Results 1 to 10 of about 189 (100)

Seasonal change in main alkaloids of jaborandi (Pilocarpus microphyllus Stapf ex Wardleworth), an economically important species from the Brazilian flora [PDF]

PLoS ONE, 2017
Pilocarpus microphyllus Stapf ex Wardleworth (jaborandi, Rutaceae) is one of the most important Brazilian medicinal species owing to its content of pilocarpine (PIL), an alkaloid used for treating glaucoma and xerostomia.
Isabel Mafra, Jefferson Almeida Rocha, JOSÉ Roberto Leite   +2 more
exaly   +6 more sources

HPLC-ESI-MS/MS of Imidazole Alkaloids in Pilocarpus microphyllus [PDF]

Molecules, 2008
Pilocarpine, an important imidazole alkaloid, is extracted from the leaves of Pilocarpus microphyllus (Rutaceae), known in Brazil as jaborandi and used mainly for the treatment of glaucoma.
Alexandra Christine Helena Frankland Sawaya, Paulo Mazzafera, Marcos Nogueira Eberlin   +2 more
exaly   +4 more sources

Epiisopiloturine, an Alkaloid from Pilocarpus microphyllus, Attenuates LPS-Induced Neuroinflammation by Interfering in the TLR4/NF-κB-MAPK Signaling Pathway in Microglial Cells. [PDF]

Oxid Med Cell Longev, 2023
Neuroinflammation is present in the pathophysiological mechanisms of several diseases that affect the central nervous system (CNS). Microglia have a prominent role in initiating and sustaining the inflammatory process. Epiisopiloturine (EPI) is an imidazole alkaloid obtained as a by‐product of pilocarpine extracted from Pilocarpus microphyllus ...
de Sousa JAC, Azul FVCS, de Araújo AB, Tomé RC, Silva FRM, de Vasconcelos SMM, Rios FJ, Leal LKAM.   +7 more
europepmc   +2 more sources

Potential Distribution of Pilocarpus microphyllus in the Amazonia/Cerrado Biomes under Near-Future Climate Change Scenarios [PDF]

Plants, 2023
Pilocarpus microphyllus Stapf. ex Wardlew. (Rutaceae) is an endemic and threatened medicinal plant species from tropical Brazil. Popularly known as “jaborandi”, it is the unique natural source of pilocarpine, an alkaloid used to medical treat glaucoma ...
Waléria P. Monteiro, Everaldo B. de Souza, Leonardo de Sousa Miranda, Luciano J. S. Anjos, Cecilio F. Caldeira   +4 more
doaj   +2 more sources

Exploring the Therapeutic Potential of Traditional Antimalarial and Antidengue Plants: A Mechanistic Perspective. [PDF]

Can J Infect Dis Med Microbiol, 2023
Malaria, a highly perilous infectious disease, impacted approximately 230 million individuals globally in 2019. Mosquitoes, vectors of over 10% of worldwide diseases, pose a significant public health menace. The pressing need for novel antimalarial drugs arises due to the imminent threat faced by nearly 40% of the global population and the escalating ...
Kamaraj C, Ragavendran C, Prem P, Naveen Kumar S, Ali A, Kazmi A, Ullah A, Chandra Satish Kumar R, Khan SU, Luna-Arias JP, Mashwani ZU, Balasubramani G, Rehman SU.   +12 more
europepmc   +2 more sources

Extrativismo, cultivo e privatização do jaborandi (Pilocarpus microphyllus Stapf ex Holm.; Rutaceae) no Maranhão, Brasil Extractivism, cultivation and privatization of jaborandi (Pilocarpus microphyllus Stapf ex Holm.; Rutaceae) in Maranhão, Brazil [PDF]

Acta Botânica Brasílica, 2002
Um dos processos associados com a expansão de fronteiras em países em desenvolvimento consiste na privatização de recursos naturais, anteriormente de uso comum por populações tradicionais.
Claudio Urbano B. Pinheiro
doaj   +4 more sources

Cytotoxic and Antileishmanial Potential of Pilocarpus microphyllus Essential Oil: In Vitro and In Silico Study. [PDF]

Chem Biodivers
Jaborandi (Pilocarpus microphyllus) essential oil is obtained by removal and characterization using GC‐MS, revealing γ‐cadinene and trans‐caryophyllene as major constituents. The oil exhibits biological activity, with antifungal action against Candida spp.
Silva JC, Mendes MGA, Sousa PSA, Nobre ARA, Alves MMM, Carvalho FAA, Daboit TC, Neto JSL, Pinheiro YVF, Sousa YDC, Sousa EDS, Filho JDBM, Araújo AJ, Filho FAS, de Lima SG, Véras LMC.   +15 more
europepmc   +2 more sources

Fenologia e prospecção fitoquímica do jaborandi (Pilocarpus microphyllus Stapf ex Holmes) [PDF]

Revista Brasileira de Plantas Medicinais, 2016
RESUMO O estudo fenológico tem como finalidade determinar o ritmo sazonal dos eventos do ciclo de vida da planta, como floração e frutificação. Estes eventos são determinados por uma série de fatores, como: alternância de períodos chuvosos ou não ...
C.S.A. OLIVEIRA, O.A. LAMEIRA, F.N.S. RIBEIRO, T.T. ROCHA, R.M.A. DE ASSIS   +4 more
doaj   +3 more sources

Decoding pilocarpine biosynthesis and its roles in Pilocarpus microphyllus through a comparative transcriptomics approach [PDF]

BMC Plant Biology
Background Pilocarpus microphyllus, widely known as jaborandi, faces a decline in its natural population due to unsustainable harvesting for pilocarpine extraction, an imidazole alkaloid with significant pharmacological properties.
Mariane Brom Sobreiro, Giordano Bruno Soares-Souza, Leandro Magalhães, Débora de Morais Cordeiro, Michele Molina, Santelmo Vasconcelos, Yan Nunes Dias, Renato R. Moreira-Oliveira, Markus Gastauer, Silvio Ramos, Guilherme Oliveira, Cecílio Frois Caldeira, Amanda F. Vidal   +12 more
doaj   +2 more sources

Industrial Scale Isolation, Structural and Spectroscopic Characterization of Epiisopiloturine from Pilocarpus microphyllus Stapf Leaves: A Promising Alkaloid against Schistosomiasis. [PDF]

PLoS ONE, 2013
This paper presents an industrial scale process for extraction, purification, and isolation of epiisopiloturine (EPI) (2(3H)-Furanone,dihydro-3-(hydroxyphenylmethyl)-4-[(1-methyl-1H-imidazol-4-yl)methyl]-, [3S-[3a(R*),4b]]), which is an alkaloid from ...
Leiz M C Véras, Vanessa R R Cunha, Filipe C D A Lima, Maria A Guimarães, Marianne M Vieira, Yuri D M Campelo, Vanessa Y Sakai, David F Lima, Paulo S Carvalho, Javier A Ellena, Paulo R P Silva, Luciene C Vasconcelos, Markus Godejohann, Helena M Petrilli, Vera R L Constantino, Yvonne P Mascarenhas, José Roberto de Souza de Almeida Leite   +16 more
doaj   +2 more sources