Results 21 to 30 of about 23,504 (181)

Pilocarpine-induced seizures associate with modifications of LSD1/CoREST/HDAC1/2 epigenetic complex and repressive chromatin in mice hippocampus

open access: yesBiochemistry and Biophysics Reports, 2021
Epilepsy is a neurological disorder of genetic or environmental origin characterized by recurrent spontaneous seizures. A rodent model of temporal lobe epilepsy is induced by a single administration of pilocarpine, a non-selective cholinergic muscarinic ...
Verónica Noches   +5 more
doaj   +1 more source

Pilocarpine-evoked membrane potential oscillations in RetCx MNs do not depend on voltage-gated sodium currents.

open access: yes, 2018
(A) Simultaneous intracellular recording of RetCx MN membrane potential and extracellular spike activity of the ipsilateral antagonistic retractor and protractor MN pools (RetCx MNs (nl5) and ProCx MNs (nl2)).
Joachim Schmidt (12665)   +3 more
core   +1 more source

Sub-Convulsing Dose Administration of Pilocarpine Reduces Glycemia, Increases Anxiety-Like Behavior and Decelerates Cortical Spreading Depression in Rats Suckled on Various Litter Sizes

open access: yesFrontiers in Neuroscience, 2018
Epilepsy and malnutrition constitute two worldwide health problems affecting behavior and brain function. The cholinergic agonist pilocarpine (300–380 mg/kg; single administration) reproduces the human type of temporal lobe epilepsy in rats.
Elian da Silva Francisco   +1 more
doaj   +1 more source

Pilocarpine-induced residual oxygen consumption in perfused submandibular glands of rats.

open access: yes, 2019
Submandibular glands were stimulated with 1–1000 μM pilocarpine or 0.2–1 μM carbachol (CCh) for 5 min. Profiles of oxygen consumption induced by pilocarpine or carbachol (a). Stimulating duration is indicated as black bars.
Takanori Narita (25602)   +3 more
core   +1 more source

Pilocarpine-induced [Ca2+]i elevations in RetCx MN neurites and extracellular recorded spike activity of RetCx MNs.

open access: yes, 2018
(A) [Ca2+]i was measured in five regions of interest. Dashed lines indicate the outline of the respective hemiganglion and nerve roots. na nervus anterior, nl1-nl5 nervi laterali 1 to 5, ncr nervus cruris, np nervus posterior, nup nervus unparis (see [22]
Joachim Schmidt (12665)   +3 more
core   +1 more source

The pilocarpine model of temporal lobe epilepsy [PDF]

open access: yes, 2008
Understanding the pathophysiogenesis of temporal lobe epilepsy (TLE) largely rests on the use of modelsof status epilepticus (SE), as in the case of the pilocarpine model.
Massimo Avoli   +11 more
core   +1 more source

The inhibitory effects of Npas4 on seizures in pilocarpine-induced epileptic rats.

open access: yesPLoS ONE, 2014
To explore the effects of neuronal Per-Arnt-Sim domain protein 4 (Npas4) on seizures in pilocarpine-induced epileptic rats, Npas4 expression was detected by double-label immunofluorescence, immunohistochemistry, and Western blotting in the brains of ...
Dan Wang   +8 more
doaj   +1 more source

Highly Enantioselective Syntheses of Functionalized α-Methylene-γ-butyrolactones via Rh(I)-catalyzed Intramolecular Alder Ene Reaction:  Application to Formal Synthesis of (+)-Pilocarpine

open access: yes, 2016
A highly enantioselective Rh(I)-catalyzed intramolecular Alder ene reaction has been developed. The desired products, 3-vinyl, vinyl acetate, and vinyl ether-substitued α-methylene-γ-butyrolactones were formed in high yields. Aldehydes were produced with
Xumu Zhang (1447558)   +2 more
core   +1 more source

The Effect of 1% Pilocarpine Mouthwash on Salivary Flow Rate in Patients with Radiation-Induced Xerostomia: A Double-Blind Randomized Clinical Trial [PDF]

open access: yesMiddle East Journal of Cancer
Background: Radiation-induced hyposalivation is a common complication of radiotherapy for head and neck cancers. The most commonly prescribed medication for hyposalivation is pilocarpine. However, due to the numerous systemic side-effects associated with
Paria Motahari   +5 more
doaj   +1 more source

Printed Wearable Sweat Rate Sensor for Continuous In Situ Perspiration Measurement

open access: yesAdvanced Intelligent Systems, Volume 7, Issue 3, March 2025.
A wireless wearable sweat rate sensor system is presented, featuring digital 3D direct‐write printing on a flexible substrate with microfluidic layers for continuous, real‐time monitoring. Printed encapsulated metal electrodes are used for capacitance measurements, achieving high sensitivity (0.01 μL min−1) while maintaining a compact and lightweight ...
Mohammad Shafiqul Islam   +6 more
wiley   +1 more source

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