Results 11 to 20 of about 34,054 (232)
Modulation of the Thrombin Pathway Restores LTP in a Pilocarpine Mice Model of Status Epilepticus
Frontiers in Cellular Neuroscience, 2022 BackgroundStatus epilepticus (SE) leads to memory impairment following a seizure, attributed to long-term potentiation (LTP) reduction. Thrombin, a coagulation factor that activates protease-activated receptor 1 (PAR1) is involved in cognitive impairment
Efrat Shavit-Stein +14 more
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Brazilian Journal of Medical and Biological Research, 2003 We investigated the effect of L-NAME, a nitric oxide (NO) inhibitor and sodium nitroprusside (SNP), an NO-donating agent, on pilocarpine-induced alterations in salivary flow, mean arterial blood pressure (MAP) and heart rate (HR) in rats.
Wilson A. Saad +7 more
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Structural determinants at the M2 muscarinic receptor modulate the RGS4-GIRK response to pilocarpine by impairment of the receptor voltage sensitivity. [PDF]
, 2017 Membrane potential controls the response of the M2 muscarinic receptor to its ligands. Membrane hyperpolarization increases response to the full agonist acetylcholine (ACh) while decreasing response to the partial agonist pilocarpine.
Chen, I-Shan +2 more
core +1 more source
Neuropeptide receptors as potential antiepileptic drug targets : focus on the ghrelin axis [PDF]
, 2014 Epilepsy is a very serious neurological disorder which is often underrepresented. Around 50 million individuals worldwide have active epilepsy with recurrent seizures and in spite of the medical advances over the years, 30% of these patients remain as ...
Portelli, Jeanelle
core +1 more source
Arquivos de Neuro-Psiquiatria, 2011 Pilocarpine-induced seizures can be mediated by increases in oxidative stress and by cerebral amino acid changes. The present research suggests that antioxidant compounds may afford some level of neuroprotection against the neurotoxicity of seizures in ...
P S Santos +5 more
doaj +1 more source
Neuroinflammatory targets and treatments for epilepsy validated in experimental models [PDF]
, 2017 A large body of evidence that has accumulated over the past decade strongly supports the role of inflammation in the pathophysiology of human epilepsy.
Aronica, Eleonora +17 more
core +5 more sources
Aging and topical pilocarpine concentrations effects on pupil size and tear flow rate
Journal of Optometry, 2010 Purpose: This is to evaluate the effects of age and different concentrations of pilocarpine on tear flow rate and pupil size. Methods: The tear flow rates and pupil sizes of eighty-one volunteers were measured with Schimer's strips and a meter rule gauge,
Michael O. Emina
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PLoS ONE, 2019 Pilocarpine is an M3 muscarinic agonist that is widely used for the treatment of xerostomia caused by various diseases and medical conditions. Pilocarpine induced the secretion of salivary fluid in perfused submandibular glands of rats.
Takanori Narita +3 more
doaj +1 more source
Neurobiology of Disease, 2021 This study examines changes in synaptic transmission with progression of the chronic epileptic state. Male Sprague-Dawley rats (P40–45) were injected with either saline or pilocarpine.
Benjamin Owen +2 more
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