Results 91 to 100 of about 682 (124)

PZQ Therapy: How Close are we in the Development of Effective Alternative Anti-schistosomal Drugs? [PDF]

Infect Disord Drug Targets, 2019
Aruleba RT, Adekiya TA, Oyinloye BE, Masamba P, Mbatha LS, Pretorius A, Kappo AP.   +6 more
europepmc   +1 more source

Epiisopilosine alkaloid has activity against Schistosoma mansoni in mice without acute toxicity. [PDF]

PLoS One, 2018
Guimarães MA, de Oliveira RN, de Almeida RL, Mafud AC, Sarkis ALV, Ganassin R, da Silva MP, Roquini DB, Veras LM, Sawada TCH, Ropke CD, Muehlmann LA, Joanitti GA, Kuckelhaus SAS, Allegretti SM, Mascarenhas YP, de Moraes J, Leite JRSA, Leite JRSA.   +18 more
europepmc   +1 more source

Nephroprotective Plant Species Used in Brazilian Traditional Medicine for Renal Diseases: Ethnomedical, Pharmacological, and Chemical Insights. [PDF]

Plants (Basel)
Moraes Carlesso R, Cappellari YLR, Boeff DD, da Costa Pereira A, Schmitt Rusch E, de Souza Claudino T, Ritter MR, Konrath EL.   +7 more
europepmc   +1 more source

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Pilocarpus microphyllus seedling growth threatened by climate change: an ecophysiological approach

Theoretical and Applied Climatology, 2021
The climate change endangers many species of the Amazon Forest. An example, in the endangered medicinal species Pilocarpus microphyllus (popularly known as jaborandi). The jaborandi is a natural source of alkaloids used for serious diseases, essential for medical use.
Genilda Canuto Amaral, José Eduardo Macedo Pezzopane, Rogério de Souza Nóia Júnior, Manuel Fernández Martínez, Mariana Duarte Silva Fonseca, Elbya Leão Gibson, João Vitor Toledo, José Ricardo Macedo Pezzopane, Valéria Hollunder Klippel, Talita Miranda Teixeira Xavier   +9 more
openaire   +2 more sources

Production of pilocarpine in callus of jaborandi (pilocarpus microphyllus stapf)

In Vitro Cellular and Developmental Biology - Plant, 2005
Summary Jaborandi (Pilocarpus microphyllus) is the only known source of pilocarpine, and although this alkaloid is the only natural compound used to treat glaucoma, very little is known about its metabolism. Calluses obtained from petioles of P. microphyllus leaves were partially immersed in MS (Murashige and Skoog) liquid medium containing different ...
Paulo Mazzafera, Marcos Nogueira Eberlin, Eberlin Marcos Nogueira   +2 more
exaly   +2 more sources

Reference genes for quantitative RT-PCR of the pilocarpine producer Pilocarpus microphyllus and two other Pilocarpus species

Theoretical and Experimental Plant Physiology, 2017
Members of the genus Pilocarpus are the only natural source of the imidazole alkaloid pilocarpine, a plant metabolite widely used in the pharmaceutical industry. Although there is variation in the pilocarpine content in Pilocarpus, only the species Pilocarpus spicatus does not have pilocarpine, although it contains other imidazole alkaloids related ...
Mariana Crotti Franco, Flávia Camila Schimpl, Paulo Mazzafera   +2 more
semanticscholar   +3 more sources

Characterisation of the membrane transport of pilocarpine in cell suspension cultures of Pilocarpus microphyllus

Journal of Plant Physiology, 2015
Pilocarpine is an alkaloid obtained from the leaves of Pilocarpus genus, with important pharmaceutical applications. Previous reports have investigated the production of pilocarpine by Pilocarpus microphyllus cell cultures and tried to establish the alkaloid biosynthetic route.
Nathalia Luiza, Andreazza, Ilka Nacif, Abreu, Alexandra Christine Helena Frankland, Sawaya, Paulo, Mazzafera   +3 more
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Development and validation of a rapid RP-HPLC-DAD analysis method for the quantification of pilocarpine in Pilocarpus microphyllus (Rutaceae)

Food and Chemical Toxicology, 2018
A method using high performance liquid chromatography with diode array detector (HPLC-DAD) for identification and quantification of pilocarpine in the extract of Pilocarpus microphyllus, popularly known as jaborandi. The analysis was conducted using RP-18 column (250 mm × 4.6 mm x 5 μm id) and a buffer solution composed of acidified water, phosphoric ...
Rafael Caldas Pereira, Carla de Fátima Alves Nonato, Cicera Janaine Camilo, Henrique Douglas Melo Coutinho, Fabíola Fernandes Galvão Rodrigues, Jianbo Xiao, José Galberto Martins da Costa   +6 more
openaire   +3 more sources

CCXXXVII.—Pilosine: a new alkaloid from Pilocarpus microphyllus

Journal of the Chemical Society Transactions, 1912
Frank Lee Pyman
exaly   +2 more sources