Results 181 to 190 of about 19,713 (201)
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Pin1: A New Outlook in Alzheimers Disease
Current Alzheimer Research, 2011Neurodegenerative diseases termed Tauopathies, including Alzheimer disease, are characterized by the presence of intraneuronal neurofibrillary tangles (NFTs), composed by hyperphosphorylated protein Tau. Peptidyl-prolyl cis/trans isomerase Pin1 plays a pivotal role in the regulation of Tau phosphorylation/dephosphorylation state.
LONATI, ELENA RITA +2 more
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REVIEW: Pin1 in Alzheimer's disease
Journal of Neurochemistry, 2006AbstractProteolytic processing and phosphorylation of amyloid precursor protein (APP), and hyperphosphorylation of tau protein, have been shown to be increased in Alzheimer's disease (AD) brains, leading to increased production of β‐amyloid (Aβ) peptides and neurofibrillary tangles, respectively.
D. Allan Butterfield +6 more
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Substrate-Based Design of Reversible Pin1 Inhibitors
Biochemistry, 2002Human Pin1, a peptidyl-prolyl cis/trans isomerase with high specificity to -Ser/Thr(PO(3)H(2))-Pro- motifs, is required for cell cycle progression. In an effort to design reversible Pin1 inhibitors by using a substrate structure based approach, a panel of peptides were applied to systematically analyze the minimal structural requirements for Pin1 ...
Yixin, Zhang +4 more
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Stereospecific NANOG PEST Stabilization by Pin1
BiochemistryNANOG protein levels correlate with stem cell pluripotency. NANOG concentrations fluctuate constantly with low NANOG levels leading to spontaneous cell differentiation. Previous literature implicated Pin1, a phosphorylation-dependent prolyl isomerase, as a key player in NANOG stabilization.
Josephine C. Ferreon +8 more
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PtdIns5P and Pin1 in oxidative stress signaling
Advances in Biological Regulation, 2013Oxidative signaling is important in cellular health, involved in aging and contributes to the development of several diseases such as cancer, neurodegeneration and diabetes. Correct management of reactive oxygen species (ROS) prevents oxidative stress within cells and is imperative for cellular wellbeing.
Keune, Willem Jan +2 more
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Pin1 inhibitors: Pitfalls, progress and cellular pharmacology
Bioorganic & Medicinal Chemistry Letters, 2013Compelling data supports the hypothesis that Pin1 inhibitors will be useful for the therapy of cancer: Pin1 deficient mice resist the induction of breast cancers normally evoked by expression of MMTV-driven Ras or Erb2 alleles. While Pin1 poses challenges for drug discovery, several groups have identified potent antagonists by structure based drug ...
Jonathan D, Moore, Andrew, Potter
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Journal of neurochemistry, 2006
Proteolytic processing and phosphorylation of amyloid precursor protein (APP), and hyperphosphorylation of tau protein, have been shown to be increased in Alzheimer's disease (AD) brains, leading to increased production of beta-amyloid (Abeta) peptides and neurofibrillary tangles, respectively. These observations suggest that phosphorylation events are
D Allan, Butterfield +6 more
openaire +1 more source
Proteolytic processing and phosphorylation of amyloid precursor protein (APP), and hyperphosphorylation of tau protein, have been shown to be increased in Alzheimer's disease (AD) brains, leading to increased production of beta-amyloid (Abeta) peptides and neurofibrillary tangles, respectively. These observations suggest that phosphorylation events are
D Allan, Butterfield +6 more
openaire +1 more source
The peptidyl-prolyl isomerase Pin1.
Progress in cell cycle research, 2003The phospho-Ser/Thr-Pro specific prolyl-isomerase Pin1 has been implicated in multiple aspects of cell cycle regulation. It has been suggested that Pin1 function is required for both normal mitotic progression and reentry into the cell cycle from quiescence.
James D, Joseph +4 more
openaire +1 more source