The miR-139-5p regulates proliferation of supratentorial paediatric low-grade gliomas by targeting the PI3K/AKT/mTORC1 signalling [PDF]
, 2018 Paediatric low-grade gliomas (pLGGs) are a heterogeneous group of brain tumours associated with a high overall survival: however, they are prone to recur and supratentorial lesions are difficult to resect, being associated with high percentage of disease
Antonelli, Manila +19 more
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Frontiers in Pediatrics, 2021 Introduction: Arterial Spin Labeling (ASL), a perfusion assessment without using gadolinium-based contrast agents, is outstandingly advantageous for pediatric patients. The differentiation of medulloblastomas from pilocytic astrocytomas in children plays
Nguyen Minh Duc +2 more
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Pilocytic Astrocytoma Arising in Ovarian Mature Cystic Teratoma: An Unusual Neuroectodermal Malignant Transformation Occurring in Pregnant Female [PDF]
Journal of Clinical and Diagnostic Research, 2023 Mature cystic teratomas are usually benign, however malignant transformation occurs rarely. It is identified in only 0.17-2% of cases. Malignant cells can arise from cell of any type, but most common malignant transformation found to be squamous cell ...
Kalaivani Amitkumar +4 more
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Concurrent MEK targeted therapy prevents MAPK pathway reactivation during BRAFV600E targeted inhibition in a novel syngeneic murine glioma model. [PDF]
, 2016 Inhibitors of BRAFV600E kinase are currently under investigations in preclinical and clinical studies involving BRAFV600E glioma. Studies demonstrated clinical response to such individualized therapy in the majority of patients whereas in some patients ...
Berger, Mitchel S +12 more
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SAGE Open Medical Case Reports, 2018 Optic nerve pilocytic astrocytoma is an uncommon but well-known entity; however, intraorbital ancient pilocytic astrocytoma of the optic nerve is extremely rarely reported.
Haesu Lee Motoyama +4 more
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Molecular analysis of pediatric brain tumors identifies microRNAs in pilocytic astrocytomas that target the MAPK and NF-kappa B pathways [PDF]
, 2015 RT-qPCR confirms (a) up-regulation of miR-34a, miR-146a, miR-542-3p and miR-503 in pilocytic astrocytomas. (b) low expression of miR-124*, miR-129 and miR-129* in pilocytic astrocytomas.
A Freund +51 more
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Transcriptional profiles of pilocytic astrocytoma are related to their three different locations, but not to radiological tumor features [PDF]
, 2015 List of genes differentiating between pilocytic astrocytomas by different clinical features (DOCX 117 ...
Aleksandra Pfeifer +6 more
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Expression of P53 and Ki-67 in Different Grades of Astrocytomas [PDF]
International Journal of Medical Arts, 2022 Background: Astrocytomas are considered the most prevalent central nervous system [CNS] tumors. Diffuse astrocytomas are evaluated by a three-tiered system [II, III, and IV] according to the 2007 WHO classification. The WHO grading scheme is based on the
Rania Rifat Abdel-Maqsoud Mohamed +1 more
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Molecularly defined diffuse leptomeningeal glioneuronal tumor (DLGNT) comprises two subgroups with distinct clinical and genetic features [PDF]
, 2018 Diffuse leptomeningeal glioneuronal tumors (DLGNT) represent rare CNS neoplasms which have been included in the 2016 update of the WHO classification. The wide spectrum of histopathological and radiological features can make this enigmatic tumor entity ...
Brandner, Sebastian +34 more
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Free Neuropathology, 2023 Introduction: Pilocytic astrocytoma (PA) is one of the most common primary intracranial neoplasms in childhood with an overall favorable prognosis. Despite decades of experience, there are still diagnostic and treatment challenges and unresolved issues ...
Ibrahim Kulac +6 more
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