Results 61 to 70 of about 13,685 (188)

Genomic Profiling of Pediatric Solid Tumors With a Dual DNA/RNA Panel: JCCG‐TOP2 Study

Cancer Science, Volume 117, Issue 2, Page 522-535, February 2026.
In the JCCG‐TOP2 nationwide pediatric cancer genomic profiling study, 204 patients' tumors and peripheral blood from 50 institutions across Japan were successfully analyzed using a dual DNA/RNA panel. A total of 147 (72%) had potentially actionable findings, including diagnostic, prognostic, and therapeutic findings in 111 (54%), 61 (30%), and 64 (31%),
Kayoko Tao, Takako Yoshioka, Miho Kato, Kazuyuki Komatsu, Shinichi Tsujimoto, Kenichi Sakamoto, Kazuki Tanimura, Minako Sugiyama, Masahiro Sekiguchi, Yoshiko Nakano, Yoshihiro Otani, Yasushi Yatabe, Akihiko Yoshida, Hajime Okita, Junko Hirato, Kenichi Kohashi, Yukichi Tanaka, Shinji Kohsaka, Takashi Kubo, Kuniko Sunami, Makoto Hirata, Shuichi Tsutsumi, Hiroyuki Aburatani, Katsuyoshi Koh, Masahiro Hirayama, Shuhei Karakawa, Yukayo Terashita, Hiroyuki Fujisaki, Takeshi Yagi, Akihiro Yoneda, Shinji Mochizuki, Hiroyuki Shichino, Tatsuya Suzuki, Tetsuya Takimoto, Koichi Ichimura, Chitose Ogawa, Kimikazu Matsumoto, Hitoshi Ichikawa, Motohiro Kato   +38 more
wiley   +1 more source

Multi‐Omics Integration for Advancing Glioma Precision Medicine

Annals of Clinical and Translational Neurology, Volume 13, Issue 1, Page 4-13, January 2026.
ABSTRACT Gliomas are among the most malignant and aggressive tumors of the central nervous system, characterized by the absence of early diagnostic markers, poor prognosis, and a lack of effective treatments. Advances in high‐throughput technologies have facilitated a refined molecular classification of gliomas, incorporating genetic features. However,
Maria Guarnaccia, Valentina La Cognata, Giulia Gentile, Giovanna Morello, Sebastiano Cavallaro   +4 more
wiley   +1 more source

Unveiling the Uncommon: Primary Extra-axial Pilocytic Astrocytoma of the Cerebellopontine Angle

Medical Journal of Dr. D.Y. Patil Vidyapeeth
Glial tumors in the cerebellopontine angle (CPA) are uncommon and comprise less than 1% of CPA tumors. Primary extra-axial pilocytic astrocytoma of the CPA is very rare, with only four cases reported to date.
Madhuri Singh, Akshi Raj, Charusheela R. Gore, Shirish S. Chandanwale, Shirin Chandanwale   +4 more
doaj   +1 more source

A study of histopathological spectrum and expression of Ki-67, TP53 in primary brain tumors of pediatric age group

Indian Journal of Medical and Paediatric Oncology, 2012
Objectives: The primary brain tumors are the second most common cause of death due to malignancies in children. This study was done to analyze the histological spectrum of primary brain tumors in children and also to find out the expression of p53 and ...
Subhalakshmi Sengupta, Uttara Chatterjee, Uma Banerjee, Samarendranath Ghosh, Sandip Chatterjee, Ashit k Ghosh   +5 more
doaj   +1 more source

Pediatric brain tumor classification using digital pathology and deep learning: Evaluation of SOTA methods on a multi‐center Swedish cohort

Brain Pathology, Volume 36, Issue 1, January 2026.
Deep learning‐based feature extractors pretrained on histopathology images can classify pediatric brain tumors when applied to a multi‐center Swedish dataset. Abstract Brain tumors are the most common solid tumors in children and young adults, but the scarcity of large histopathology datasets has limited the application of computational pathology in ...
Iulian Emil Tampu, Per Nyman, Christoforos Spyretos, Ida Blystad, Alia Shamikh, Gabriela Prochazka, Teresita Díaz de Ståhl, Johanna Sandgren, Peter Lundberg, Neda Haj‐Hosseini   +9 more
wiley   +1 more source

Approaches Toward Improving the Prognosis of Pediatric Patients With Glioma: Pursuing Mutant Drug Targets With Emerging Small Molecules [PDF]

, 2014
Gliomas represent approximately 70% of all pediatric brain tumors and most of these are of astrocytic lineage, furthermore, malignant or high-grade astrocytoma account for approximately 20% of pediatric astrocytoma. Treatment options for pediatric glioma
Snape, Timothy J., Warr, Tracy
core   +1 more source

MRPS16 Regulates NFATC2 Through the Wnt/β‐Catenin Pathway to Promote Glioma Proliferation

Journal of Cellular and Molecular Medicine, Volume 30, Issue 2, January 2026.
ABSTRACT There have been reports that overexpression of mitochondrial ribosomal protein S16 (MRPS16) can greatly improve the growth of tumour cells, migration and invasion abilities in many ways. However, the role of MRPS16 in glioma cell proliferation, which is closely associated with tumour malignancy, remains unclear.
Xudong Li, Shaojie Yu, Minjie Wang, Zihan Gong, Qihong Cheng, Xuan Wang, Xiaobing Jiang   +6 more
wiley   +1 more source

Pilocytic astrocytoma masquerading as cerebeller abscess in a case of VSD with eisenmenger's syndrome : A rare case report

Journal of Marine Medical Society, 2015
Congenital cyanotic heart disease patients have increased risk of brain abscess via haematogenous spread. We report the case of a middle aged Lady with Eisenmenger's complex suspected of having a cerebellar abscess clinically and radiologically.
K I Mathai, V Vibhakar, Ananthkrishnan, Kushal Bhatia   +3 more
doaj   +1 more source

Molecular hallmarks of gliomas [PDF]

, 2011
Gliomas are a heterogeneous group of neoplasias that account for the majority of primary tumors of the central nervous system, of which glioblastoma multiforme is by far the most common and malignant subtype.
Costa, Bruno Marques, Pojo, Marta
core   +2 more sources

Feasibility and safety of awake craniotomy in adult patients with drug‐resistant focal epilepsy

Epilepsia, Volume 66, Issue 12, Page 4680-4697, December 2025.
Abstract Objective Although awake craniotomy can guide functional brain mapping and resection, its feasibility and safety have been poorly studied in large series of patients with drug‐resistant focal epilepsy surgery. Methods We conducted an observational, retrospective, single‐center cohort study of 588 consecutive awake craniotomies (2010–2024 ...
Marc Zanello, Gonzague De France, Angela Elia, Marco Demasi, Cristina Filipescu, Elisabeth Landre, Alessandro Moiraghi, Bénédicte Trancart, Maimiti Seneca, Agathe Guibert, Fabrice Chretien, Alexandre Roux, Johan Pallud   +12 more
wiley   +1 more source