Results 11 to 20 of about 23,504 (181)

Effect of pilocarpine mouthwash on salivary flow

open access: yesBrazilian Journal of Medical and Biological Research, 2002
Pilocarpine is a cholinergic agonist that increases salivary flow and has been used to treat xerostomia. Oral intake is the most frequent route of administration.
R. Bernardi   +7 more
doaj   +2 more sources

Does pilocarpine-induced epilepsy in adult rats require status epilepticus? [PDF]

open access: yesPLoS ONE, 2009
Pilocarpine-induced seizures in rats provide a widely animal model of temporal lobe epilepsy. Some evidences reported in the literature suggest that at least 1 h of status epilepticus (SE) is required to produce subsequent chronic phase, due to the SE ...
Graciela Navarro Mora   +7 more
doaj   +3 more sources

Aging and topical pilocarpine concentrations effects on pupil size and tear flow rate

open access: yesJournal of Optometry, 2010
Purpose: This is to evaluate the effects of age and different concentrations of pilocarpine on tear flow rate and pupil size. Methods: The tear flow rates and pupil sizes of eighty-one volunteers were measured with Schimer's strips and a meter rule gauge,
Michael O. Emina
doaj   +1 more source

Pilocarpine induces the residual secretion of salivary fluid in perfused submandibular glands of rats.

open access: yesPLoS ONE, 2019
Pilocarpine is an M3 muscarinic agonist that is widely used for the treatment of xerostomia caused by various diseases and medical conditions. Pilocarpine induced the secretion of salivary fluid in perfused submandibular glands of rats.
Takanori Narita   +3 more
doaj   +1 more source

Administration of pilocarpine by microneedle patch as a novel method for cystic fibrosis sweat testing

open access: yesBioengineering & Translational Medicine, 2021
The sweat test is the gold standard for the diagnosis of cystic fibrosis (CF). The test utilizes iontophoresis to administer pilocarpine to the skin to induce sweating for measurement of chloride concentration in sweat.
Song Li   +5 more
doaj   +1 more source

Excitatory synaptic transmission in hippocampal area CA1 is enhanced then reduced as chronic epilepsy progresses

open access: yesNeurobiology of Disease, 2021
This study examines changes in synaptic transmission with progression of the chronic epileptic state. Male Sprague-Dawley rats (P40–45) were injected with either saline or pilocarpine.
Benjamin Owen   +2 more
doaj   +1 more source

Unraveling the Biosynthesis of Pilocarpine in

open access: yesNatural Product Communications, 2015
Pilocarpine is found exclusively in species of Pilocarpus and the presence of other imidazole alkaloids has been reported in several species of the genus. Pilocarpine has several important pharmaceutical applications. Although several imidazole alkaloids
Alexandra Christine Helena Frankland Sawaya   +2 more
doaj   +1 more source

The effects of a varying doses of pilocarpine and lithium induced status epilepticus, and treatment with BPC-157

open access: yesLiječnički vjesnik, 2023
Peptadecapeptide BPC -157 has been reported to have a large spectrum of in vivo activities, from anti-ulcer to central action on the brain dopaminergic system, in addition to the aforementioned, BPC-157 might counteract standard convulsant induced ...
Helen Marie Chiddenton   +2 more
doaj   +1 more source

Antagonism of peripheral inflammation reduces the severity of status epilepticus

open access: yesNeurobiology of Disease, 2009
Status epilepticus (SE) is one of the most serious manifestations of epilepsy. Systemic inflammation and damage of blood-brain barrier (BBB) are etiologic cofactors in the pathogenesis of pilocarpine SE while acute osmotic disruption of the BBB is ...
Nicola Marchi   +10 more
doaj   +1 more source

Effect of eugenol on lithium-pilocarpine model of epilepsy: behavioral, histological, and molecular changes [PDF]

open access: yesIranian Journal of Basic Medical Sciences, 2017
Objective(s): Epilepsy establishment gives rise to biochemical and morphological changes in the hippocampus. Oxidative stress, morphological changes, and mossy fiber sprouting (MFS) in the hippocampus underpin the epilepsy establishment.
Sara Joushi, Mahmoud Elahdadi Salmani
doaj   +1 more source

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