Results 61 to 70 of about 56,683 (321)

Coli Surface Antigen 26 Acts as an Adherence Determinant of Enterotoxigenic Escherichia coli and Is Cross-Recognized by Anti-CS20 Antibodies

Frontiers in Microbiology, 2018
The coli surface antigen 26 (CS26) of enterotoxigenic Escherichia coli (ETEC) had been described as a putative adhesive pilus based on the partial sequence of the crsH gene, detected in isolates from children with diarrhea in Egypt.
Leandro Cádiz, Alexia Torres, Raúl Valdés, Raúl Valdés, Gabriel Vera, Gabriel Vera, Daniela Gutiérrez, Myron M. Levine, David A. Montero, Miguel O’Ryan, Miguel O’Ryan, David A. Rasko, O. Colin Stine, Roberto Vidal, Roberto Vidal, Felipe Del Canto   +15 more
doaj   +1 more source

The Dynamic Structures of the Type IV Pilus

Microbiology spectrum, 2019
Type IV pilus (T4P)-like systems have been identified in almost every major phylum of prokaryotic life. They include the type IVa pilus (T4aP), type II secretion system (T2SS), type IVb pilus (T4bP), Tad/Flp pilus, Com pilus, and archaeal flagellum ...
M. McCallum, Lori L Burrows, P. L. Howell   +2 more
semanticscholar   +1 more source

A distinct sortase SrtB anchors and processes a streptococcal adhesin AbpA with a novel structural property. [PDF]

, 2016
Surface display of proteins by sortases in Gram-positive bacteria is crucial for bacterial fitness and virulence. We found a unique gene locus encoding an amylase-binding adhesin AbpA and a sortase B in oral streptococci.
Haase, EM, Liang, X, Liu, B, Matthews, S, Scannapieco, FA, Wu, H, Zhu, F   +6 more
core   +1 more source

A droplet digital PCR assay to measure pilin antigenic variation frequency in Neisseria gonorrhoeae

mSphere
The strict human pathogen Neisseria gonorrhoeae (gonococcus [Gc]) infects an estimated 82 million individuals globally and is a World Health Organization-designated bacterial pathogen of public health importance due to escalating antimicrobial resistance.
Sarah J. Quillin, Di Luo, Aoife Gavagan, Arthur Prindle, H Steven Seifert   +4 more
doaj   +1 more source

Evolutionary fine-tuning of conformational ensembles in FimH during host-pathogen interactions [PDF]

, 2017
Positive selection in the two-domain type 1 pilus adhesin FimH enhances Escherichia coli fitness in urinary tract infection (UTI). We report a comprehensive atomic-level view of FimH in two-state conformational ensembles in solution, composed of one low ...
Dodson, Karen W, Gross, Michael L, Hannan, Thomas J, Hibbing, Michael E, Holehouse, Alex S, Hultgren, Scott J, Janetka, James, Kalas, Vasilios, Pappu, Rohit V, Pinkner, Jerome S, Tolia, Niraj H, Zhang, Hao   +11 more
core   +3 more sources

Diversity and Evolution of Myxobacterial Type IV Pilus Systems

Frontiers in Microbiology, 2018
Type IV pili (T4P) are surface-exposed protein fibers that play key roles in the bacterial life cycle via surface attachment/adhesion, biofilm formation, motility, and development.
Gaurav Sharma, Lori L. Burrows, Mitchell Singer   +2 more
doaj   +1 more source

Functional plasticity in the type IV secretion system of Helicobacter pylori. [PDF]

, 2012
Helicobacter pylori causes clinical disease primarily in those individuals infected with a strain that carries the cytotoxin associated gene pathogenicity island (cagPAI).
Barrozo, Roberto M, Cariaga, Taryn A, Cooke, Cara L, Cover, Timothy L, Gaddy, Jennifer A, Hansen, Lori M, Johnson, Elizabeth M, Lam, Anna M, Peek, Richard M, Solnick, Jay V, Suarez, Giovanni   +10 more
core   +1 more source

Stochastic chain termination in bacterial pilus assembly

Nature Communications, 2023
Adhesive type 1 pili from uropathogenic Escherichia coli strains are filamentous, supramolecular protein complexes consisting of a short tip fibrillum and a long, helical rod formed by up to several thousand copies of the major pilus subunit FimA.
Christoph Giese, Chasper Puorger, Oleksandr Ignatov, Zuzana Bečárová, Marco E. Weber, Martin A. Schärer, Guido Capitani, Rudi Glockshuber   +7 more
doaj   +1 more source

Donor-strand exchange in chaperone-assisted pilus assembly revealed in atomic detail by molecular dynamics [PDF]

, 2008
Adhesive multi-subunit fibres are assembled on the surface of many pathogenic bacteria via the chaperone-usher pathway. In the periplasm, a chaperone donates a β-strand to a pilus subunit to complement its incomplete immunoglobulin-like fold.
Ashcroft, A.E., Paci, E., Radford, S.E., Rose, R.J., Waksman, G., Welsh, T.S.   +5 more
core   +1 more source

Molecular basis for sortase-catalyzed pilus tip assembly

mBio
During pilus assembly within the Gram-positive bacterial envelope, membrane-bound sortase enzymes sequentially crosslink specific pilus protein monomers through their cell wall sorting signals (CWSS), starting with a designated tip pilin, followed by the
Aadil H. Bhat, Chungyu Chang, Asis Das, Hung Ton-That   +3 more
doaj   +1 more source