Results 101 to 110 of about 572,234 (311)

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Evaluation of BT Telecare Pilot Project [PDF]

, 2010
Telecare can be defined as a mechanism for providing health and social services 'at a distance' - usually into the user's home - through the use of information and communication technologies.
Crump, N
core  

Musculoskeletal impairment survey in Rwanda: design of survey tool, survey methodology, and results of the pilot study (a cross sectional survey). [PDF]

, 2007
BACKGROUND: Musculoskeletal impairment (MSI) is an important cause of morbidity and mortality worldwide, especially in developing countries. Prevalence studies for MSI in the developing world have used varying methodologies and are seldom directly ...
Rischewski, D, Simms, V, Lavy, C, Rischewski Dorothea, Victoria Simms, Christopher Lavy, Kuper Hannah, Lavy Christopher, Simms Victoria, Atijosan Oluwarantimi, Dorothea Rischewski, Kuper, Hannah, Lavy, Christopher, Kuper, H, Hannah Kuper, Atijosan, O, Rischewski, Dorothea, Atijosan, Oluwarantimi, Simms, Victoria, Oluwarantimi Atijosan   +19 more
core   +1 more source

[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich, Jonathan A. Gernert, Hanna Zimmermann, Lisa Tagnin, Marianthi Zeinaki, Laura Sanzo, Letizia Vogler, Elisabeth Kaufmann, Justina Dargvainiene, Frank Leypoldt, Gérard N. Bischof, Robert Perneczky, Boris‐Stephan Rauchmann, Simon Lindner, Günter U. Höglinger, Rudolf A. Werner, Martin Kerschensteiner, Tania Kümpfel, Matthias Brendel, Franziska S. Thaler   +19 more
wiley   +1 more source

Driving automation: Learning from aviation about design philosophies

, 1977
Full vehicle automation is predicted to be on British roads by 2030 (Walker et al., 2001). However, experience in aviation gives us some cause for concern for the 'drive-by-wire' car (Stanton and Marsden, 1996). Two different philosophies have emerged in
Harris, Don, Harris, D, Young, Mark S., Stanton, Neville A., Stanton, NA, Young, MS   +5 more
core   +1 more source

Apply the We! Design methodology in E-learning 2.0 system design : a pilot study [PDF]

, 2012
During the emergence of Web 2.0, the methodologies and technologies of E-learning have developed to a new era, E-learning 2.0, emphasises on social learning and the use of social interaction tools. The students are the main end-user of the E-learning 2.0
Al Qudah, Dana, Shi, Lei, Cristea, Alexandra I.   +2 more
core   +1 more source

Comprehensive analysis of thickness-dependent structural, morphological, and optical properties of TiO2 based thin films

Results in Optics
In this study, three TiO2-based thin film samples were fabricated, and their thickness-dependent optical properties and crystal structures were systematically investigated.
B.D. Igamov, I.R. Bekpulatov, A.M. Normamatov, A.I. Kamardin, F.Sh. Kodirova, Gunel Imanova   +5 more
doaj   +1 more source

Comparing the Effect of Semi‐Immersive Virtual Reality, Computerized Cognitive Training, and Traditional Rehabilitation on Cognitive Function in Multiple Sclerosis: A Randomized Clinical Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio, Desiree Latella, Lilla Bonanno, Paulo Cezar Rocha dos Santos, Marcos Maldonado‐Díaz, Meir Plotnik, Rosaria De Luca, Angelo Quartarone, Rocco Salvatore Calabrò   +8 more
wiley   +1 more source

Pilot design and optimization in uplink cell-free integrated sensing and communication systems

Dianxin kexue
In response to the dual role of pilot signals in channel estimation and target localization, a pilot structure design and optimization method was proposed for the uplink cell-free integrated sensing and communication (CF-ISAC) system.
Tian Zhuoyan, Wang Jie, Li Jiamin, Zhu Pengcheng, Wang Dongming   +4 more
doaj  

Correlation between thickness-dependent morphology, phase structure, and vibrational properties of TiO2 thin films deposited via DC magnetron sputtering: A multi-technique characterization approach

Next Materials
In this study, the physicochemical properties of TiO₂ thin films with varying thicknesses (72 nm, 125 nm, and 283 nm) were systematically investigated using Raman and infrared (IR) spectroscopy.
B.D. Igamov, I.R. Bekpulatov, A.M. Normamatov, Gunel Imanova, A.I. Kamardin   +4 more
doaj   +1 more source