Results 41 to 50 of about 23,504 (181)

An algorithm for seizure detection in rodents

Epilepsia Open, EarlyView.
Abstract Objective Epilepsy animal research often relies on long‐term intracranial electroencephalographic (iEEG) recordings. Here, we describe an artificial neural network (ANN) algorithm for automatic detection of seizures. Methods The algorithm was trained on iEEG recordings of three mouse models of chronic epilepsy: (1) the pilocarpine model of ...
Lyna Kamintsky, Gerben van Hameren, Itai Weissberg, Pooyan Moradi, Ofer Prager, Alaa Abu Ahmad, Lior Schori, Albert Becker, Yaniv Zigel, Alon Friedman   +9 more
wiley   +1 more source

Artificial intelligence in preclinical epilepsy research: Current state, potential, and challenges

Epilepsia Open, EarlyView.
Abstract Preclinical translational epilepsy research uses animal models to better understand the mechanisms underlying epilepsy and its comorbidities, as well as to analyze and develop potential treatments that may mitigate this neurological disorder and its associated conditions. Artificial intelligence (AI) has emerged as a transformative tool across
Jesús Servando Medel‐Matus, Cesar Santana‐Gomez, Ruby G. Escalante, Dominique Duncan, Pedro F. Viana, Giulia Sofia Cereda, Naoto Kuroda, Aristea S. Galanopoulou   +7 more
wiley   +1 more source

Plasticity of GABAB receptor-mediated heterosynaptic interactions at mossy fibers after status epilepticus [PDF]

, 2003
Several neurotransmitters, including GABA acting at presynaptic GABAB receptors, modulate glutamate release at synapses between hippocampal mossy fibers and CA3 pyramidal neurons.
Bowery, N.G., Walker, M.C., Chandler, K.E., Chandler, K. E., Princivalle, A.P., Walker, M. C., Princivalle, A. P., Fabian-Fine, R., Bowery, N. G., Kullmann, D. M., Kullmann, D.M.   +10 more
core  

1% Pilocarpine Testing

, 2022
A brief description of using Pilocarpine to test the pupils in patients with ...
Karl C. Golnik, MD
core  

Molecular analysis of acute and chronic reactive astrocytes in the pilocarpine model of temporal lobe epilepsy

Neurobiology of Disease, 2016
Astroglia, the most abundant glial cells in the mammalian central nervous system (CNS), are considered an emerging key player in seizure induction and progression. Although astrocytes undergo reactive gliosis in temporal lobe epilepsy (TLE) with dramatic
Jerome Clasadonte, Lydie Morel, Camila M. Barrios-Camacho, Ming Sum R. Chiang, Jinhua Zhang, Lakshmanan Iyer, Philip G. Haydon, Yongjie Yang   +7 more
doaj   +1 more source

Status epilepticus: Updates on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley   +1 more source

Pilocarpine-induced morphological changes.

, 2015
A) Reconstruction of silicon probe placement within a coronal section of the hippocampus. Scaled silicon probe outlines were superimposed on sections counterstained with DAPI. DiI tracks and multiunit activity guided probe alignment. B) No differences in
Rod C. Scott (498608), Pierre-Pascal Lenck- Santini (765559), Sylvain Barrier (765558), Gregory L. Holmes (526852), Sean P. Flynn (765557)   +4 more
core   +1 more source

Primary argon laser trabeculoplasty vs pilocarpine 2% in open angle glaucoma : Two years follow-up study

Indian Journal of Ophthalmology, 1997
In a prospective study, the efficacy of argon laser trabeculoplasty (ALT) was evaluated and compared with pilocarpine 2% as primary treatment in newly diagnosed primary open angle glaucoma (POAG).
Sharma Ashok, Gupta Amod
doaj  

Neonatal seizures and GABAergic drugs: Scylla and Charybdis?

Epilepsia Open, EarlyView.
Abstract Neonates have a high incidence of seizures that are frequently difficult to control with conventional first‐line anti‐seizure medications, which are gamma‐aminobutyric acid (GABA) agonists. The reasons for this clinical problem are multifold but are likely related to the unique physiology of the immature nervous system. Specifically, the early
Kerry W. Thompson, Lucie Suchomelova, Claude G. Wasterlain   +2 more
wiley   +1 more source

Comparison of pilocarpine‐ versus exercise‐induced sweat sodium concentration across exercise intensities in trained athletes

Physiological Reports
Pilocarpine‐induced sweat testing offers a laboratory‐based method for assessing sweat composition, but its comparability to exercise sweating remains unclear.
Christopher T. Harris, Lindsey Hunt, Sam O. Shepherd, Tamara D. Hew‐Butler, Andrew V. Blow   +4 more
doaj   +1 more source