperfusion injuries, anticonvulsion, antiepilepsy, antidepressants, and analgesia, which are related to antiferroptosis and antipyroptosis. Abstract Gastrodin, as an effective monomer of gastrodia elata, plays a significant role in anti‐inflammatory ...
Xue Zheng, Jing Li, Zhao‐Qiong Zhu
wiley   +1 more source

Pilocarpine

open access: yes, 2007
Pilocarpine is a direct-acting parasympathomimetic agent exerting a broad spectrum of pharmacological actions mediated through muscarinic acetylcholine receptors.
Hancock, John, John Hancock
core   +1 more source

A Systematic Review and Meta-Analysis on the Efficacy and Safety of Topical Pilocarpine 1.25% in Presbyopia Treatment

open access: yesJournal of Current Ophthalmology
Purpose: To do a qualitative and quantitative assessment of the existing literature on the effectiveness and safety of pilocarpine 1.25% eye drops in presbyopia management. Methods: Relevant articles were extracted from the online database using keywords
Mamta Singh   +5 more
doaj   +1 more source

Strain differences in seizure-induced cell death following pilocarpine-induced status epilepticus

open access: yesNeurobiology of Disease, 2012
Mouse strains differ from one another in their susceptibility to seizure-induced excitotoxic cell death. Previously, we have demonstrated that mature inbred strains of mice show remarkable genetic differences in susceptibility to the neuropathological ...
P. Elyse Schauwecker
doaj   +1 more source

Cytotoxicity of pilocarpine to human corneal stromal cells and its underlying cytotoxic mechanisms [PDF]

open access: yesInternational Journal of Ophthalmology, 2016
AIM: To examine the cytotoxic effect of pilocarpine, an anti-glaucoma drug, on human corneal stromal (HCS) cells and its underlying cytotoxic mechanisms using an in vitro model of non-transfected HCS cells.
Xiao-Long Yuan   +3 more
doaj   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

open access: yesIbrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

Um novo modelo para o estudo de ansiedade: investigação das respostas emocionais em ratos tratados com pilocarpina [PDF]

open access: yes, 2013
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Farmacologia, Florianópolis, 2013.Objetivos: A influência de crises epilépticas nas respostas emocionais observadas em humanos e ...
Hoeller, Alexandre Ademar
core  

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

open access: yesNeuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi   +5 more
wiley   +1 more source

Segmental Pallor and Hair Loss in a Patient With Ross Syndrome: Case Report

open access: yesThe Journal of Dermatology, EarlyView.
ABSTRACT A 30‐year‐old male sought medical consultation due to sudden anisocoria. Clinical examination confirmed Adie's tonic pupil. Subsequently, the presence of segmental anhidrosis with compensatory hyperhidrosis and areflexia established the diagnosis of Ross syndrome.
Markus Augusto Martínez Holst   +5 more
wiley   +1 more source

Comparison of two fixed beta-blocker-pilocarpine combinations. The Carteolol-Pilocarpine Study Group

open access: yes, 1997
International audienceTo compare the efficacy and safety of a newly developed ophthalmic solution containing carteolol 2% and pilocarpine (2% (CBS341A) with a timolol 0.5% and pilocarpine 2% fixed combination.
C. J. M. Trinquand   +12 more
core   +1 more source

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