Cytotoxic and Antileishmanial Potential of Pilocarpus microphyllus Essential Oil: In Vitro and In Silico Study [PDF]
Chemistry and BiodiversityJaborandi (Pilocarpus microphyllus) essential oil is obtained by removal and characterization using GC‐MS, revealing γ‐cadinene and trans‐caryophyllene as major constituents. The oil exhibits biological activity, with antifungal action against Candida spp.
De Lima Sidney Gonçalo +2 more
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Potential Distribution of Pilocarpus microphyllus in the Amazonia/Cerrado Biomes under Near-Future Climate Change Scenarios [PDF]
Plants, 2023 Pilocarpus microphyllus Stapf. ex Wardlew. (Rutaceae) is an endemic and threatened medicinal plant species from tropical Brazil. Popularly known as “jaborandi”, it is the unique natural source of pilocarpine, an alkaloid used to medical treat glaucoma ...
Waléria P. Monteiro +4 more
doaj +5 more sources
HPLC-ESI-MS/MS of Imidazole Alkaloids in Pilocarpus microphyllus [PDF]
Molecules, 2008 Pilocarpine, an important imidazole alkaloid, is extracted from the leaves of Pilocarpus microphyllus (Rutaceae), known in Brazil as jaborandi and used mainly for the treatment of glaucoma.
Alexandra Christine Helena Frankland Sawaya +2 more
exaly +7 more sources
Decoding pilocarpine biosynthesis and its roles in Pilocarpus microphyllus through a comparative transcriptomics approach [PDF]
BMC Plant BiologyBackground Pilocarpus microphyllus, widely known as jaborandi, faces a decline in its natural population due to unsustainable harvesting for pilocarpine extraction, an imidazole alkaloid with significant pharmacological properties.
Mariane Brom Sobreiro +12 more
doaj +5 more sources
Computational quantum chemistry, molecular docking, and ADMET predictions of imidazole alkaloids of Pilocarpus microphyllus with schistosomicidal properties. [PDF]
PLoS ONE, 2018 Schistosomiasis affects million people and its control is widely dependent on a single drug, praziquantel. Computational chemistry has led to the development of new tools that predict molecular properties related to pharmacological potential.
Jefferson A Rocha +9 more
doaj +8 more sources
Brazilian Journal of Veterinary Parasitology, 2016 The aim of this study was to assess the activity of aqueous (AE) and ethanolic extracts (EE) and pilocarpine hydrochloride, which were extracted and isolated from Pilocarpus microphyllus (Jaborandi), respectively, on Rhipicephalus (Boophilus) microplus ...
Livio Martins Costa-Júnior +2 more
exaly +8 more sources
Epiisopiloturine, an Alkaloid from Pilocarpus microphyllus, Attenuates LPS-Induced Neuroinflammation by Interfering in the TLR4/NF-κB-MAPK Signaling Pathway in Microglial Cells. [PDF]
Oxid Med Cell Longev, 2023 Neuroinflammation is present in the pathophysiological mechanisms of several diseases that affect the central nervous system (CNS). Microglia have a prominent role in initiating and sustaining the inflammatory process. Epiisopiloturine (EPI) is an imidazole alkaloid obtained as a by‐product of pilocarpine extracted from Pilocarpus microphyllus ...
de Sousa JAC +7 more
europepmc +3 more sources
Unraveling the Biosynthesis of Pilocarpine in [PDF]
Natural Product Communications, 2015 Pilocarpine is found exclusively in species of Pilocarpus and the presence of other imidazole alkaloids has been reported in several species of the genus. Pilocarpine has several important pharmaceutical applications. Although several imidazole alkaloids
Alexandra Christine Helena Frankland Sawaya +2 more
doaj +4 more sources
Seasonal variation in the essential oil of Pilocarpus microphyllus Stapf. [PDF]
Anais Da Academia Brasileira De Ciencias, 2003 The essential oils of the leaves and fine stems of Pilocarpus microphyllus, collected on iron mineralized soil of the Serra de Carajás, Southeast of Pará State, Brazil, during the rainy and dry seasons, were obtained by hydrodistillation and analyzed by ...
FRANCISCA S. N. TAVEIRA +3 more
exaly +7 more sources
Herbal and Natural Treatments for the Management of the Glaucoma: An Update. [PDF]
Biomed Res Int, 2023 Glaucoma causes the degeneration of the retinal ganglion cells (RGCs) and their axons, inducing a tissue reshaping that affects both the retina and the optic nerve head. Glaucoma care especially focuses on reducing intraocular pressure, a significant risk factor for progressive damage to the optic nerve.
Vitiello L +5 more
europepmc +2 more sources